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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
36 Results for "
viral fusion protein
" in MedChemExpress (MCE) Product Catalog:
Products (36)
36 Results for "viral fusion protein" in MCE Product Catalog:
21
21 Cited Publications
Cat. No.: HY-U00434
CAS No.: 890405-51-3
Research Areas:
3BDO is a IFITM3 modulator and mTOR activator with antiviral and autophagy-inhibiting effects. 3BDO exhibits inhibitory activity against porcine coronaviruses. 3BDO increases the protein abundance of IFITM3, inhibits virus-cell membrane fusion, and blocks viral entry. 3BDO inhibits the entry of transmissible gastroenteritis virus, porcine epidemic diarrhea virus, and porcine respiratory coronavirus into host cells. 3BDO can be used for research on porcine coronavirus infection .
Cat. No.: HY-161804
Target:
Research Areas:
GNF-2-deg is a PROTAC degrader targeting the dengue virus envelope protein (DENV E protein), with a DC50 of 0.83 μM in Huh7.5 cells. GNF-2-deg induces CRBN- and proteasome-dependent proteolysis of intracellular E protein. GNF-2-deg inhibits E protein-mediated membrane fusion and blocks viral particle production. GNF-2-deg reduces viral yield in infected cells and retains activity against E protein βOG pocket mutant virus-like particles (VLP). GNF-2-deg can be used in the research of dengue virus infection, Zika virus infection, Japanese encephalitis, West Nile virus infection and yellow fever .
Cat. No.: HY-161806
Target:
Research Areas:
ZXH-8-004 is a DENV E PROTAC degrader with a DC50 value of 0.21 µM in Huh7.5 cells. ZXH-8-004 induces CRBN- and proteasome-dependent degradation of intracellular dengue virus envelope protein. ZXH-8-004 inhibits envelope-mediated membrane fusion during viral entry and reduces the production of infectious dengue virus particles. ZXH-8-004 can be used in studies related to dengue virus infection, Zika virus infection, Japanese encephalitis virus infection, West Nile virus infection, and yellow fever virus infection .
Cat. No.: HY-107009
CAS No.: 149754-11-0
CTC 96 is an antiviral agent, showing inhibitory effects particularly on herpes viruses and adenoviruses. CTC 96 directly blocks the fusion process between the viral envelope and the cell membrane, preventing the entry of viral nucleic acids and proteins into the cells. CTC 96 can completely block the penetration and intercellular transmission of HSV-1, preventing the synthesis of viral proteins and mRNA. CTC 96 exhibits significant anti-adenovirus activity in rabbit eye models. CTC 96 is also effective against varicella-zoster virus (VZV) and vesicular stomatitis virus (VSV). CTC 96 can be used for broad-spectrum antiviral research .
Cat. No.: HY-103300
CAS No.: 1186195-63-0
Target:
Research Areas:
NPE-caged-proton is a reagent that releases protons under UV light and has the activity of activating the fusion protein GP64 under weak acidic conditions. NPE-caged-proton can promote the binding of enveloped viruses to liposome membranes with acidic phospholipids in an environment of pH 4.0 to 5.5, thereby initiating membrane fusion. The ultraviolet unblocking effect of NPE-caged-proton can lower the environmental pH, thereby triggering the process of viral membrane fusion. When studying the interaction between viruses and cell membranes, NPE-caged-proton provides a valuable tool for revealing the subtle behaviors of viruses in different chemical and biochemical environments .
Cat. No.: HY-182030
RSV fusion protein IN-1 is an orally active RSV pre-fusion F protein inhibitor with an IC50 of 0.10 nM against RSV. RSV fusion protein IN-1 forms stable hydrogen bonds and π-π stacking interactions with pre-fusion F protein to block viral fusion and entry. RSV fusion protein IN-1 suppresses RSV F protein expression in epithelial cells. RSV fusion protein IN-1 reduces viral burden in the lungs of RSV-infected murine models.RSV fusion protein IN-1 can be used for the research of respiratory syncytial virus (RSV) infection .
Cat. No.: HY-189244
CAS No.: 3103996-88-6
RSV-IN-14 is an orally active pre-fusion F protein inhibitor of respiratory syncytial virus (RSV), with a Kd of 5.0 μM, and exhibits lung-targeted distribution properties. RSV-IN-14 binds to the central cavity of the trimeric pre-fusion F protein, locks it in the pre-fusion state, and inhibits the conformational changes required for membrane fusion to block viral entry. RSV-IN-14 suppresses respiratory syncytial virus-induced syncytium formation. RSV-IN-14 can be used in studies on respiratory syncytial virus infection .
Cat. No.: HY-P991766
Target:
Research Areas:
Cat. No.: HY-183592
Target:
Research Areas:
Anti-virus agent 2 is an orally active and selective anti-orthopoxvirus (poxvirus) agent, with EC50 values of 6.1 μM and 47.1 μM against VTT-Fluc and MPXV clade IIb, respectively. Anti-virus agent 2 covalently binds to viral A17L protein and mRNA methyltransferase, blocks viral membrane fusion and intracellular biosynthesis, and acts on multiple stages of the viral replication cycle. Anti-virus agent 2 achieves viral inhibition in nude mouse models. Anti-virus agent 2 can be used for the research of orthopoxvirus infections such as monkeypox and smallpox .
Cat. No.: HY-P71685
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 fusion protein; Prev. ABL; Bcr/C-Abl Oncogene protein; JTK7; Chimeric BCR::ABL1 protein; P150; BCR::ABL1 fusion protein; C-ABL; BCR/ABL E8a2 fusion; V-Abl Abelson Murine Leukemia viral Oncogene Homolog 1; BCR/ABL1 fusion; C-Abl Oncogen
Species:
Human
Source:
E. coli
Cat. No.: HY-P77308
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 fusion protein; Prev. ABL; Bcr/C-Abl Oncogene protein; JTK7; Chimeric BCR::ABL1 protein; P150; BCR::ABL1 fusion protein; C-ABL; BCR/ABL E8a2 fusion; V-Abl Abelson Murine Leukemia viral Oncogene Homolog 1; BCR/ABL1 fusion; C-Abl Oncogen
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702716
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 fusion protein; Prev. ABL; Bcr/C-Abl Oncogene protein; JTK7; Chimeric BCR::ABL1 protein; P150; BCR::ABL1 fusion protein; C-ABL; BCR/ABL E8a2 fusion; V-Abl Abelson Murine Leukemia viral Oncogene Homolog 1; BCR/ABL1 fusion; C-Abl Oncogen
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705723
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 fusion protein; Prev. ABL; Bcr/C-Abl Oncogene protein; JTK7; Chimeric BCR::ABL1 protein; P150; BCR::ABL1 fusion protein; C-ABL; BCR/ABL E8a2 fusion; V-Abl Abelson Murine Leukemia viral Oncogene Homolog 1; BCR/ABL1 fusion; C-Abl Oncogen
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705725
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 fusion protein; Prev. ABL; Bcr/C-Abl Oncogene protein; JTK7; Chimeric BCR::ABL1 protein; P150; BCR::ABL1 fusion protein; C-ABL; BCR/ABL E8a2 fusion; V-Abl Abelson Murine Leukemia viral Oncogene Homolog 1; BCR/ABL1 fusion; C-Abl Oncogen
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705724
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 fusion protein; Prev. ABL; Bcr/C-Abl Oncogene protein; JTK7; Chimeric BCR::ABL1 protein; P150; BCR::ABL1 fusion protein; C-ABL; BCR/ABL E8a2 fusion; V-Abl Abelson Murine Leukemia viral Oncogene Homolog 1; BCR/ABL1 fusion; C-Abl Oncogen
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-N19651
CAS No.: 109175-37-3
Category:
Alkaloids Annonaceae Extract Xylopia aethiopica (Dunal) A.Rich. Quinoline Alkaloids Plants
Target:
Cat. No.: HY-P70233
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KRAS; Kras-Enoph1 fusion protein; Prev. KRAS2; PR310 C-K-Ras Oncogene; GTPase KRas; Small Monomeric GTPase; K-Ras4B; C-Kirsten-Ras protein; KRAS1; Proto-Oncogene GTPase; V-Ki-Ras2 Kirsten Rat Sarcoma 2 viral Oncogene Homolog; KRAS-ENOPH fusion; Kirsten Ra
Species:
Human
Source:
E. coli
Cat. No.: HY-P70233A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KRAS; Kras-Enoph1 fusion protein; Prev. KRAS2; PR310 C-K-Ras Oncogene; GTPase KRas; Small Monomeric GTPase; K-Ras4B; C-Kirsten-Ras protein; KRAS1; Proto-Oncogene GTPase; V-Ki-Ras2 Kirsten Rat Sarcoma 2 viral Oncogene Homolog; KRAS-ENOPH fusion; Kirsten Ra
Species:
Human
Source:
E. coli
Cat. No.: HY-P704746
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KRAS; Kras-Enoph1 fusion protein; Prev. KRAS2; PR310 C-K-Ras Oncogene; GTPase KRas; Small Monomeric GTPase; K-Ras4B; C-Kirsten-Ras protein; KRAS1; Proto-Oncogene GTPase; V-Ki-Ras2 Kirsten Rat Sarcoma 2 viral Oncogene Homolog; KRAS-ENOPH fusion; Kirsten Ra
Species:
Human
Source:
sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
