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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
sinusoidal
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "sinusoidal" in MCE Product Catalog:
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Defibrotide (sodium)
Cat. No.: HY-108746
CAS No.: 83712-60-1
Cat. No.: HY-125864C
CAS No.: 9001-32-5
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Porcine Fibrinogen is a coagulation protein, purified from porcine plasma with no plasminogen contained. Porcine Fibrinogen has excellent biocompatibility and does not induce aggregation of porcine platelets when in contact with porcine hepatocytes, aortic endothelial cells or hepatic sinusoidal endothelial cells. Porcine Fibrinogen is widely used in studies on the pathological mechanisms of cardiovascular diseases such as atherosclerosis and the development of related drugs .
Cat. No.: HY-173564
CAS No.: 2758171-54-7
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DW34 is an orally active pan-BRD4-D1 biased inhibitor with additional BRD4-D2 inhibitive activity. DW34 displays comparable inhibitive efficacy to I-BET151 (HY-13235) (EC50 = 0.16 μM) with low nanomolar EC50 values of 0.14 μM. DW34 significantly reduces liver inflammation induced by LPS (HY-D1056) and APAP (HY-66005) via reducing chemokine expression and cellular necrosis .
Cat. No.: HY-W762019
CAS No.: 39227-28-6
Synonyms: 1,2,3,4,7,8-HxCDD
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1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin is a polychlorinated dibenzo-p-dioxin (PCDD) congener. 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin can cause pale (fatty) livers, gastrointestinal hemorrhage and early death in H/W and line A rats at the highest dose (10,000 μg/kg). 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin also induces sinusoidal distension, and even severe peliosis in line B .
Cat. No.: HY-19586
CAS No.: 107767-55-5
Synonyms: A 81-3138; HWA-138
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Albifylline (A 81-3138; HWA-138) is a Xanthine (HY-W017389) derivate. Albifylline reduces the shock-induced leukocyte adhesions to the sinusoidal endothelium in the liver after hemorrhagic shock and improves microvascular blood flow in the liver .
Cat. No.: HY-P992461
Cat. No.: HY-184378
CAS No.: 2922221-22-3
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MDB5 is a Hedgehog pathway and Smoothened inhibitor that binds to the 7-TM domain of Smo . MDB5 reduces hepatic stellate cell activation, extracellular matrix-related gene expression, collagen deposition, hydroxyproline content and epithelial-mesenchymal transition, and prevents sinusoidal endothelial cell capillarization . MDB5 induces G1 and S phase cell cycle arrest, triggers apoptosis by upregulating Bax and downregulating Bcl-2, and also decreases oxygen consumption rate, glucose uptake, transglutaminase activity and fibronectin matrix assembly . MDB5 reduces the levels of liver injury markers, hepatic triglyceride deposition and hepatic steatosis, restores the tissue structure of the kidney and spleen, and inhibits pancreatic tumor growth without causing body weight loss . MDB5 can be loaded into PEG-PCC-g-DC micelles, achieving high drug loading, sustained release, improved water solubility, enhanced cellular uptake and optimized hepatic distribution, with good tolerance in mice . MDB5 is applicable to research related to alcohol-associated liver disease, liver fibrosis and pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
