2095886-80-7
2095886-80-7
Chemical Structure
Mefluleucine
Synonym(s): NV-5138
- CAS No.: 2095886-80-7
- Formula:C7H13F2NO2
- Molecular Weight:181.18
IUPAC Name: (S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid
InChIKey: HRFIMCJTDKEPPV-BYPYZUCNSA-N
SMILES: N[C@@H](CC(C)(C(F)F)C)C(O)=O
Biological Activity: Mefluleucine (NV-5138), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine is used for antidepressant studies[1][2].
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Mefluleucine | 98.0% | Mefluleucine (NV-5138), a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. Mefluleucine is used for antidepressant studies. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-114384BMefluleucine hydrochloride -
Similarity Score 0.80
HY-794154-Methyl-L-leucine -
Similarity Score 0.77
HY-W0375495,5,5-Trifluoro-DL-leucine -
Similarity Score 0.77
HY-W0749783-Fluoro-DL-valine -
Similarity Score 0.76
HY-W0192632-Amino-4,4,4-trifluorobutyric acid -
Similarity Score 0.76
HY-W078733(S)-2-Amino-4,4,4-trifluorobutanoic acid -
Similarity Score 0.75
HY-N0486S2L-Leucine-13C6 -
Similarity Score 0.75
HY-N0486S5L-Leucine-2-13C -
Similarity Score 0.75
HY-N0486S6L-Leucine-2-13C,15N -
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References
- [1]. Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107. [Content Brief]
- [2]. Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. [Content Brief]
