36 Results for "

latent TGF

" in MedChemExpress (MCE) Product Catalog:
Products (36)

36 Results for "latent TGF" in MCE Product Catalog:

18
18 Publications Verification
Cat. No.: HY-P0299
CAS No.: 283609-79-0
Target:  

TGF-β Receptor

Research Areas:  

Cancer

LSKL, Inhibitor of Thrombospondin (TSP-1) is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) can readily crosse the blood-brain barrier .
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18
18 Publications Verification
Cat. No.: HY-P0299A
CAS No.: 2828433-17-4
Target:  

TGF-β Receptor

Research Areas:  

Cancer

LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier .
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3
3 Cited Publications
Cat. No.: HY-P78360
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;
Species:  
Mouse
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P73615
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;
Species:  
Rat
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P78214
Purity:  ≥ 90%, as determined by Bis-Tris PAGE.
Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P990667
CAS No.: 1439902-67-6
Synonyms: BG00011

Target:  

Integrin TGF-beta/Smad

Research Areas:  

Inflammation/Immunology Cancer

STX-100 (BG00011) is a humanized monoclonal antibody targeting αVβ6 integrin. STX-100 specifically binds αVβ6 integrin, blocks latent TGF-β activation via latency-associated peptide (LAP) interaction prevention, and reduces profibrotic responses. STX-100 can be used for the research of idiopathic pulmonary fibrosis, and cancer .
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Cat. No.: HY-P990069
CAS No.: 2640981-30-0
Synonyms: SRK-181

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Linavonkibart (SRK 181) is a high-affinity, fully human antibody that selectively binds to latent TGFβ1 and inhibits its activation. Linavonkibart plays an important role in cancer .
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Cat. No.: HY-P3971
CAS No.: 162559-45-7
Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on TGF-β1 activation. H-Leu-Ser-Lys-Leu-OH, binding with KRFK (HY-P3970), can block the signal transduction of TGF-β1, and prevent the progression of hepatic damage and fibrosis .
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Cat. No.: HY-182611
CAS No.: 1637468-93-9
Target:  

TGF-β Receptor

Research Areas:  

Inflammation/Immunology Cancer

SRI-31277 is a thrombospondin 1 (TSP-1) inhibitor with a human target pIC50 of 8.28 nM and in vivo activity, and exhibits a very short plasma half-life with intravenous administration.SRI-31277 inhibits interaction between TSP-1 and the latency-associated peptide (LAP) of latent TGF-β, blocking TSP-1-mediated TGF-β activation.SRI-31277 can be used for the research of multiple myeloma and fibrotic conditions .
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Cat. No.: HY-181430
CAS No.: 798546-78-8
Target:  

TGF-beta/Smad

PXS 25 is a cation-independent mannose 6-phosphate receptor (CI-M6PR) inhibitor that inhibits CI-M6PR-mediated activation of latent TGF-β1. PXS 25 inhibits conversion of high glucose-induced latent TGF-β1 to active TGF-β1 in proximal tubule cells under normoxic conditions. PXS 25 suppresses high glucose-induced fibronectin, collagen IV production, and phosphorylated Smad 2 in proximal tubule cells under normoxic conditions. PXS 25 has antifibrotic properties in skin fibroblasts. PXS 25 can be used for the research of diabetic nephropathy .
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Cat. No.: HY-P79307
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LTBP4; LTBP-4L; latent Transforming Growth Factor Beta Binding Protein 4; latent Transforming Growth Factor-Beta Binding Protein 4L; LTBP-4; ARCL1C; latent-Transforming Growth Factor Beta-Binding Protein 4; LTBP4L; FLJ46318; LTBP4S; FLJ90018
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700890
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFB3; Transforming Growth Factor, Beta 3; Prev. ARVD1; Transforming Growth Factor Beta; Prev. ARVD; TGF-Beta3; Transforming Growth Factor Beta-3 Proprotein; LDS5; Prepro-Transforming Growth Factor Beta-3; RNHF; Arrhythmogenic Right Ventricular Dysplasia
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P78802
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFB3; Transforming Growth Factor, Beta 3; Prev. ARVD1; Transforming Growth Factor Beta; Prev. ARVD; TGF-Beta3; Transforming Growth Factor Beta-3 Proprotein; LDS5; Prepro-Transforming Growth Factor Beta-3; RNHF; Arrhythmogenic Right Ventricular Dysplasia
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P701080
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFB3; Transforming Growth Factor, Beta 3; Prev. ARVD1; Transforming Growth Factor Beta; Prev. ARVD; TGF-Beta3; Transforming Growth Factor Beta-3 Proprotein; LDS5; Prepro-Transforming Growth Factor Beta-3; RNHF; Arrhythmogenic Right Ventricular Dysplasia
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-181431
CAS No.: 1253691-50-7
Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

PXS 64, a mannose-6-phosphate (M6P) analogue. a lipophilic prodrug of PXS 25 (HY-181430). PXS 64 is an effective anti-fibrotic agent by inhibiting the activation of latent TGF-β1. PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts. PXS 64 reduces TGFβ-mediated collagen IV, fibronectin, MCP-1, and phospho-smad2 expression in kidney cells. PXS 64 reduces collagen deposition in dermal scar fibroblasts. PXS 64 can be used for the research of chronic kidney disease, idiopathic pulmonary fibrosis, scarring .
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Cat. No.: HY-P73426
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P703860
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P70236
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P78584
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P705099
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated Peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;
Species:  
Human
Source:  
HEK293
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