SF 11
Based on 1 Customer Validation
SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.76%
- CAS 番号: 443292-81-7
- 分子式: C27H30N2O2S
- 分子量:446.60
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-107725
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Pancreatic Polypeptide, humanNeuropeptide Y Receptor Agonist -
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Neuropeptide Y (human,rat,mouse)Active Compound -
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BIBO3304 (Standard)Reference Standard
Neuropeptide Y Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
NPY Y2 receptor 199 nM (IC50) |
化学情報
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CAS 番号 443292-81-7
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性状 Solid
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分子量 446.60
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分子式 C27H30N2O2S
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Color White to off-white
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SMILES
OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(C(NC4=CC=C(OCC)C=C4)=S)CC3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (559.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
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データシート (271 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Domin H, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019;10(8):3454-3463. [Content Brief]
[2]. Brothers SP, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol Pharmacol. 2010;77(1):46-57. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2391 mL | 11.1957 mL | 22.3914 mL | 55.9785 mL |
| 5 mM | 0.4478 mL | 2.2391 mL | 4.4783 mL | 11.1957 mL | |
| 10 mM | 0.2239 mL | 1.1196 mL | 2.2391 mL | 5.5979 mL | |
| 15 mM | 0.1493 mL | 0.7464 mL | 1.4928 mL | 3.7319 mL | |
| 20 mM | 0.1120 mL | 0.5598 mL | 1.1196 mL | 2.7989 mL | |
| 25 mM | 0.0896 mL | 0.4478 mL | 0.8957 mL | 2.2391 mL | |
| 30 mM | 0.0746 mL | 0.3732 mL | 0.7464 mL | 1.8660 mL | |
| 40 mM | 0.0560 mL | 0.2799 mL | 0.5598 mL | 1.3995 mL | |
| 50 mM | 0.0448 mL | 0.2239 mL | 0.4478 mL | 1.1196 mL | |
| 60 mM | 0.0373 mL | 0.1866 mL | 0.3732 mL | 0.9330 mL | |
| 80 mM | 0.0280 mL | 0.1399 mL | 0.2799 mL | 0.6997 mL | |
| 100 mM | 0.0224 mL | 0.1120 mL | 0.2239 mL | 0.5598 mL |
SF 11 関連分類
HY-107731 関連分類
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