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27 Results for "
phosphatidylethanolamine lipid
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "phosphatidylethanolamine lipid" in MCE Product Catalog:
1
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
Cat. No.: HY-112747
CAS No.: 97281-51-1
Synonyms: LPI; PE (soy)
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Soy PE (LPI) is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively. It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide and is a source of ethanolamine used in various cellular functions. In E.coli, phosphatidylethanolamine deficiency prevents proper assembly of lactose permease, suggesting a role as a lipid chaperone. It is a cofactor in the propagation of prions in vitro and can convert recombinant mammalian proteins into infectious molecules even in the absence of RNA. This product contains phosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 and sn-2 positions .
DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane .
Synonyms: 16:0 PEG2000 PE ammonium; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium
DPPE-PEG2000 ammonium (16:0 PEG5000 PE) is a polymer-lipid conjugate and LipoParticle stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG2000 ammonium enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG2000 ammonium helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG2000 ammonium serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections .
Cat. No.: HY-D1602
CAS No.: 217075-07-5
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BODIPY FL-DHPE is a fluorescent lipid probe composed of phosphatidylethanolamine (DHPE) labeled with a BODIPY FL fluorophore, which is used for fluorescent labeling of cell membranes, differentiation between liposome membrane fusion and endocytic pathways, and studies of membrane dynamics. The two C16 alkyl chains of BODIPY FL-DHPE insert into the lipid bilayer of membranes, and its fluorescence exhibits concentration dependence: it exists as monomers and emits green fluorescence at low mole fractions; it forms dimers with a red-shifted emission peak at high mole fractions; this spectral change is independent of enzymes, pH, and membrane potential. When liposomes enter the plasma membrane via membrane fusion, the dye is diluted, leading to attenuation of the dimer peak and enhancement of the monomer peak; when entry occurs via endocytosis, the dye remains in endosomes at high concentration with no change in the dimer peak, allowing differentiation between the two uptake pathways. Ex = 488 nm; monomer Em = 515 nm, dimer Em ≈ 620 nm .
Cat. No.: HY-112768
Purity: ≥95.0%
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PEG2000-DMPE is a polyethylene glycol-lipid conjugate combined with phosphatidylethanolamine. PEG2000-DMPE undergoes a conformational transition from mushroom-like to brush-like at a concentration of 7 mol%, thereby exerting multiple functions such as inhibitor, stabilizer and surface defect modifier. PEG2000-DMPE can form a steric hindrance barrier on the vesicle surface to block calcium ion-induced liposome fusion, and dynamically regulate the fusion process through spontaneous transfer rate. PEG2000-DMPE can delay the thinning of foam thin liquid films and smoothly seal surface defects of solid support layers. PEG2000-DMPE can be used in the design and related research of stealth liposomes and micelles .
Synonyms: 9Z,11E-CLA; Methyl 9(Z),11(E)-octadecadienoate; (9Z,11E)-SFE 19:2
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9 (Z),11 (E)-Conjugated linoleic acid methyl ester (9Z,11E-CLA; Methyl 9 (Z),11 (E)-octadecadienoate; (9Z,11E)-SFE 19:2) is an isomer of Linoleic acid (HY-N0729), and is a conjugated linoleic acid mainly found in meat and dairy products. Conjugated linoleic acid is a bioactive fatty acid that improves body composition, enhances immune system function, and exhibits anti-cancer and anti-atherosclerotic effects .
Cat. No.: HY-174940
CAS No.: 1240502-50-4
Cat. No.: HY-N7327
CAS No.: 50276-96-5
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Cat. No.: HY-W013078
CAS No.: 998-07-2
Synonyms: DMPE
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Cat. No.: HY-W800805
CAS No.: 2295813-15-7
DOPE-Mal is an N-maleimide-derived phosphatidylethanolamine. DOPE-Mal does not interfere with fatty acyl chains or alter lipid bilayer permeability; it increases lipid bilayer order, reduces fluidity, induces conformational changes in phospholipid polar heads and enhances their hydration. DOPE-Mal can be used as a component to prepare maleimide-displaying liposomes, enabling peptide conjugation via maleimide-thiol coupling. DOPE-Mal can be used to prepare Liposomes for delivering Doxorubicin (HY-15142A) to hepatocytes. DOPE-Mal is applicable to research related to hepatocellular carcinoma and lung cancer .
Cat. No.: HY-D1556
CAS No.: 384832-91-1
Synonyms: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) ammonium
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18:1 PE CF (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium)) is a pH-sensitive fluorescent indicator. 18:1 PE CF exhibits changes in fluorescence intensity in response to pH variations and reflects the electrostatic states of cationic liposomes and lipoplexes. 18:1 PE CF supports real-time visualization of pH distribution and membrane deformation in giant unilamellar vesicles and is suitable for steady-state fluorescence testing in large unilamellar vesicle membranes. 18:1 PE CF is capable of monitoring the surface electrical potential of cationic liposomes and lipoplexes and can effectively label lipid bilayers and nanomicelles. 18:1 PE CF can be used for the research of the investigation of lung cancer (Ex = 495 nm; Em = 520 nm) .
Cat. No.: HY-166874
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DSPE-PEG2000-endo-BCN is a PEG-lipid conjugate and distearyl phosphatidylethanolamine-polyethylene glycol (DSPE-PEG) derivative. DSPE-PEG2000-endo-BCN improves the delivery efficiency and tissue specificity of poorly soluble drugs and can be used in drug delivery research .
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DMABA NHS ester can chemically react with the primary amine groups of the major phospholipid component of the cell membrane, Phosphatidylethanolamine (PE). Through precursor ion scanning, all PE subclasses labeled with DMABA can be detected. DMABA NHS ester can be used in combination with isotope-labeled compounds such as DMABA-d6 NHS ester, DMABA-d10 NHS ester, and DMABA-d4 NHS ester to observe changes in the distribution of PE lipids and the formation of novel PE lipid products .
Cat. No.: HY-165895
CAS No.: 109032-52-2
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1,2-Dipentadecanoyl-sn-glycero-3-phosphatidylethanolamine is a phospholipid and can be used in the preparation of lipid nanoparticles.
Cat. No.: HY-W013078S
CAS No.: 326495-41-4
Synonyms: DMPE-d54
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1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE)-d54 is the deuterated-labeled 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) (HY-W013078). 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) is a zwitterionic saturated phosphatidylethanolamine bearing two myristoyl (C14:0) chains, and serves as a model membrane component, a neutral lipid component of lipid nanoparticles, and a cocoa butter crystallization nucleating agent. 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine is used in nucleic acid delivery, construction of artificial cell membrane models, and research on urothelial carcinoma .
Cat. No.: HY-W013078R
CAS No.: 998-07-2
Synonyms: DMPE (Standard)
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Cat. No.: HY-W127334
CAS No.: 108321-22-8
Cat. No.: HY-W020798
CAS No.: 98014-38-1
Cat. No.: HY-139050
CAS No.: 2260670-42-4
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16:0 DBCO PE ammonium is a functionalized lipid that combines the biocompatible properties of phosphatidylethanolamine (PE) with the reactive dibenzocyclooctyne (DBCO) group. 16:0 DBCO PE ammonium is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
