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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
leucine activation
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "leucine activation" in MCE Product Catalog:
19
Target:
9
Target:
Research Areas:
Mefluleucine (NV-5138), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine is used for antidepressant studies .
9
9 Cited Publications
Synonyms: NV-5138 hydrochloride
Target:
Research Areas:
Mefluleucine (NV-513) hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine hydrochloride is used for antidepressant studies .
5
5 Cited Publications
Cat. No.: HY-N0486S9
CAS No.: 87828-86-2
1
1 Cited Publications
Cat. No.: HY-N0486S1
CAS No.: 74292-94-7
1
1
1 Cited Publications
Cat. No.: HY-N0486S
CAS No.: 106972-44-5
1
1 Cited Publications
Cat. No.: HY-N0486S8
CAS No.: 202406-52-8
Target:
Synonyms: KT7515
Research Areas:
CEP-1347 is an inhibitor of the JNK/SAPK pathway with neuroprotective effects. CEP-1347 blocks JNK1 activation induced by members of the mixed lineage kinase (MLK) family (MLK3, MLK2, MLK1, dual leucine zipper kinase, and leucine zipper kinase). As an inhibitor of MDM4, CEP-1347 can more effectively inhibit the growth of glioma cells expressing wild-type p53 .
Cat. No.: HY-N0486S2
CAS No.: 201740-84-3
Cat. No.: HY-N0486S6
CAS No.: 285977-88-0
Target:
Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria .
Cat. No.: HY-176806
CAS No.: 606967-53-7
Synonyms: Doxorubicin-LNAA-Boc
Target:
Research Areas:
Legubicin (Doxorubicin-LNAA-Boc) is a novel conjugate of Doxorubicin (HY-15142A) and a Legumain-cleavable peptide linker. Legubicin is activated by Legumain to release leucine-doxorubicin while sparing normal tissues. Legubicin inhibits tumor cell growth and reduces DNA binding in non-legumain expressing cells. Legubicin completely arrests tumor growth in mice bearing CT26 tumors. Legubicin can be used for the study of colon carcinoma (CRC) .
Cat. No.: HY-W015876
CAS No.: 7533-40-6
Synonyms: (+)-Leucinol
Target:
Research Areas:
L-Leucinol ((+)-Leucinol) is a competitive aminopeptidase inhibitor with a Ki value of 17 μM. As a dietary intake inhibitor, L-Leucinol reduces the basal dietary leucine intake in rats via microinjection into the rat anterior piriform cortex .
Cat. No.: HY-N0486S4
CAS No.: 92751-17-2
Cat. No.: HY-N0486S3
CAS No.: 59935-31-8
Synonyms: N-FMOC-leucine-d3; NPC 15199-d3; NSC 334290-d3
Cat. No.: HY-101064S1
CAS No.: 1163133-36-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
