Tetradecyl-β-D-maltoside
Based on 1 Customer Validation
Tetradecyl-β-D-maltoside is a nonionic alkyl glycoside surfactant and absorption enhancer. Tetradecyl-β-D-maltoside, as a neutral detergent partitioning agent, stimulates Sav1866 ATPase activity through hydrogen bonding between its maltoside head group and hydrogen bond donors of the transmembrane domain. Tetradecyl-β-D-maltoside partitions into the lipid bilayer and disrupts Caco-2 monolayer integrity, reducing transepithelial electrical resistance and increasing paracellular permeability. Tetradecyl-β-D-maltoside induces endocytosis, membrane lipid fluidization, asymmetric membrane insertion, and transcellular insulin movement in nasal epithelial cells. Tetradecyl-β-D-maltoside inhibits protein aggregation by binding to hydrophobic surface regions of proteins.
For research use only. We do not sell to patients.
- Purity : 99.96%
- CAS No.: 18449-82-6
- Formula: C26H50O11
- Molecular Weight:538.67
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Tetradecyl-β-D-maltoside (400 μM; 1 h) significantly increases the permeability of mannitol, FD4, and insulin across Caco-2 monolayers in the thiol-ene microfluidic chip[3].
In human cultured bronchial epithelial cells (16HBE14o-), TDM (0.125%; 20 min) transiently reduces transepithelial electrical resistance with time-dependent recovery after removal, and increases paracellular movement of D-1-[14C]-mannitol and transcellular/transcytotic movement of radiolabeled insulin[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Tetradecyl-β-D-maltoside (0.125-0.25%; i.n.) increases intranasal absorption of calcitonin in rats[7].
Tetradecyl-β-D-maltoside (0.25%; i.n.) significantly increases the absorption and bioavailability of low-molecular-weight heparins in rats[7].
Tetradecyl-β-D-maltoside (i.n.) increases enoxaparin absorption in a dose-dependent manner in rats[7].
Tetradecyl-β-D-maltoside (0.125%; i.n.) induces vesicle formation in rat nasal mucosa, demonstrating transcellular transport[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 18449-82-6
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Appearance Solid
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Molecular Weight 538.67
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Formula C26H50O11
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
H2O : 4.17 mg/mL (7.74 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8564 mL | 9.2821 mL | 18.5642 mL | 46.4106 mL |
| 5 mM | 0.3713 mL | 1.8564 mL | 3.7128 mL | 9.2821 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tetradecyl-β-D-maltoside Related Classifications
HY-W337897 Related Classifications
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