154-21-2
154-21-2
Chemical Structure
Lincomycin
Synonym(s): U-10149
- CAS No.: 154-21-2
- Formula:C18H34N2O6S
- Molecular Weight:406.54
IUPAC Name: (2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
InChIKey: OJMMVQQUTAEWLP-KIDUDLJLSA-N
SMILES: O=C([C@@H]1C[C@H](CN1C)CCC)N[C@@H]([C@@]2([H])O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)SC)[C@H](O)C
Biological Activity: Lincomycin (U-10149) is an orally active lincosamide antibiotic. Lincomycin binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Lincomycin | 99.82% | Lincomycin (U-10149) is an orally active lincosamide antibiotic. Lincomycin binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice. | ||||||||||||||||||||
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Lincomycin (Standard) | ≥98% | Lincomycin (U-10149) (Standard) is the analytical reference standard of Lincomycin (HY-117660). This product is used for research and analytical applications. Lincomycin is an orally active lincosamide antibiotic. Lincomycin binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice. | ||||||||||||||||||||
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Lincomycin-13C,d3 | Lincomycin-13C,d3 (U-10149-13C,d3) is the deuterium and 13C-labeled Lincomycin (HY-117660). Lincomycin (U-10149) is an orally active lincosamide antibiotic. Lincomycin binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice. | |||||||||||||||||||||
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Lincomycin-d3 | 99.90% | Lincomycin-d3 (U-10149-d3) is the deuterium labeled Lincomycin. Lincomycin is an orally active lincosamide antibiotic. Lincomycin binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice. | ||||||||||||||||||||
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Lincomycin B | 99.93% | Lincomycin B is an antibiotic that can be isolated from Streptomyces lincolnensis. | ||||||||||||||||||||
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7-Epiclindamycin | 7-Epiclindamycin is a common impurity in Clindamycin (HY-B1455) bulk agent. 7-epiclindamycin is produced during the synthesis of Clindamycin. | |||||||||||||||||||||
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Clindamycin hydrochloride | 99.91% | Clindamycin (hydrochloride) is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal. | ||||||||||||||||||||
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Lincomycin hydrochloride | 99.59% | Lincomycin hydrochloride (U10149A) is an orally active lincosamide antibiotic. Lincomycin hydrochloride binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice. | ||||||||||||||||||||
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Lincomycin hydrochloride monohydrate (Standard) | ≥98% | Lincomycin (U-10149) hydrochloride monohydrate (Standard) is the analytical standard of Lincomycin hydrochloride monohydrate (HY-B1358). This product is intended for research and analytical applications. Lincomycin hydrochloride monohydrate is an orally active lincosamide antibiotic. Lincomycin hydrochloride monohydrate binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride monohydrate can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride monohydrate induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice. | ||||||||||||||||||||
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Clindamycin (Standard) | ≥98% | Clindamycin (Standard) is the analytical standard of Clindamycin. This product is intended for research and analytical applications. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria. | ||||||||||||||||||||
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Clindamycin hydrochloride monohydrate | 98.42% | Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). | ||||||||||||||||||||
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Lincomycin impurity 1 | Lincomycin impurity 1 is an impurity of Lincomycin. | |||||||||||||||||||||
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7-Epi lincomycin hydrochloride | 7-Epi lincomycin (hydrochloride) is a kind of biochemical reagent. | |||||||||||||||||||||
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Lincomycin impurity 4 | Lincomycin impurity 4 is an impurity of Lincomycin. | |||||||||||||||||||||
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References
- [1]. Veciana N, et al. BBX16 mediates the repression of seedling photomorphogenesis downstream of the GUN1/GLK1 module during retrograde signalling. New Phytol. 2022;234(1):93-106. [Content Brief]
- [2]. Imai Y, et al. Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp. Appl Environ Microbiol. 2015;81(11):3869-3879. [Content Brief]
- [3]. Ni H, et al. Lincomycin as a growth-promoting antibiotic induces metabolic and immune dysregulation in animals. Sci Total Environ. 2024;957:177780. [Content Brief]
