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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
non-muscle myosin II
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "non-muscle myosin II" in MCE Product Catalog:
49
49 Publications Verification
Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration .
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29 Cited Publications
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(-)-Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II .
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1 Cited Publications
(+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective inhibitor of non-muscle myosin II ATPase activity .
Cat. No.: HY-175188
CAS No.: 2404652-82-8
Synonyms: BPN-0027490
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MT-110 (BPN-0027490) is a non-muscle myosin NMIIB-selective inhibitor with high brain penetration and favorable safety profile. MT-110 specifically disrupts NMIIB-dependent actin dynamics in dendritic spines, while it exerts no significant adverse effects on cardiac myosin II and cardiac functions (such as cardiac output and heart rate) at tested concentrations. A single administration of MT-110 produces long-lasting (sustained for several weeks) blockade of methamphetamine motivation associated with environmental cues. MT-110 exhibits extremely high specificity, with no interference with cocaine motivation, hippocampus-dependent memory, fear memory, or locomotor and anxiety-like behaviors. MT-110 serves as a valuable tool compound for investigating the mechanisms of methamphetamine use disorder .
Cat. No.: HY-175199
CAS No.: 2404652-24-8
Synonyms: BPN-0026709
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MT-228 (BPN-0026709) is a selective and blood-brain barrier permeable non-muscle myosin II inhibitor. MT-228 markedly improves tolerability by selectively targeting NMIIB (KI = 1.5 μM) over CMII (KI = 17 μM), and the sequence of SmMll MD is 83.6% identical to that of NMllB. MT-228 shows long-lasting efficacy in animal models of stimulant use disorder .
JB061 is a nonmuscle myosin inhibitor with IC50s of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II), respectively. JB061 poorly decreases ATPase activity (IC50>200 μM). JB061 shows cytotoxicity against COS-7 cells with an IC50 value of 39 μM .
Cat. No.: HY-133885
CAS No.: 856925-75-2
Cat. No.: HY-13441G
CAS No.: 856925-71-8
Cat. No.: HY-13813R
CAS No.: 674289-55-5
Blebbistatin (Standard) is the analytical standard of Blebbistatin. This product is intended for research and analytical applications. Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration .
Cat. No.: HY-133885A
CAS No.: 1217619-62-9
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R-(-)-7-Desmethyl-8-nitro blebbistatin is an analog of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective non-muscle myosin II inhibitor.
Cat. No.: HY-152206
CAS No.: 2417988-00-0
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JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .
Cat. No.: HY-13441R
CAS No.: 856925-71-8
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(-)-Blebbistatin (Standard) is the analytical standard of (-)-Blebbistatin (HY-13441). This product is intended for research and analytical applications. (-)-Blebbistatin is a selective inhibitor of the ATPase activity of non-muscle myosin II .
Cat. No.: HY-107657R
CAS No.: 1177356-70-5
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(+)-Blebbistatin (Standard) is the analytical standard of (+)-Blebbistatin (HY-107657). This product is intended for research and analytical applications. (+)-Blebbistatin is the inactive enantiomer of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective inhibitor of non-muscle myosin II ATPase activity .
Cat. No.: HY-W776974
CAS No.: 1217635-67-0
(R)-(+)-Blebbistatin O-Benzoate is a non-muscle myosin II selective inhibitor. (R)-(+)-Blebbistatin O-Benzoate is a derivative of Blebbistatin (HY-13813). (R)-(+)-Blebbistatin O-Benzoate blocks cell membrane bubbling and interferes with directed migration and cytokinesis in vertebrate cells. (R)-(+)-Blebbistatin O-Benzoate inhibits the contraction of mitotic grooves. (R)-(+)-Blebbistatin O-Benzoate can be used as a negative control for (S)-(-)-Blebblastatin .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
