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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
296 Results for "
skeletal muscle
" in MedChemExpress (MCE) Product Catalog:
Products (296)
296 Results for "skeletal muscle" in MCE Product Catalog:
76
72
Target:
Research Areas:
Metronidazole hydrochloride (SC 326421) is an orally active nitroimidazole antibiotic, can be used to research anaerobic infections. Metronidazole hydrochloride can cross blood brain barrier and results inflammation and skeletal muscle contraction under long-term application .
36
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C188-9 (TTI-101) is a STAT3 inhibitor with a Kd value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .
22
22 Cited Publications
Cat. No.: HY-W011012
CAS No.: 4578-31-8
11
11 Cited Publications
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Research Areas:
CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation .
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11 Cited Publications
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Research Areas:
CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation .
9
9 Cited Publications
Synonyms: 5'-GTP trisodium salt hydrate
9
Target:
6
6 Cited Publications
Synonyms: 5'-GTP trisodium
6
Category:
Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology
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5
Category:
Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite
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5
5 Cited Publications
Cat. No.: HY-W011393
CAS No.: 10030-52-1
Target:
3
3 Cited Publications
Synonyms: N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC50s of ~5 µM for actin- and Ca 2+-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .
3
3 Cited Publications
Cat. No.: HY-D0885A
CAS No.: 71519-72-7
Synonyms: Creatine phosphate disodium tetrahydrate; Creatinephosphoric acid disodium tetrahydrate
Target:
3
3 Cited Publications
Cat. No.: HY-N0597
CAS No.: 32791-84-7
3
3 Cited Publications
Cat. No.: HY-P0222
CAS No.: 99534-03-9
3
3 Cited Publications
Synonyms: Creatine phosphate; Creatinephosphoric acid
3
3
3 Cited Publications
Cat. No.: HY-D0885D
CAS No.: 19333-65-4
3
Category:
Citrus × aurantium Linnaeus Rutaceae Plants Endogenous metabolite Alkaloids Monophenols Other Alkaloids Other Diseases Phenols Disease Research Fields
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
