223 Results for "

lipid synthesis

" in MedChemExpress (MCE) Product Catalog:
Products (223)

223 Results for "lipid synthesis" in MCE Product Catalog:

21
21 Publications Verification
Cat. No.: HY-108496
CAS No.: 26993-30-6
Purity:  ≥99.0%
Synonyms: S1P
Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca 2+ as an extracellular ligand for G protein-coupled receptors . Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids . Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration .
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12
12 Cited Publications
Cat. No.: HY-B1125
CAS No.: 3416-24-8
Synonyms: D-Glucosamine; Chitosamine
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
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12
12 Cited Publications
Cat. No.: HY-N0733
CAS No.: 66-84-2
Synonyms: D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride
Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
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12
12 Cited Publications
Cat. No.: HY-N0487
CAS No.: 29031-19-4
Synonyms: D-Glucosamine sulfate
Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
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7
7 Cited Publications
Cat. No.: HY-113596
CAS No.: 102029-73-2
Purity:  99.22%
Synonyms: Acetyl-CoA trisodium
Acetyl-coenzyme A (Acetyl-CoA) trisodium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trisodium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trisodium is also a key precursor of lipid synthesis .
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7
7 Cited Publications
Cat. No.: HY-113596A
CAS No.: 32140-51-5
Purity:  97%
Synonyms: Acetyl-CoA lithium
Acetyl-coenzyme A (Acetyl-CoA) lithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A lithium, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A lithium is also a key precursor of lipid synthesis .
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5
5 Cited Publications
Cat. No.: HY-B0417A
CAS No.: 859-18-7
Synonyms: U10149A
Lincomycin hydrochloride (U10149A) is an orally active lincosamide antibiotic. Lincomycin hydrochloride binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice .
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5
5 Cited Publications
Cat. No.: HY-117660
CAS No.: 154-21-2
Purity:  99.82%
Synonyms: U-10149
Lincomycin (U-10149) is an orally active lincosamide antibiotic. Lincomycin binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice .
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5
5 Cited Publications
Cat. No.: HY-B1358
CAS No.: 7179-49-9
Synonyms: U-10149 hydrochloride monohydrate
Lincomycin (U-10149) hydrochloride monohydrate is an orally active lincosamide antibiotic. Lincomycin hydrochloride monohydrate binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride monohydrate can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride monohydrate induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice .
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5
5 Cited Publications
Cat. No.: HY-N9933
CAS No.: 25696-60-0
Synonyms: TβMCA
Tauro-β-muricholic acid (TβMCA) is an orally active trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC50=40 μM). Tauro-β-muricholic acid inhibits bile acid-induced hepatocyte apoptosis by maintaining mitochondrial membrane potential, while simultaneously inhibiting intestinal FXR signaling, affecting bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity. Accumulation of tauro-β-muricholic acid disrupts metabolic homeostasis, promoting cancer stem cell proliferation and tumor progression. The mechanisms of tauro-β-muricholic acid involve two aspects: first, inhibiting the translocation of the pro-apoptotic protein Bax to mitochondria and maintaining mitochondrial membrane potential (MMP); and second, blocking the FXR signaling pathway to regulate bile acid metabolism, reduce serum ceramide production, and downregulate the hepatic SREBP1C/CIDEA pathway. Tauro-β-muricholic acid possesses anti-hepatocyte apoptosis, bile acid homeostasis regulation, and liver fat accumulation reduction properties, and also functions as a biomarker, making it useful in the study of diseases such as bile acid metabolism disorders, non-alcoholic fatty liver disease, colorectal cancer, and liver fibrosis .
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4
4 Cited Publications
Cat. No.: HY-140740
Purity:  99.48%
Target:  

Liposome

Research Areas:  

Others

DSPE-PEG5000-Maleimide, is a linker lipid containing DSPE phospholipid and Maleimide. DSPE-PEG-Maleimide is used in the synthesis of liposomes, including HELDC liposomes, sterically stabilized liposomes, and immunoliposomes .
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4
4 Cited Publications
Cat. No.: HY-113402
CAS No.: 636-58-8
Purity:  95.20%
Synonyms: γ-Glu-Cys
Gamma-glutamylcysteine (γ-Glu-Cys) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease .
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4
4 Cited Publications
Cat. No.: HY-113402A
CAS No.: 283159-88-6
Purity:  95.20%
Synonyms: γ-Glu-Cys TFA
Gamma-glutamylcysteine TFA (γ-Glu-Cys TFA) is an orally active, blood-brain barrier permeable dipeptide . Gamma-glutamylcysteine TFA activates AMPK, SIRT1, IL-4/STAT6, AC/cAMP/PI3K, IGF-1R/IRS1/PI3K, and Nrf2 signaling pathways; it inhibits NF-κB, JAK1/STAT1/3, MAPKs, cadmium-induced p38 MAPK, JNK, and PI3K/Akt signaling pathways. Gamma-glutamylcysteine TFA regulates macrophage polarization, modulates the trafficking of CD36 and GLUT4, induces glutathione synthesis, improves metabolic dysfunction, reduces lipid deposition, ameliorates glucose homeostasis, inhibits apoptosis (Apoptosis), stabilizes mitochondria, suppresses lipid peroxidation, iron accumulation and ferroptosis (Ferroptosis), reduces ds-HMGB1 levels, reverses mechanical hyperalgesia, and alleviates hepatic lipid droplet formation. Gamma-glutamylcysteine TFA is applicable to research related to inflammatory bowel disease, type 2 diabetes, cadmium-induced neurotoxicity, Alzheimer's disease, cerebral ischemia/reperfusion injury, neuropathy, and alcoholic liver disease .
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3
3 Cited Publications
Cat. No.: HY-N7264
CAS No.: 566-26-7
7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. 7α-Hydroxycholesterol has cytotoxic and pro-inflammatory activities. 7α-Hydroxycholesterol can also inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis .
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3
3 Cited Publications
Cat. No.: HY-Y0850O
CAS No.: 9002-89-5
Synonyms: PVA (Mw 31000-50000, 87-89% hydrolyzed); Poly(Ethenol) (Mw 31000-50000, 87-89% hydrolyzed)
Polyvinyl alcohol (PVA; Poly (Ethenol)) (Mw 31000-50000, 87-89% hydrolyzed) is a polymer with emulsifying and stabilizing properties, with a degree of hydrolysis of 87-89%. Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) mainly acts as a stabilizer in the preparation of nanomedicines; it not only maintains the structural integrity of PEGylated PLGA nanoparticles during double emulsion synthesis, but also facilitates the preparation of chitosan/matrine-PLGA nanoparticle aqueous solutions and lipid-polymer nanoparticles. Polyvinyl alcohol (Mw 31000-50000, 87-89% hydrolyzed) can be widely used in research related to fields such as breast cancer .
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2
2 Cited Publications
Cat. No.: HY-N0656
CAS No.: 125-46-2
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .
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2
2 Cited Publications
Cat. No.: HY-Y1139
CAS No.: 111-16-0
Synonyms: Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid
Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism .
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2
2 Cited Publications
Cat. No.: HY-109056
CAS No.: 868046-19-9
Purity:  99.90%
Synonyms: R-1206
Elsulfavirine (R-1206) is an orally active human carbonic anhydrase (carbonic anhydrase, CA) inhibitor and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). Elsulfavirine also targets and blocks the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocks SREBP-1-mediated de novo lipid synthesis, and inhibits the proliferation of liver cancer cells. The combination of Elsulfavirine and Lenvatinib (HY-10981) produces a synergistic anti-tumor effect. Elsulfavirine is converted into the active metabolite VM1500A in vivo, blocks the DNA polymerase activity of reverse transcriptase, and inhibits HIV-1 replication. Elsulfavirine exhibits a Ki of 1960 nM-52400 nM against human carbonic anhydrase isoforms including I, VII, VI, VA, VB, IX, XIII, XIV. Elsulfavirine is used in studies related to HIV-1 infection and liver cancer .
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1
1 Cited Publications
Cat. No.: HY-125924
CAS No.: 474922-26-4
Purity:  99.96%
Synonyms: DSPE-PEG-NH2, MW 2000 ammonium; DSPE-PEG(2000) Amine ammonium
Target:  

Drug Derivative

Research Areas:  

Cancer

DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents .
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1
1 Cited Publications
Cat. No.: HY-23524
CAS No.: 346656-34-6
Target:  

Lipase

Research Areas:  

Metabolic Disease

HSL-IN-3 is a HSL inhibitor. HSL-IN-3 serves as an important intermediate for the synthesis of PARP-1 inhibitors. HSL-IN-3 can be used in studies related to lipid metabolism .
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