27 Results for "

vascular cell adhesion molecule-1

" in MedChemExpress (MCE) Product Catalog:
Products (27)

27 Results for "vascular cell adhesion molecule-1" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-N1990
CAS No.: 94987-08-3
Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a Ka value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .
loading...
    loading...
Cat. No.: HY-N2110
CAS No.: 2543-94-4
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .
loading...
    loading...
Cat. No.: HY-N2110R
CAS No.: 2543-94-4
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.
loading...
    loading...
Cat. No.: HY-127113
CAS No.: 1541762-55-3
Target:  

Leukotriene Receptor

Research Areas:  

Cardiovascular Disease

Q8, an effective antiangiogenic drug, is a CysLt1 antagonist (IC50 of 4.9 μM). Q8 is sufficient to reduce cellular levels of NF-κB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF .
loading...
    loading...
Cat. No.: HY-N1990R
CAS No.: 94987-08-3
Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .
loading...
    loading...
Cat. No.: HY-W027751R
CAS No.: 578-58-5
Research Areas:  

Others

Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .
loading...
    loading...
Cat. No.: HY-119142
CAS No.: 379692-00-9
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

CP-664511 is an orally active and potent α4β1 integrin antagonist with anti-inflammatory effects (IC50=0.52 nM). CP-664511 inhibits the interaction between α4β1 and vascular cell adhesion molecule-1 (VCAM-1), significantly reducing eosinophil infiltration into lung tissue. CP-664511 is promising for research of asthma and allergic airway diseases .
loading...
    loading...
Cat. No.: HY-P70852
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin cell adhesion molecule 1; Mucosal Addressin cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P77748
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin cell adhesion molecule 1; Mucosal Addressin cell adhesion molecule-1; MACAM1
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P704773
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin cell adhesion molecule 1; Mucosal Addressin cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P71818
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin cell adhesion molecule 1; Mucosal Addressin cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
P. pastoris
loading...
    loading...
Cat. No.: HY-P72397
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin cell adhesion molecule 1; Mucosal Addressin cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P704774
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin cell adhesion molecule 1; Mucosal Addressin cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P705058
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin cell adhesion molecule 1; Mucosal Addressin cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P705198
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin cell adhesion molecule 1; Mucosal Addressin cell adhesion molecule-1; MACAM1
Species:  
Cynomolgus
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P705263
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin cell adhesion molecule 1; Mucosal Addressin cell adhesion molecule-1; MACAM1
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P72432
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VCAM1; vascular cell adhesion molecule 1; vascular cell adhesion Protein 1; CD106; CD106 Antigen; INCAM-100; V-CAM 1; VCAM-1
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P73469
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VCAM1; vascular cell adhesion molecule 1; vascular cell adhesion Protein 1; CD106; CD106 Antigen; INCAM-100; V-CAM 1; VCAM-1
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P73468
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VCAM1; vascular cell adhesion molecule 1; vascular cell adhesion Protein 1; CD106; CD106 Antigen; INCAM-100; V-CAM 1; VCAM-1
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P73470
Purity:  ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: VCAM1; vascular cell adhesion molecule 1; vascular cell adhesion Protein 1; CD106; CD106 Antigen; INCAM-100; V-CAM 1; VCAM-1
Species:  
Mouse
Source:  
HEK293
loading...
    loading...