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Sotiburafusp alfa

(Synonyms: HB0025)
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Sotiburafusp alfa is a bispecific fusion protein, which is a humanized VEGFR-1 extracellular domain fragment (129-228, 1-100 in the current sequence) fused via the peptide linker 101GGSGGSGGSGGSGGS115 to the N-terminus of the heavy chain (116-564) of a humanized IgG1-kappa anti-human PD-L1 heavy chain variant L352>A, L353>A. Sotiburafusp alfa also functions as a PD-L1 inhibitor and a VEGF inhibitor.

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  • Pureté : 97.37%
  • CAS No.: 2637466-37-4
  • Masse moléculaire:170.84 kDa
  • Stockage:
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Sotiburafusp alfa
  • Experimental Validation Results for Sotiburafusp alfa
  • Sotiburafusp alfa Chemical Structure
    Sotiburafusp alfa Chemical Structure
CAS No.: 2637466-37-4
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Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells labeling PD-L1 with Sotiburafusp alfa (HY-P990088, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Sotiburafusp alfa Chemical Structure
    1/16
  • Sotiburafusp alfa
  • Flow cytometric analysis of 1X106 Jurkat cells labeling PD-L1 with Sotiburafusp alfa (HY-P990088, red). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).