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organic cation transporter 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Dopamine Receptor (2) Drug Metabolite (1)
By Research Areas:	Metabolic Disease (2) Neurological Disease (1)

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Targets Recommended: OAT MOFs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2003

D-Tetrahydropalmatine 1 Publications Verification	Dopamine Receptor	Metabolic Disease
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis . D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor .

HY-100057

BMY 28674 6-Hydroxybuspirone; 6'-Hydroxybuspirone; BMS 528215	5-HT Receptor Drug Metabolite Dopamine Receptor	Neurological Disease
BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC₅₀s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC₅₀s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits **organic cation transporter 1** (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.

HY-180396

Ikarisoside B	Others	Metabolic Disease
Ikarisoside B is a potent and selective Organic cation transporter 1 (OCT1) inhibitor with an IC₅₀ of 11.18 μM. Ikarisoside B shows selectivity over OCT2 (IC₅₀ = 56.54 μM). Ikarisoside B can be used for the research of metabolic disease .

D-Tetrahydropalmatine 1 Publications Verification	Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Dopamine Receptor
D-Tetrahydropalmatine is an isoquinoline alkaloid, mainly in the genus Corydalis . D-Tetrahydropalmatine is a dopamine (DA) receptor antagonist with preferential affinity toward the D1 receptors . D-Tetrahydropalmatine is a potent organic cation transporter 1 (OCT1) inhibitor .

Ikarisoside B	Structural Classification Flavonols Flavonoids Epimedium koreanum Nakai Plants Berberidaceae Source Classification	Others
Ikarisoside B is a potent and selective Organic cation transporter 1 (OCT1) inhibitor with an IC₅₀ of 11.18 μM. Ikarisoside B shows selectivity over OCT2 (IC₅₀ = 56.54 μM). Ikarisoside B can be used for the research of metabolic disease .

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3)
Application:	WB (3) FC (1) ELISA (2)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85379

	SYK Antibody (YA5071) SLC22A1; OCT1; Solute carrier family 22 member 1; organic cation transporter 1; hOCT1	WB, ELISA	Human
	SYK Antibody (YA5071) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SYK.

HY-P85379A

	SYK Antibody (YA5071)(PBS only) SLC22A1; OCT1; Solute carrier family 22 member 1; organic cation transporter 1; hOCT1	WB, ELISA	Human
	SYK Antibody (YA5071) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SYK.

HY-P85303

	SLC22A1/OCT1 Antibody (YA4995) SLC22A1; OCT1; Solute carrier family 22 member 1; organic cation transporter 1; hOCT1	WB, FC	Human
	SLC22A1/OCT1 Antibody (YA4995) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to SLC22A1/OCT1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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organic cation transporter 1

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