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Cat. No.: HY-D3066

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APNO-5

APNO-5 is a photoacoustic probe for in vivo nitric oxide (NO) detection. APNO-5 contains a PEGylated tetraalkylammonium group, which reduces aggregation and promotes tissue and cellular uptake. APNO-5 rapidly reacts with NO via N-nitrosation in the presence of O₂ to generate the N-nitroso product tAPNO-5, causing a 91 nm blueshift in the maximum absorption wavelength (from 764 nm to 673 nm), thereby enabling ratiometric photoacoustic imaging at excitation wavelengths of 770 nm (APNO-5) and 680 nm (tAPNO-5). APNO-5 exhibits high selectivity for NO over other reactive nitrogen species, oxidants, and biological carbonyl species.

For research use only. We do not sell to patients.

CAS No.: 2207602-75-1
Formula: C₄₈H₅₄BF₂IN₈O₅
Molecular Weight:998.71

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Please store the product under the recommended conditions in the Certificate of Analysis.

APNO-5 Chemical Structure

CAS No.: 2207602-75-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
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Biological Activity

Description

In Vivo

APNO-5 (68 μg/kg; subcutaneous injection; single administration) achieves a 1.3-fold ratiometric photoacoustic activation and enables detection of endogenous nitric oxide in an LPS-induced mouse inflammation model at a wavelength of 680 nm^[1].
APNO-5 is a high-performance ratiometric photoacoustic (PA) probe for non-invasive in vivo imaging of nitric oxide (NO) in LPS-induced mouse inflammation models; at 5 h after administration, its PA₆₈₀/PA₇₇₀ ratio increases 1.31-fold and the signal is enhanced 1.89-fold^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2207602-75-1
Molecular Weight 998.71
Formula C₄₈H₅₄BF₂IN₈O₅
SMILES

CNC1=C(C=C(C=C1)C2=CC(C3=CC=CC=C3)=C4N=C5C(C6=CC=CC=C6)=CC(C7=CC=C(C=C7)OCC8=CN(N=N8)CCOCCOCCOCC[N+](C)(C)C)=[N]5B(F)(N24)F)OC.[I-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Reinhardt CJ, et al. A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide. Journal of the American Chemical Society. 2018 Jan 24;140(3):1011-1018.

[2]. Lee MC, et al. Activity-Based Photoacoustic Probes for Detection of Disease Biomarkers beyond Oncology. ACS bio & med chem Au. 2023 Jun 21;3(3):223-232.

[3]. Li J, et al. Detection and Imaging of Active Substances in Early Atherosclerotic Lesions Using Fluorescent Probes. Chembiochem : a European journal of chemical biology. 2023 Aug 01;24(15):e202300105.

[4]. Qing Shen, et al. Stimuli-Responsive Organic Near-Infrared Photoacoustic Probes. Adv. Funct. Mater. 2023, 33, 2300023.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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