SLB1122168
Based on 1 publication(s) in Google Scholar
SLB1122168 is a Spinster Homolog 2 (Spns2) inhibitor. SLB1122168 inhibits Spns2-mediated sphingosine-1-phosphate (S1P) release with an IC50 of 94 nM. SLB1122168 induces lymphopenia in circulating lymphocytes in mice and rats.
For research use only. We do not sell to patients.
- CAS No.: 2999629-17-1
- Formula: C22H36ClN3O
- Molecular Weight:393.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
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Publications Citing Use of MedChemExpress (MCE) SLB1122168
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Biological Activity
Description
IC50 & Target
[1]|
S1P |
In Vitro
SLB1122168 (Compound 33p) (0.3 μM; 18-20 h) potently inhibits Spns2-mediated S1P release in mouse Spns2-transfected HeLa cells with an IC50 of 94 nM[1].
SLB1122168 (10 μM) shows no inhibitory activity against Mfsd2b-mediated S1P release from mouse red blood cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
SLB1122168 (10 mg/kg; i.p.; single dose) induces a 55% decrease in circulating lymphocytes in male Sprague-Dawley rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (female)[1]
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Dosage:10 mg/kg; 30 mg/kg
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Administration:i.p.; single dose
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Result:Induced a significant decrease in circulating lymphocytes relative to vehicle control at 4 h post-dose.
Caused no significant change in plasma S1P levels at 4 h post-dose.
Induced a dose-dependent decrease in circulating lymphocytes relative to vehicle control at 16 h post-dose.
Chemical Information
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CAS No. 2999629-17-1
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Molecular Weight 393.99
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Formula C22H36ClN3O
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SMILES
CCCCCCCCCCC1=CC=C2C(OC(NC[C@@H]3CNCC3)=N2)=C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
A Spinster-like Transporter at the Inner Membrane Complex is critical for Toxoplasma gondii cytokinesis, motility and invasion. [Abstract]2026 Jan 28;22(1):e1013886. PMID: 41604433
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SLB1122168 Related Classifications
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