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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
morpholino
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "morpholino" in MCE Product Catalog:
1
1 Cited Publications
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NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity . NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM . NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM . NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM) . NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability .
Synonyms: AVI 4658
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Eteplirsen (AVI 4658) is a phosphorylated diamine morpholino oligonucleotide that targets exon 51 of the human Duchenne muscular dystrophy (DMD) gene. Eteplirsen induces exon 51 skipping, causing it to be skipped during splicing, thereby restoring the translation reading frame and producing a shortened functional dystrophin. Eteplirsen can be used in research on Duchenne muscular dystrophy .
Synonyms: SRP-4053
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Golodirsen (SRP-4053) is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen can restore the expression of the anti-myostatin protein. Golodirsen can be used for the research of duchenne muscular dystrophy (DMD) .
Cat. No.: HY-P990051
CAS No.: 2653183-66-3
Synonyms: AOC-1001 Antibody; AOC-1044 Antibody
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Cat. No.: HY-132586
CAS No.: 2055732-84-6
Synonyms: NS-065/NCNP-01
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Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen has the potential for Duchenne muscular dystrophy (DMD) research .
Cat. No.: HY-108753A
Purity: 91.16%
Synonyms: AVI 4658 sodium
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Eteplirsen (AVI 4658) sodium is a phosphorylated diamine morpholino oligonucleotide that targets exon 51 of the human Duchenne muscular dystrophy (DMD) gene. Eteplirsen sodium induces exon 51 skipping, causing it to be skipped during splicing, thereby restoring the translation reading frame and producing a shortened functional dystrophin. Eteplirsen sodium can be used in research on Duchenne muscular dystrophy .
Cat. No.: HY-132611A
Purity: 92.00%
Synonyms: SRP-4053 sodium
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Golodirsen (SRP-4053) sodium is an antisense oligonucleotide of the phophorodiamidate morpholino oligomer (PMO). Golodirsen sodium restores the reading frame of the Duchenne muscular dystrophy (DMD) gene by modifying the splicing process of the pre-mRNA, skipping exon 53. Golodirsen sodium can restore the expression of the anti-myostatin protein. Golodirsen sodium can be used for the research of duchenne muscular dystrophy (DMD) .
Cat. No.: HY-132586A
Purity: 95.25%
Synonyms: NS-065/NCNP-01 sodium
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Viltolarsen (NS-065/NCNP-01) sodium is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen sodium binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen sodium has the potential for Duchenne muscular dystrophy (DMD) research .
Cat. No.: HY-177363
CAS No.: 2243974-81-2
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Morpholino G phosphoramidite (Compound 4b) is a nucleoside building block that is used for synthesis of morpholino oligonucleotides. Morpholino G phosphoramidite can be used for oligonucleotide therapies research .
Cat. No.: HY-W047388
CAS No.: 6291-16-3
Cat. No.: HY-W048487
CAS No.: 139290-78-1
Synonyms: N6-Benzoyl-7'-OH-morpholino adenosine
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N6-Benzoyl-7’-OH-morpholino adenine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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RNA, [P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-Am5U-m5U-m5U-C-m5U-A-[2'a-(N2-acetyl-L-arginyl-L-arginyl-L-arginyl-Larginyl-L-arginyl-L-arginylglycyl)]G), 5'-[P-[4-[[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]carbonyl]-1-piperazinyl]-N,Ndimethylphosphonamidate], sodium salt
Cat. No.: HY-132585A
Synonyms: SRP-5051 sodium
Cat. No.: HY-17652
CAS No.: 1037305-43-3
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Morpholino T phosphoramidite is a nucleoside building block that has been used in the synthesis of morpholino oligonucleotides .
Cat. No.: HY-177385
CAS No.: 2304678-30-4
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Morpholino C phosphoramidite (Compound 4c) is a nucleoside building block that can be used for synthesis of morpholino oligonucleotides. Morpholino C phosphoramidite can be used for oligonucleotide therapies research .
Cat. No.: HY-17653
CAS No.: 2243974-80-1
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Morpholino A phosphoramidite is a specialized chemical building block used to synthesize Phosphorodiamidate Morpholino Oligomers (PMOs). Morpholino A phosphoramidite contains the adenine (A) nucleobase attached to a morpholine ring, fitted with a phosphoramidite group. PMOs are synthetic gene knockdown tools heavily used in developmental biology and targeted therapeutics to inhibit gene expression or alter RNA splicing .
Cat. No.: HY-132584A
Purity: 99.07%
Synonyms: SRP-4045 sodium
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Casimersen (SRP-4045) sodium is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen sodium binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen sodium can be used for the research of Duchenne muscular dystrophy (DMD) .
Cat. No.: HY-P10559
CAS No.: 879010-15-8
Cat. No.: HY-154706
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N-DMTr-Morpholino-T-5'-O-phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
Cat. No.: HY-171618
CAS No.: 2388517-98-2
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Morpholino U subunit is one of the basic units that make up morpholino oligonucleotides. Morpholino U subunit can pair with adenine in the target RNA .
Cat. No.: HY-P10559A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
