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Results for "

ventricular dysfunction

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

1

Peptides

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129029
    Bisoprolol
    Maximum Cited Publications
    6 Publications Verification

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Cancer
    Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
    Bisoprolol
  • HY-B0076
    Bisoprolol hemifumarate
    Maximum Cited Publications
    6 Publications Verification

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    Bisoprolol hemifumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol hemifumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
    Bisoprolol hemifumarate
  • HY-174374
    Topobexin

    		Topoisomerase Cardiovascular Disease
    Topobexin is a TOP2B-selective inhibitor with IC50 values of 0.19 μM and 4.8 μM for TOP2B and TOP2A (DNA decatenation assay). Topobexin binds to non-homologous residues in the obex pocket and targets the ATPase domain of TOP2B. Topobexin prevents anthracycline-induced DNA double-strand break formation, apoptotic signaling mediated by caspase 3/7, 8 and 9, cardiomyocyte morphological changes, mitochondrial depolarization/loss, left ventricular systolic dysfunction, extracellular matrix remodeling, fibrotic alterations, and increases in plasma cardiac troponin T and BNP. Topobexin does not impair the antiproliferative effects of anthracyclines in cancer cells, exhibits no intrinsic cytotoxicity in cardiomyocytes, and is well tolerated in rabbits. Topobexin can be used in studies related to anthracycline-induced cardiotoxicity .
    Topobexin
  • HY-106844A
    (+)-EMD 57033

    		Phosphodiesterase (PDE) Cardiovascular Disease
    (+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca 2+ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function .
    (+)-EMD 57033
  • HY-107428
    PD-166793

    		MMP Cardiovascular Disease
    PD-166793 is a potent, selective, orally active and wide-broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC50=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure .
    PD-166793
  • HY-161119
    Drpitor1a

    		Dynamin Reactive Oxygen Species (ROS) Cardiovascular Disease Cancer
    Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer [1]
    Drpitor1a
  • HY-P5904
    Caveolin-1 (82-101) amide (human, mouse, rat)

    Caveolin-1 scaffolding domain peptide

    		 c-Met/HGFR Others
    Caveolin-1 (82-101) amide (human, mouse, rat) (Caveolin-1 scaffolding domain peptide) is a peptide that reverses aging-associated deleterious changes in multiple organs. Caveolin-1 (82-101) amide (human, mouse, rat) inhibits tyrosine kinases .
    Caveolin-1 (82-101) amide (human, mouse, rat)
  • HY-172424
    Delocamten

    		Myosin Cardiovascular Disease
    Delocamten is the inhibitor for cardiac myosin with an IC50 of 1.1 μM. Delocamten can be used in researchs of hypertrophic cardiomyopathy, left ventricular hypertrophy and diastolic dysfunction .
    Delocamten
  • HY-173517
    NHE-1-IN-2

    		Na+/H+ Exchanger (NHE) Neurological Disease
    NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. NHE-1-IN-2 alleviates left ventricular systolic dysfunction in mice model of heart failure .
    NHE-1-IN-2
  • HY-129029S
    Bisoprolol-d5

    		Isotope-Labeled Compounds Adrenergic Receptor Cardiovascular Disease
    Bisoprolol-d5 is the deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
    Bisoprolol-d5
  • HY-120829
    Bisoprolol fumarate

    		Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Cancer
    Bisoprolol fumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol fumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
    Bisoprolol fumarate
  • HY-139727A
    S(-)-Bisoprolol fumarate

    		Adrenergic Receptor Cardiovascular Disease
    S(-)-Bisoprolol fumarate is a S(-)-enantiomer of Bisoprolol fumarate. Bisoprolol fumarate is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
    S(-)-Bisoprolol fumarate
  • HY-139727
    S(-)-Bisoprolol

    		Adrenergic Receptor Cardiovascular Disease
    S(-)-Bisoprolol is a S(-)-enantiomer of Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
    S(-)-Bisoprolol
  • HY-120355
    AP14145

    		Potassium Channel Cardiovascular Disease
    AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa channel with IC50 of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect .
    AP14145
  • HY-121306
    Indecainide

    Ricainide; LY 135837 free base

    		 Sodium Channel Neurological Disease
    Indecainide (Ricainide) is an orally active antiarrhythmic agent. Indecainide can be used in the research of ventricular dysfunction. Indecainide has Na +-channel-blocking activity .
    Indecainide
  • HY-129029R
    Bisoprolol (Standard)

    		Reference Standards Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Cancer
    Bisoprolol (Standard) is the analytical standard of Bisoprolol. This product is intended for research and analytical applications. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
    Bisoprolol (Standard)
  • HY-158186S
    Bisoprolol-d6 hemifumarate

    		Isotope-Labeled Compounds Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    Bisoprolol-d6 fumarate is deuterium labeled Bisoprolol (hemifumarate). Bisoprolol hemifumarate is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol hemifumarate has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
    Bisoprolol-d6 hemifumarate
  • HY-120257
    IDN-1965

    		Caspase Apoptosis Cardiovascular Disease
    IDN-1965 is an irreversible, broad-spectrum caspase inhibitor. IDN-1965 prevents downstream apoptotic events (such as DNase activation) and significantly delays cytochrome c release by inhibiting caspase activity. IDN-1965 significantly delayed death in mice with cardiomyocyte apoptosis. IDN-1965 completely prevents left ventricular dilation, systolic dysfunction, and fibrosis in mice with dilated cardiomyopathy. IDN-1965 can be used to study apoptosis-related diseases such as heart failure and the mechanisms of apoptosis initiation .
    IDN-1965
  • HY-107428R
    PD-166793 (Standard)

    		Reference Standards MMP Cardiovascular Disease
    PD-166793 (Standard) is the analytical standard of PD-166793 (HY-107428). This product is intended for research and analytical applications. PD-166793 is a potent, selective, orally active and wide-broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC50=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure .
    PD-166793 (Standard)
  • HY-W707407
    Bisoprolol-d7

    		Isotope-Labeled Compounds Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Cancer
    Bisoprolol-d7 is deuterium labeled Bisoprolol. Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker with little activity on β2-receptor. Bisoprolol has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research .
    Bisoprolol-d7

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