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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
rat paw edema
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "rat paw edema" in MCE Product Catalog:
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1 Cited Publications
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Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
PSB36 is a highly selective A1 adenosine receptor antagonist, with a Ki of 0.12 nM and a Kd of 0.7 nM. Systemic administration of PSB36 reduces formalin- and Carrageenan (HY-125474)-induced edema in mice and decreases pain-related behaviors, with no local paw activity. PSB36 prolongs the APD90 of rat and human atria, produces a frequency-dependent prolongation of rat atrial ERP, increases the diastolic threshold of rat atria, and shortens the duration of atrial fibrillation episodes. PSB36 can be used in research related to inflammatory pain, inflammatory hyperalgesia, edema and atrial fibrillation .
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Cat. No.: HY-W021267
CAS No.: 7336-33-6
Category:
Alkaloids other families Monophenols Other Alkaloids Phenols Plants Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-134521
CAS No.: 15362-40-0
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Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) .
Cat. No.: HY-124517
CAS No.: 34970-69-9
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Burimamide is a blocker of histamine H2-receptor. Burimamide inhibits gastric acid secretion evoked by Pentagastrin (HY-A0261) or Gastrin. Burimamide also has alpha-adrenoceptor blocking activity. Burimamide in combination with the H1-receptor antagonist Mepyramine (HY-B1281) shows anti-inflammatory activity in a rat paw edema model induced by Compound 48/80 (HY-115768) .
Cat. No.: HY-119298
CAS No.: 905285-51-0
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AW-814141 is a selective and orally active p38 MAP kinase inhibitor. AW-814141 has an IC50 values of 100 nM and 158 nM for p38-α and β isoforms, respectively. AW-814141 can inhibit the production of TNF-α induced by LPS (HY-D1056). AW-814141 can inhibit paw edema in rats in a dose-dependent manner. AW-814141 exhibits anti-inflammatory activity and can be used in the research of inflammatory diseases such as rheumatoid arthritis .
Cat. No.: HY-116873
CAS No.: 66934-18-7
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Flunoxaprofen is an orally active COX inhibitor. Flunoxaprofen shows anti-inflammatory activity in a rat paw edema model. Flunoxaprofen may be used in research on immune system diseases such as arthritis .
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COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects .
Cat. No.: HY-119279
CAS No.: 848837-33-2
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VUF 10214 is a H4 receptor ligand with a pKi of 8.25. VUF 10214 exhibits significant anti-inflammatory activity in a carrageenan-induced paw edema rat model and can be used for research in the field of inflammatory diseases .
Cat. No.: HY-134996
CAS No.: 849067-18-1
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N-Acetyl-2-carboxybenzenesulfonamide is an orally active COX-1 and COX-2 inhibitor with IC50s of 0.06 μM and 0.25 μM, respectively. N-Acetyl-2-carboxybenzenesulfonamide shows anti-inflammatory activity .
Cat. No.: HY-N8458
CAS No.: 10308-13-1
Synonyms: NSC 272693
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Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.
Cat. No.: HY-147719
CAS No.: 1610894-92-2
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COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity .
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Cat. No.: HY-129143R
CAS No.: 53158-73-9
Synonyms: Dp3‐Sam chloride (Standard)
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Cat. No.: HY-162166
CAS No.: 3027770-84-6
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COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC50 values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments .
Cat. No.: HY-W747879
Cat. No.: HY-149270
CAS No.: 3039955-76-2
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COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX(Ki=48.9 nM) and hCA XII(Ki=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity .
Cat. No.: HY-183447
CAS No.: 101311-04-0
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Cat. No.: HY-179700
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COX-2-IN-61 is an orally active COX-2 inhibitor with an IC50 of 22 µM, also inhibits COX-1 with an IC50 of 43 µM. COX-2-IN-61 exhibits anti-inflammation effects in a Carrageenan (HY-125474) induced rat paw edema model, with promising safety profiles. COX-2-IN-61 can be used for the research of inflammation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
