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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
spinocerebellar
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "spinocerebellar" in MCE Product Catalog:
2
Target:
Research Areas:
Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA) .
Synonyms: NCD
Target:
Research Areas:
Naphthyridine carbamate dimer (NCD) is a molecular glue. Naphthyridine carbamate dimer induces designed structural changes in target functional DNA, thereby regulating its function. As a molecular glue, naphthyridine carbamate dimer stabilizes non-spontaneously formed GG homologous mismatched double-stranded DNA. Naphthyridine carbamate dimer reduces the formation of toxic RNA foci and regulates CGG repeat instability associated with fragile X syndrome and spinocerebellar ataxia type 31. Naphthyridine carbamate dimer can be used in research related to fragile X syndrome and spinocerebellar ataxia type 31 .
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NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias .
Synonyms: ASC-JM17; ALZ-003
Target:
Keap1-Nrf2 Androgen Receptor HSP Mitophagy Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Autophagy
Research Areas:
Rosolutamide (ASC-JM17) is an orally active Nrf1/Nrf2 activator. Rosolutamide activates Hsf1 pathways, upregulates proteasome subunits and antioxidant enzymes, induces proteasome complex structural rearrangement, and enhances ubiquitin-proteasome system-mediated degradation. Rosolutamide reduces mutant androgen receptor and ataxin-3 aggregates, restores mitochondrial function, attenuates reactive oxygen species (ROS) levels, induces apoptosis and ferroptosis, and inhibits cancer cell growth. Rosolutamide can be used for the research of spinal and bulbar muscular atrophy, Huntington’s disease, and temozolomide-resistant glioblastoma .
Cat. No.: HY-163171
CAS No.: 1214569-31-9
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ARN 11391 is a selective enhancer of inositol triphosphate receptor type 1 (ITPR1). ARN 11391 can be used in the study of spinocerebellar ataxia .
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TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM .
Cat. No.: HY-160884
CAS No.: 1470023-72-3
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DMT-2'-OMe-D-Ribitol phosphoramidite is a phosphoramidite monomer synthesized from (2R,3S,4S)-2-hydroxymethyl-4-methoxytetrahydrofuran-3-ol, used to introduce the Y34 abasic moiety into oligonucleotides for solid-phase oligonucleotide synthesis. DMT-2'-OMe-D-Ribitol phosphoramidite can be used for the research of huntington's disease, machado joseph disease (spinocerebellar ataxia 3) .
Cat. No.: HY-E70871
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TTBK2 is a tau tubulin kinase. Mutations in TTBK2 cause spinocerebellar ataxia type 11, a disorder exhibiting both loss of Purkinje cells and widespread deposition of tau. TTBK2 Recombinant Human Active Protein Kinase is a recombinant TTBK2 protein that can be used to study TTBK2-related functions .
Cat. No.: HY-172544
CAS No.: 2857982-34-2
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TTBK1/2-IN-3 (Compound 10) is a potent inhibitor of tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 inhibits the phosphorylation of TDP-43. TTBK1/2-IN-3 reduces the expression of primary cilia on the surface of iPSCs .
Cat. No.: HY-118117
CAS No.: 204386-76-5
Synonyms: S0373
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Rovatirelin is an orally active thyrotropin-releasing hormone (TRH) analog. Rovatirelin binds to the human TRH receptor with a Ki value of 702 nM. Rovatirelin can be used to study spinocerebellar degeneration (SCD) .
Cat. No.: HY-173353
CAS No.: 420106-23-6
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ATXN1-MED15 PPI-IN-1 (compound 5755483) is an inhibitor of ATXN1/MED15. ATXN1-MED15 PPI-IN-1 binds to ATXN1 residues 99-163 and inhibits both the interaction between ATXN1 and MED15, as well as the dimerization of polyQ-expanded ATXN1. ATXN1-MED15 PPI-IN-1 can be used for study of Spinocerebellar ataxia type 1 .
Cat. No.: HY-142723
CAS No.: 1019106-73-0
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KCa2 channel modulator 1 (compound 2o) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 1 potentiates human KCa2.3 channels with an EC50 value of 0.19 μM and 0.99 μM on the rat KCa2.2 channel subtype .
Cat. No.: HY-142735
CAS No.: 2764618-34-8
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KCa2 channel modulator 2 (compound 2q) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 2 exhibits similar potency on the rat KCa2.2a and human KCa2.3 channel subtypes, with EC50s of 0.64 μM and 0.60 μM, respectively
Research Areas:
LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research .
Cat. No.: HY-109160R
CAS No.: 2167246-24-2
Synonyms: CAD-1883 (Standard)
Target:
Research Areas:
Rimtuzalcap (Standard) is the analytical standard of Rimtuzalcap (HY-109160). This product is intended for research and analytical applications. Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA) .
Cat. No.: HY-P71058
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDYN; Neoendorphin-Dynorphin-Enkephalin Prepropeptide; Prev. SCA23; Leu-Enkephalin; Beta-Neoendorphin-Dynorphin; Leumorphin; Proenkephalin-B; Rimorphin; Preprodynorphin; spinocerebellar Ataxia 23; PENKB; Beta-Neoendorphin; ADCA; Dynorphin; Prodynorphin; P
Species:
Human
Source:
HEK293
Cat. No.: HY-P70980
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TPP1; Tripeptidyl Peptidase I; Prev. CLN2; Ceroid-Lipofuscinosis, Neuronal 2, Late Infantile (Jansky-Bielschowsky Disease); Prev. SCAR7; spinocerebellar Ataxia, Autosomal Recessive 7; TPP-1; Lysosomal Pepstatin Insensitive Protease; LPIC; Lysosomal Pepsta
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
