5 Results for "

pH2AX

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "pH2AX" in MCE Product Catalog:

10
THAL-SNS-032
THAL-SNS-032
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10 Cited Publications
Cat. No.: HY-123937
CAS No.: 2139287-33-3
Purity:  99.16%
Target:  

PROTACs CDK Apoptosis CMV SARS-CoV Caspase

Research Areas:  

Infection Cancer

THAL-SNS-032 is a selective CDK9 PROTAC degrader. THAL-SNS-032 recruits CRBN to form a ternary complex with CDK9, thereby triggering ubiquitination and proteasomal degradation of CDK9. THAL-SNS-032 also induces the degradation of CDK1, CDK2 and CDK7. THAL-SNS-032 elevates pH2AX levels, reduces MCL1s expression, and activates caspase-3. THAL-SNS-032 induces cancer cell apoptosis, regulates transcription, and inhibits the replication of human cytomegalovirus (CMV) and SARS-CoV-2. THAL-SNS-032 can be used in research related to breast cancer, leukemia, cytomegalovirus infection and SARS-CoV-2 infection [2] .
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3
Mollugin
Mollugin
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3 Cited Publications
Cat. No.: HY-N0316
CAS No.: 55481-88-4
Category:  

Monophenols Terpenoids Sesquiterpenes Rubiaceae Phenols Plants Disease Research Fields Cancer Rubia cordifolia L.

Target:  

JAK NF-κB Reactive Oxygen Species (ROS) Apoptosis VEGFR c-Myc

Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway [2] .
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PAA5
PAA5
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Cat. No.: HY-149036
Category:  

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

Ferroptosis Endogenous Metabolite Reactive Oxygen Species (ROS)

PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity .
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Mollugin (Standard)
Mollugin (Standard)
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Cat. No.: HY-N0316R
CAS No.: 55481-88-4
Category:  

Monophenols Terpenoids Sesquiterpenes Rubiaceae Phenols Plants Rubia cordifolia L.

Target:  

JAK Reference Standards NF-κB Reactive Oxygen Species (ROS) Apoptosis VEGFR c-Myc

Mollugin (Standard) is the analytical standard of Mollugin. This product is intended for research and analytical applications. Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway [2] .
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JHD205
JHD205
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Cat. No.: HY-162985
Target:  

CDK

Research Areas:  

Cancer

JHD205 is a CDK4/6 inhibitor that induces apoptosis and DNA damage. JHD205 inhibits DNA repair by upregulating Caspase3 and p-H2AX. JHD205 has superior potency to Abemaciclib (HY-16297A) in a xenograft chick embryo breast cancer model. .
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