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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
nef
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "nef" in MCE Product Catalog:
5
Target:
Research Areas:
R(+)-Methylindazone (R(+)-IAA-94) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-Methylindazone inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef) .
1
1 Cited Publications
Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC50s of 2.8 μM, >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC50 of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity .
1
1 Cited Publications
Cat. No.: HY-P71276
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: S100B; S100 Calcium-Binding Protein B; S100 Calcium Binding Protein B; S100 Calcium-Binding Protein; S100beta; S-100 Protein Beta Chain; S-100 Protein Subunit Beta; Protein S100; Protein S100-B; S100-B; S100 Calcium Binding Protein, Beta (Neural); S100; S100 Calcium-Binding Protein, Beta (Neural); nef; S-100 Calcium-Binding Protein, Beta Chain
Species:
Mouse
Source:
E. coli
Cat. No.: HY-171860
CAS No.: 3066894-28-5
FC-14369 is a PROTAC degrader targeting the HIV-1 Nef protein, with a DC50 value of 160 nM. Through its bifunctional structure, FC-14369 binds to Nef and the Cereblon E3 ubiquitin ligase, induces Nef ubiquitination and proteasomal degradation, restores the expression of cell-surface CD4 and MHC-I, and inhibits HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS. FC-14369 is applicable to studies related to HIV-1 infection .
Cat. No.: HY-P2260B
Cat. No.: HY-160267
CAS No.: 950403-60-8
Target:
Research Areas:
iPAF1C is a inhibitor of the polymerase-associated factor 1 complex (PAF1C) with specific targeting to the PAF1 binding groove of CTR9 (a key subunit of PAF1C). iPAF1C disrupts PAF1C assembly by interfering with the PAF1-CTR9 interaction. iPAF1C selectively impairs BRD4-mediated recruitment of PAF1 to chromatin at hypoxia-responsive genes and inhibits RNA polymerase II (RNAPII) pause release. iPAF1C increases the population of HIV-1 NL4.3 Nef-IRES-GFP infected primary human CD4 +T cells in a dose-dependent manner. PAF1C can be used for the study of infection and diseases associated with abnormal hypoxic adaptation (e.g., cancers, neurological disorders) .
HIV-1 Nef-IN-1 is an HIV-1 Nef protein inhibitor that efficiently competes for Nef-SH3Hck interactions with a Kd of 6.7 μM .
Cat. No.: HY-171862
CAS No.: 3066896-28-1
Research Areas:
Nef ligand-2 is a binder of Nef. Nef ligand-2 is Ligands for E3 Ligase. Nef ligand-2 is the Nef Binder portion of FC-14369 (HY-171860) .
Cat. No.: HY-P10971
CAS No.: 860401-80-5
Cat. No.: HY-P2260C
Cat. No.: HY-171859
CAS No.: 3066893-65-7
FC-14367 is a PROTAC degrader targeting the HIV-1 Nef protein. FC-14367 forms a ternary complex between HIV-1 Nef and CRBN, inducing ubiquitination and proteolytic degradation of Nef. FC-14367 restores the expression of CD4 and MHC-I on the cell surface and inhibits Nef-dependent enhancement of HIV-1 replication. FC-14367 can be used in studies related to HIV-1 infection .
Cat. No.: HY-171861
CAS No.: 2416170-64-2
Nef ligand-1 is the Nef binding part of FC-14367 (HY-171859) .
Cat. No.: HY-119210
CAS No.: 364052-84-6
ZINC04177596 is a potent HIV-negative factor (HIV-Nef) protein inhibitor. Nef is an accessory gene product of HIV and has an imperative role in viral replication and AIDS pathogenesis .
Cat. No.: HY-120465
CAS No.: 1174905-91-9
ZINC36617540 is a novel Nef protein inhibitor with anti-HIV activity. ZINC36617540 exhibits superior binding affinity by binding to Nef protein. ZINC36617540 shows a similar binding mode to the prototype molecule B9 in molecular docking. The mechanism of action of ZINC36617540 mainly depends on its hydrophobic and electrostatic interactions with Nef protein .
Cat. No.: HY-RS12387
Target:
Research Areas:
S100B Human Pre-designed siRNA Set A contains three designed siRNAs for S100B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P83943A
Synonyms: nef; S100; S100beta
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
