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Cat. No.: HY-P1699

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Aurantimycin A

Aurantimycin A is a pore-forming antibacterial agent. Aurantimycin A has activity against Gram-positive bacteria, including Bacillus subtilis and Listeria monocytogenes, but has no activity against Gram-negative bacteria or fungi. Aurantimycin A can be used in research related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 162478-50-4
Formula: C₃₈H₆₄N₈O₁₄
Molecular Weight:856.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aurantimycin A Chemical Structure

CAS No.: 162478-50-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

Bacterial InfectionFungal InfectionOthers

Bacterial Infection

Aurantimycin A shows an MIC of 1.28 µg/mL in B. subtilis BSAH1 after xylose-induced expression of lieAB^[4].

Bacterial Infection

Fungal Infection

Aurantimycin A (compound 1) (0.007-0.08 μg/mL; 18 h (bacteria); 42 h (fungi)) inhibits Gram-positive bacteria with MICs ranging from 0.007 to 0.08 μg/mL, and is inactive against Gram-negative bacteria and fungi at MIC >>100 μg/mL^[5].

Others

Aurantimycin A (compound 1) increases the conductivity of soybean phosphatidylcholine black lipid membranes in a concentration-dependent manner and forms membrane pores at concentrations above 0.1 µM^[1].
Aurantimycin A (compound AA) (4 h) antagonizes 5-HT- and histamine-induced contraction of guinea pig tracheal rings, with IC₅₀ values of 0.50 μM and 1.96 μM, respectively^[3].
Aurantimycin A (48-72 h) is cytotoxic to L-929 mouse fibroblasts, with an IC₅₀ of 7 ng/mL^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 162478-50-4
Molecular Weight 856.96
Formula C₃₈H₆₄N₈O₁₄
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Grigoriev P, et al. Formation of membrane pores by aurantimycins A and B, new lipopeptide antibiotics from Streptomyces aurantiacus. Bioelectrochemistry and Bioenergetics. 1995;36:57-59.

[2]. Engelgeh T, et al. ClpP2 proteasomes and SpxA1 determine Listeria monocytogenes tartrolon B hyper-resistance. PLoS genetics. 2025 Apr;21(4):e1011621.

[3]. Assem EK, et al. Pharmacological actions of a new synthetic cyclodepsipeptide, the A83586C-citropeptin hybrid, on complement C5a and G-Proteins. Inflammation Research. 2008 Apr 1;57:21.

[4]. Hauf S, et al. Elements in the LftR Repressor Operator Interface Contributing to Regulation of Aurantimycin Resistance in Listeria monocytogenes. Journal of bacteriology. 2021 Apr 21;203(10):e00503-20.

[5]. Gräfe U, et al. Aurantimycins, New Depsipeptide Antibiotics from Streptomyces Aumntiacus IMET 43917 Production, Isolation, Structure Elucidation, and Biological Activity. The Journal of antibiotics. 1995 Feb 25;48(2):119-25. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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