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Results for "

pyrazoline

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Fluorescent Dye

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145301
    Mycobactin-IN-1

    		Bacterial Infection
    Mycobactin-IN-1, a pyrazoline analogue, is a mycobactin biosynthesis inhibitor against mycobacteria. Mycobactin-IN-1 binds to salicyl-AMP ligase (MbtA), a key enzyme in the mycobactin biosynthetic pathway. Mycobactin-IN-1 inhibits whole-cell drug efflux pumps in M. smegmatis. Mycobactin-IN-1 eradicates intracellularly surviving mycobacteria. Mycobactin-IN-1 shows an excellent in vivo pharmacokinetic profile. Mycobactin-IN-1 can be used for the research of tuberculosis .
    Mycobactin-IN-1
  • HY-136376
    Mefenpyr-diethyl

    		Environmental Pollutants Herbicide Others
    Mefenpyr-diethyl is a pyrazoline-type herbicide safener that functions to enhance lipid biosynthesis. Mefenpyr-diethyl effectively prevents herbicide-induced phytotoxic damage caused by herbicides such as fenoxaprop-p-ethyl (HY-B2013) and mesosulfuron-methyl (HY-126987) by protecting cereal crops including wheat. Mefenpyr-diethyl significantly increases lipid content in wheat either when applied alone or in combination with the herbicide fenoxaprop-p-ethyl. The mechanism of action of Mefenpyr-diethyl does not involve the induction of glutathione S-transferase (GST) activity in wheat .
    Mefenpyr-diethyl
  • HY-155811
    DQP-997-74

    		iGluR Neurological Disease
    DQP-997-74 (compound 2i) is a selective negative allosteric modulator of N-methyl-d-aspartate receptor (NMDAR), specifically targeting GluN2C/D (IC50: 0.069 μM and 0.035 μM), with blood-brain barrier penetrability. Where DQP refers to dihydroquinoline-pyrazoline. DQP-997-74 acts synergistically with the agonist glutamate to exhibit time-dependent enhanced potency in inhibiting hypersynchronous activity driven by high-frequency excitatory synaptic transmission. DQP-997-74 reduces the number of epileptogenesis in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 can be used for research on NMDAR-related neurological diseases .
    DQP-997-74
  • HY-143293
    VEGFR-IN-3

    		VEGFR Apoptosis Cancer
    VEGFR-IN-3 (compound 3f) is a VEGFR inhibitor. VEGFR-IN-3 inhibits OVCAR-4 and MDA-MB-468 cancer cells growth with IC50s of 0.29 and 0.35 μM, respectively. VEGFR-IN-3 can be used for the research of cancer .
    VEGFR-IN-3
  • HY-W023983
    Chalcone dibromide

    		Drug Derivative Cancer
    Chalcone dibromide is a useful synthon in the synthesis of a large number of bioactive molecules such as pyrazolines, hydroxy pyrazolines, isoxazoles etc. Chalcone dibromide possesses antioxidant effects against tumor cells by inhibiting superoxide production and lipid peroxidation. Chalcone dibromide can be used for cancer disease research .
    Chalcone dibromide
  • HY-W269270
    1,3,5-Triphenyl-2-pyrazoline

    		Drug Derivative Cancer
    1,3,5-Triphenyl-2-pyrazoline (Compound 12) is a pyrazoline derivative. 1,3,5-Triphenyl-2-pyrazoline exhibits weak cytotoxicity against K562 and Jurkat cells, with an IC50 of greater than 300 μM and 297.7 μM, respectively. 1,3,5-Triphenyl-2-pyrazoline has a predicted human intestinal absorption rate of 100% .
    1,3,5-Triphenyl-2-pyrazoline
  • HY-172156
    EGFR-TK-IN-5

    		EGFR Cancer
    EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl-pyrazoline derivative. EGFR-TK-IN-5 exhibits strong inhibitory activity and stability against EGFR. EGFR-TK-IN-5 can be used in the study of cancer .
    EGFR-TK-IN-5
  • HY-162575
    Anticancer agent 231

    		ERK Cancer
    Anticancer agent 231 (Compound P5) is a tyrosine protein kinase inhibitor with a IC50 value of 3.95 μM. Anticancer agent 231 inhibits the cell viability, cell proliferation, cell migration and cancer dryness of triple negative breast cancer (TNBC) cells by targeting EGFR-ERK 1/2 signaling pathway, and is expected to play an important role in the field of TNBC disease therapy .
    Anticancer agent 231
  • HY-179031
    EGFR/VEGFR2-IN-7

    		EGFR VEGFR Apoptosis Cancer
    EGFR/VEGFR2-IN-7 (Compound 3e) is a dual-target EGFR/VEGFR2 inhibitor, with IC50 values of 142 (EGFR) and 71 nM (VEGFR2). EGFR/VEGFR2-IN-7 exhibits broad-spectrum and potent anti-proliferative activity, especially being sensitive to breast cancer. EGFR/VEGFR2-IN-7 induces cell cycle arrest and apoptosis, inhibits cell migration and invasion. EGFR/VEGFR2-IN-7 can be used for research on breast cancer .
    EGFR/VEGFR2-IN-7

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