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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
microenvironment sensing
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "microenvironment sensing" in MCE Product Catalog:
Target:
Cat. No.: HY-D0074
CAS No.: 70504-01-7
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Prodan is an environment-sensitive fluorescent probe used to investigate the polarity, fluidity, and structure of lipid membranes. Prodan exhibits environment-dependent excitation/emission wavelengths, with its wavelength range covering Ex = 360-410 nm and Em = 430-530 nm when in solvents, bound to DNA, located in lipid bilayers, or associated with proteins. Prodan can interact with the major groove of DNA, regions of lipid bilayers, and hydrophobic pockets of proteins. During phase transitions, Prodan localizes to different regions of the bilayer: the emission minimum is 430-440 nm in the gel phase, while it shifts to 480-500 nm in the liquid-crystalline phase or interdigitated gel phase. When bound to rigid hydrophobic sites of proteins, the emission peak of Prodan undergoes a blue shift and its fluorescence intensity increases .
Cat. No.: HY-Y1309S1
CAS No.: 124251-84-9
Synonyms: Furro ER-d7; NSC 9586-d7; Nako TRB-d7
Cat. No.: HY-D2992
Cat. No.: HY-172754
Cat. No.: HY-D3090
CAS No.: 2757682-04-3
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NRLD is a lipid droplet-targeting solvatochromic fluorescent probe developed based on Nile Red (HY-D0718), which can target lipid droplets and sense the non-polar lipid microenvironment inside lipid droplets. NRLD exhibits superior lipid droplet-targeting selectivity compared to the parent Nile Red dye in HeLa cell imaging. NRLD achieves detection relying on the solvatochromic effect generated by excited-state charge transfer, and its emission wavelength shifts according to the local polarity changes of the microenvironment it locates in: the more compact and ordered the lipid packing and the lower the environmental polarity, the more blue-shifted the emission; the looser the lipid packing or the stronger the hydration and the higher the environmental polarity, the more red-shifted the emission. NRLD shows blue shift in the non-polar oil core of lipid droplets and red shift in high-polarity environments such as phosphate buffer .
Cat. No.: HY-D3351
CAS No.: 2668963-61-7
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Research Areas:
PNO1 is a fluorescent probe for pulmonary fibrosis detection. The detection mechanism of PNO1 relies on sensing upregulated nitric oxide (NO) in the pulmonary fibrosis (PF) microenvironment. PNO1 contains an aniline group that reacts with NO or its derivatives under acidic conditions to form an N-nitrosylated intermediate, which is subsequently converted into a diazonium salt and undergoes deamination, eliminating the intramolecular electron transfer quenching effect and triggering a fluorescence turn-on response. The excitation wavelength of PNO1 includes 545 nm in in vitro solution studies, while an excitation range of 520-550 nm is used for cell, tissue and in vivo imaging; its emission wavelength centers at 572 nm in the unreacted state, and shifts to 559 nm with enhanced fluorescence intensity upon binding to NO. PNO1 can be used for pulmonary fibrosis research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
