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Results for "

rat heart receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (3) Adrenergic Receptor (5) Akt (1) Antibiotic (1) Apelin Receptor (APJ) (2) Apoptosis (5) Arrestin (1) Bacterial (1) Carbonic Anhydrase (1) Cholinesterase (ChE) (1) Cytochrome P450 (1) Endothelin Receptor (1) Formyl Peptide Receptor (FPR) (1) GABA Receptor (1) Insulin Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (1) mAChR (4) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (1) N-myristoyltransferase (1) Natriuretic Peptide Receptor (NPR) (1) Neuropeptide Y Receptor (2) PKA (1) Protease Activated Receptor (PAR) (4) Reactive Oxygen Species (ROS) (1) Reference Standards (3)
By Research Areas:	Cancer (2) Cardiovascular Disease (24) Infection (1) Inflammation/Immunology (1) Metabolic Disease (4) Neurological Disease (3)

By Targets:

Adenosine Receptor (3)

Adrenergic Receptor (5)

Akt (1)

Antibiotic (1)

Apelin Receptor (APJ) (2)

Apoptosis (5)

Arrestin (1)

Bacterial (1)

Carbonic Anhydrase (1)

Cholinesterase (ChE) (1)

Cytochrome P450 (1)

Endothelin Receptor (1)

Formyl Peptide Receptor (FPR) (1)

GABA Receptor (1)

Insulin Receptor (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

mAChR (4)

Mineralocorticoid Receptor (1)

Mitochondrial Metabolism (1)

N-myristoyltransferase (1)

Natriuretic Peptide Receptor (NPR) (1)

Neuropeptide Y Receptor (2)

PKA (1)

Protease Activated Receptor (PAR) (4)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

By Research Areas:

Cancer (2)

Cardiovascular Disease (24)

Infection (1)

Inflammation/Immunology (1)

Metabolic Disease (4)

Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14993

SCH79797 5 Publications Verification	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
SCH79797 is a highly potent, selective nonpeptide *protease activated receptor* 1 (PAR1)** antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC₅₀ of 70 nM and a K_i of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC₅₀ of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .

HY-101381

Otenzepad 2 Publications Verification AF-DX 116	mAChR	Neurological Disease Metabolic Disease
Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC₅₀ values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively .

HY-14994

SCH79797 dihydrochloride 5 Publications Verification	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
SCH79797 dihydrochloride is a highly potent, selective nonpeptide *protease activated receptor* 1 (PAR1)** antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC₅₀ of 70 nM and a K_i of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC₅₀ of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .

HY-B1486

Oxprenolol hydrochloride 1 Publications Verification Ba 39089	Adrenergic Receptor	Cardiovascular Disease
Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-N0597

Panaxatriol 3 Publications Verification	Akt Insulin Receptor Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Cancer
Panaxatriol is an orally active dammarane-type tetracyclic triterpene sapogenin. Panaxatriol enhances the phosphorylation levels of Akt, insulin receptor and p70S6K in skeletal muscle. Panaxatriol reduces the mRNA expression level of Atrogin1 in skeletal muscle. Panaxatriol induces apoptosis, pre-G1 cell cycle arrest and increased intracellular ROS levels in prostate cancer cells, decreases mitochondrial membrane potential, inhibits cell migration and reduces colony formation. Panaxatriol can be used in research related to insulin resistance, myocardial ischemia/reperfusion injury and prostate cancer ^[1][2][3].

HY-B1486AS

Oxprenolol-d7	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Oxprenolol-d₇ is the deuterium labeled Oxprenolol. Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-B1277A

Trihexyphenidyl	mAChR Cholinesterase (ChE)	Cardiovascular Disease Neurological Disease
Trihexyphenidyl is a selective and orally active M₁ muscarinic receptor antagonist with an IC₅₀ of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl can be used for the research of Parkinson's disease. .

HY-P3678

Neuropeptide Y (18-36) (porcine)	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC₅₀ value of 158 nM and an K_i value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure .

HY-160076

APJ receptor agonist 8	Apelin Receptor (APJ)	Cardiovascular Disease
APJ receptor agonist 8 (compound 99) is an agonist of APJ receptor. APJ receptor agonist 8 increases the load independent cardiac contractility of isolated perfused rat hearts .

HY-B1486A

Oxprenolol Ba 39089 free base	Adrenergic Receptor	Cardiovascular Disease
Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-105362

PD 155080	Endothelin Receptor	Cardiovascular Disease
PD 155080 is a selective endothelin A receptor (ET_A receptor) antagonist. PD 155080 reduces coronary resistance in the isolated rat heart model. PD 155080 improves myocardial systolic function and diastolic function in the ischemia/reperfusion model. PD 155080 can be used for the study of cardiovascular diseases .

HY-133036

APJ receptor agonist 1	Apelin Receptor (APJ)	Cardiovascular Disease
APJ receptor agonist 1, a biphenyl acid derivative, is a potent *APJ receptor* (APJ-R) agonist (EC₅₀*s 0.093 and 0.12 nM for human and rat* APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure .

HY-B1486S

Oxprenolol-d7 hydrochloride Ba 39089-d₇	Adrenergic Receptor	Cardiovascular Disease
Oxprenolol-d₇ (hydrochloride) is the deuterium labeled Oxprenolol hydrochloride. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-120321

DSR-71167	Mineralocorticoid Receptor Carbonic Anhydrase	Cardiovascular Disease
DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC₅₀ of 0.26 μM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC₅₀ of 19 μM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure .

HY-14993R

SCH79797 (Standard)	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
SCH79797 (Standard) is the analytical standard of SCH79797. This product is intended for research and analytical applications. SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .

HY-19240

Naxifylline BG9719; CVT-124	Adenosine Receptor	Cardiovascular Disease
Naxifylline (BG9719; CVT-124) is a potent and selective A1-adenosine antagonist with K_i values of 0.67 and 0.45 nM for rat and cloned human A1-receptors, respectively. Naxifylline is a potassium-sparing diuretic for the study of edema associated with congestive heart failure .

HY-W008226R

Phloracetophenone (Standard) 2,4,6-trihydroxyacetophenone (Standard); 1-(2,4,6-Trihydroxyphenyl)ethanone (Standard)	Reference Standards Cytochrome P450 Bacterial Antibiotic	Infection Metabolic Disease
Oxprenolol (hydrochloride) (Standard) is the analytical standard of Oxprenolol (hydrochloride). This product is intended for research and analytical applications. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-B1486R

Oxprenolol hydrochloride (Standard) Ba 39089 (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Oxprenolol (hydrochloride) (Standard) is the analytical standard of Oxprenolol (hydrochloride). This product is intended for research and analytical applications. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-171467

MRS7799 DPTN	Adenosine Receptor	Inflammation/Immunology Cancer
MRS7799 is a selective A 3 Adenosine Receptor antagonist agsinst human, mouse, and rat A3AR with K_ds of 0.55, 3.74 and 2.80 nM, respectively. MRS7799 can be used in the study of neurodegeneration, cancer, ischemia of the heart and brain, autoimmune inflammatory diseases .

HY-19310

AMP-579	Adenosine Receptor	Cardiovascular Disease Metabolic Disease
AMP-579 is an adenosine receptor agonist that primarily targets adenosine A1 and A2_A receptors (with K_i values of 1.7 and 4.5 nM for the A1 receptor in rat brain and adipocytes, and a K_i value of 56 nM for the A2_A receptor in rat brain). AMP-579 inhibits lipolysis, restores insulin-dependent glucose transport, and reduces heart rate through the activation of A1 receptors, while it induces vasodilation, particularly in coronary arteries, through the activation of A2_A receptors (with an IC₅₀ of 0.3 μM in porcine coronary arterial rings). AMP 579 shows potential for application in cardioprotection and the treatment of acute myocardial infarction .

HY-P1428A

RFRP-1(human) TFA	Neuropeptide Y Receptor	Cardiovascular Disease
RFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC₅₀ values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.

HY-136625

LY134046	N-myristoyltransferase	Cardiovascular Disease
LY134046 is an inhibitor of norepinephrine N-methyltransferase (NMT) with cardiovascular activity. LY134046 causes sustained reductions in mean arterial blood pressure and heart rate, but no significant reductions in norepinephrine concentrations in the rat brain. LY134046 does not interact with adrenergic or cholinergic receptors, and its hypotensive and bradycardic effects do not require neurogenic tension. LY134046 (40 mg/kg/day) causes sustained and significant inhibition of hypothalamic and brainstem NMT activity, resulting in central norepinephrine depletion.

HY-14994R

SCH79797 dihydrochloride (Standard)	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
SCH79797 (dihydrochloride) (Standard) is the analytical standard of SCH79797 (dihydrochloride). This product is intended for research and analytical applications. SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .

HY-N0597R

Panaxatriol (Standard)	Reference Standards Others	Others
Panaxatriol (Standard) is the analytical standard of Panaxatriol. This product is intended for research and analytical applications. Panaxatriol is an orally active dammarane-type tetracyclic triterpene sapogenin. Panaxatriol enhances the phosphorylation levels of Akt, insulin receptor and p70S6K in skeletal muscle. Panaxatriol reduces the mRNA expression level of Atrogin1 in skeletal muscle. Panaxatriol induces apoptosis, pre-G1 cell cycle arrest and increased intracellular ROS levels in prostate cancer cells, decreases mitochondrial membrane potential, inhibits cell migration and reduces colony formation. Panaxatriol can be used in research related to insulin resistance, myocardial ischemia/reperfusion injury and prostate cancer .

HY-186083

Propylbenzilylcholine mustard	mAChR	Cardiovascular Disease
Propylbenzilylcholine mustard (PrBCM) is an irreversible, covalently binding selective antagonist targeting rat cardiac muscarinic receptors, with a preference for muscarinic receptor subtypes that show low affinity for agonists. Propylbenzilylcholine mustard inactivates such receptors in a dose- and time-dependent manner in vitro, and its receptor selectivity remains stable across different ionic strengths and in GTP-containing buffer systems. Propylbenzilylcholine mustard can be applied to basic pharmacological studies on the structure and function of muscarinic receptors, especially focusing on the heterogeneity of cardiac muscarinic receptors and related cardiovascular pharmacological research .

HY-126862

AQ-RA 721	mAChR	Others
AQ-RA 721 is a muscarinic receptor antagonist with differential affinity for the m4 and M2 sites, which can be used to characterize muscarinic receptor subtypes. Other muscarinic receptor antagonists have differential affinity for the M1 (rat cerebral cortex), M2 (rat heart), M3 (rat submandibular gland), m4 (receptor expressed in Chinese hamster ovary cells transfected with CHO), and guinea pig uterine smooth muscle at the muscarinic binding site .

HY-W436366

SSR180575	GABA Receptor Mitochondrial Metabolism	Cardiovascular Disease
SSR180575 is a specific and potent peripheral benzodiazepine receptor ligand. SSR180575 irreversibly and specifically binds with high affinity on rat heart mitochondria (K_d = 1.95 nM). SSR180575 can be used in the research of cardiovascular diseases .

HY-181822

BMS-986331	Formyl Peptide Receptor (FPR) Arrestin PKA Interleukin Related	Cardiovascular Disease
BMS-986331 is an orally active selective *N-Formyl Peptide Receptor* 2 (FPR2) agonist with an EC₅₀ of 0.5 nM in humans and 1 nM in rats. BMS-986331 activates Gαi2, GαoA, Gα12, Gα13 signaling pathways, recruits β-arrestin1 and β-arrestin2, and inhibits downstream cAMP. BMS-986331 induces the expression and release of the pro-resolution cytokine IL-10*. BMS-986331 improves cardiac structure and function in a rat* model of heart failure induced by permanent coronary artery occlusion. BMS-986331 can be used for the research of heart failure .

HY-W092067

6-Hydroxyisatin	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
6-Hydroxyisatin is an atrial natriuretic peptide receptor (ANP receptor) inhibitor. 6-Hydroxyisatin exhibits inhibitory activity against ANP-stimulated particulate guanylyl cyclase activity in rat brain cell membranes .

Cat. No.	Product Name	Target	Research Area