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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
protein phosphatase 2C
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "protein phosphatase 2C" in MCE Product Catalog:
Cat. No.: HY-E70629
Target:
Research Areas:
Protein phosphatase 2C is a serine-threonine phosphatase. Protein phosphatase 2C can dephosphorylate the key players of cell death pathways .
24
24 Publications Verification
Cat. No.: HY-N6785
CAS No.: 78111-17-8
Target:
24
24 Publications Verification
Cat. No.: HY-N6785A
CAS No.: 209266-80-8
Target:
Research Areas:
Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation .
24
24 Publications Verification
Cat. No.: HY-115760
CAS No.: 175522-42-6
Target:
Research Areas:
Okadaic acid ammonium salt, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid ammonium salt has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation .
1
1 Cited Publications
Synonyms: FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2
1
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
NSC45586 sodium is an inhibitor of PHLPP. NSC45586 sodium targets the PP2C phosphatase domains of PHLPP1 and PHLPP2, blocks the phosphatase activity of PHLPP, increases the expression level of FOXO1 in the nucleus, and reduces the protein expression of PHLPP1. NSC45586 sodium activates the AKT survival signaling pathway, enhances IGF-1-induced AKT activation, and inhibits the phosphorylation of AKT/ERK under basal conditions. NSC45586 sodium reduces staurosporine-induced neuronal death, preserves notochord cell morphology and KRT19 expression, inhibits cell apoptosis (apoptosis), improves the viability and proliferation of nucleus pulposus cells, upregulates the expression of ACAN/SOX9, and downregulates the expression of MMP13. NSC45586 sodium binds tightly to bovine serum albumin (bovine serum albumin), and exerts a more significant effect on nucleus pulposus in male individuals. NSC45586 sodium can be used in studies related to global cerebral ischemia and intervertebral disc degeneration .
1
1 Cited Publications
Cat. No.: HY-P75979
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPM1A; protein phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform; protein phosphatase, Mg2+/Mn2+ Dependent 1A; protein phosphatase, Mg2+/Mn2+ Dependent, 1A; protein phosphatase 1A; protein phosphatase 2C, Alpha Isoform; PP2Calpha; Alternati
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P700618
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PTPN11; protein Tyrosine phosphatase Non-Receptor Type 11 Isoform 1; Prev. NS1; Tyrosine-protein phosphatase Non-Receptor Type; SH-PTP2; protein-Tyrosine-phosphatase; PTP2C; Noonan Syndrome 1; BPTP3; CDNA, FLJ92431; SHP-2; PTPN11 protein; SHP2; METCDS; SH
Species:
Human
Source:
E. coli
Cat. No.: HY-120161
CAS No.: 1609660-14-1
Synonyms: 3'-Hexylsulfanylabscisic acid
Target:
Research Areas:
AS6 (3'-Hexylsulfanylabscisic acid) is a PYL antagonist with a Kd value of 0.48 μM for Arabidopsis PYL5. AS6 binds to PYL proteins, and its S-hexyl chain blocks PP2C binding via steric hindrance. AS6 alleviates the inhibitory effect of ABA on seed germination in Arabidopsis and lettuce .
Cat. No.: HY-164220
CAS No.: 2919466-30-9
Target:
Research Areas:
PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis .
Cat. No.: HY-19820
CAS No.: 739301-85-0
Target:
Research Areas:
NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons .
Cat. No.: HY-N8200
CAS No.: 218155-40-9
Cat. No.: HY-P76438
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ILKAP; ILKAP2; ILK Associated Serine/Threonine phosphatase; ILKAP3; Integrin-Linked Kinase-Associated Serine/Threonine phosphatase 2C; Truncated Integrin-Linked Kinase-Associated Serine/Threonine phosphatase 2C; PPM1O; Integrin-Linked Kinase-Associated Se
Species:
Human
Source:
HEK293
Cat. No.: HY-160514
CAS No.: 2097148-94-0
Target:
Research Areas:
LXQ46 is an orally active inhibitor for protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 0.190 μM. LXQ46 enhances insulin and leptin signaling pathways in insulin-resistant C2C12. LXQ46 ameliorates type 2 diabetes and increases insulin tolerance in mouse models .
Cat. No.: HY-P71022
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPM1G; protein phosphatase 1G (Formerly 2C), Magnesium-Dependent, Gamma Isoform; protein phosphatase, Mg2+/Mn2+ Dependent 1G; protein phosphatase, Mg2+/Mn2+ Dependent, 1G; protein phosphatase 1G; protein phosphatase 2C, Gamma Isoform; PP2Cgamma; protein P
Species:
Human
Source:
E. coli
Cat. No.: HY-P71227
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPM1A; protein phosphatase 1A (Formerly 2C), Magnesium-Dependent, Alpha Isoform; protein phosphatase, Mg2+/Mn2+ Dependent 1A; protein phosphatase, Mg2+/Mn2+ Dependent, 1A; protein phosphatase 1A; protein phosphatase 2C, Alpha Isoform; PP2Calpha; Alternati
Species:
Human
Source:
E. coli
Cat. No.: HY-P86320
Synonyms: PTPN11; PTP2C; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11; protein-tyrosine phosphatase 1D; PTP-1D; protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
