149754-11-0
Chemical Structure
CTC 96
- CAS No.: 149754-11-0
- Formula:C20H30BrCoN6O2
- Molecular Weight:525.33
InChIKey: GWSKFGOVECVEAR-SYAHETRSSA-M
SMILES: CC1=[N]2[Co+3]3(O=C(C)[CH-]1)([N]4=C(NC=C4)C)([N]5=C(NC=C5)C)[N](CC2)=C([CH-]C(C)=O3)C.[Br-]
Biological Activity: CTC 96 is an antiviral agent, showing inhibitory effects particularly on herpes viruses and adenoviruses. CTC 96 directly blocks the fusion process between the viral envelope and the cell membrane, preventing the entry of viral nucleic acids and proteins into the cells. CTC 96 can completely block the penetration and intercellular transmission of HSV-1, preventing the synthesis of viral proteins and mRNA. CTC 96 exhibits significant anti-adenovirus activity in rabbit eye models. CTC 96 is also effective against varicella-zoster virus (VZV) and vesicular stomatitis virus (VSV). CTC 96 can be used for broad-spectrum antiviral research[1][2].
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CTC 96 | CTC 96 is an antiviral agent, showing inhibitory effects particularly on herpes viruses and adenoviruses. CTC 96 directly blocks the fusion process between the viral envelope and the cell membrane, preventing the entry of viral nucleic acids and proteins into the cells. CTC 96 can completely block the penetration and intercellular transmission of HSV-1, preventing the synthesis of viral proteins and mRNA. CTC 96 exhibits significant anti-adenovirus activity in rabbit eye models. CTC 96 is also effective against varicella-zoster virus (VZV) and vesicular stomatitis virus (VSV). CTC 96 can be used for broad-spectrum antiviral research. | |||||||||||||||||||||
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- [1]. Schwartz JA, Lium EK, Silverstein SJ. Herpes simplex virus type 1 entry is inhibited by the cobalt chelate complex CTC-96. J Virol. 2001 May;75(9):4117-28. [Content Brief]
- [2]. Epstein SP, et al. Efficacy of topical cobalt chelate CTC-96 against adenovirus in a cell culture model and against adenovirus keratoconjunctivitis in a rabbit model. BMC Ophthalmol. 2006 Jun 5;6:22. [Content Brief]
Keywords
