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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
non-enzymatic protein
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "non-enzymatic protein" in MCE Product Catalog:
Cat. No.: HY-NP165
Synonyms: AGEs
Cat. No.: HY-151886
CAS No.: 2759420-43-2
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NU223612 is a cereblon (CRBN)-recruiting IDO1 PROTAC degrader, with a DC50 value of 0.329-0.5438 μM against human IDO1, and it is capable of penetrating the blood-brain barrier. NU223612 directly binds to IDO1, mediates the degradation of both wild-type and catalytically inactive mutant IDO1 proteins, and does not degrade TDO2. NU223612 inhibits IDO1-mediated enzymatic activity. NU223612 directly binds to CRBN and promotes the formation of a cooperative ternary complex with IDO1. NU223612 induces ubiquitin-dependent proteasomal degradation of the IDO1 protein. NU223612 suppresses IDO1-mediated non-enzymatic phosphorylation of NF-κB p65 and the DNA-binding activity of downstream transcription factors. NU223612 can be used in studies of glioblastoma (malignant glioma) .
Cat. No.: HY-131920A
CAS No.: 28086-43-3
Synonyms: Polyuridylic acid potassium
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Cat. No.: HY-141508
CAS No.: 100041-05-2
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RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM), stabilizes the interaction between RECQL5-RAD51 proteins, causes RAD51 aggregation and homologous recombination repair (HRR) inhibition, thereby exhibiting selective cytotoxicity in RECQL5-expressing cancer cells .
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Cat. No.: HY-W035399S
Cat. No.: HY-W035399S1
CAS No.: 2708340-91-2
Cat. No.: HY-Y1804S
CAS No.: 2714413-18-8
Cat. No.: HY-23201
CAS No.: 1035557-09-5
Synonyms: Phytoprostane A1; PPA1
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A1-Phytoprostane-I (Phytoprostane A1) is a cyclopentenone-type phytoprostane that forms via free radical-catalyzed non-enzymatic oxidation of α-linolenic acid. A1-Phytoprostane-I exhibits multiple biological activities, including inducing the accumulation of phytoalexins (e.g., Scopoletin (HY-N0342)) in tobacco cells, activating mitogen-activated protein kinases (MAPK) in tomato cells, and inducing the expression of glutathione-S-transferase 1 (Glutathione-S-transferase 1) in Arabidopsis thaliana .
Cat. No.: HY-106621A
CAS No.: 158513-06-5
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AL 0671 is a potassium channel opener. AL 0671 can inhibit nonenzymatic glycation of protein and LDL oxidation. AL 0671 can be used for the researches of cardiovascular and metabolic disease, such as hypertensive diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
