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Art. -Nr.: HY-N13744

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Tetrahydrohonokiol

Tetrahydrohonokiol is a hydrogenated biphenyl neolignan derived from Honokiol (HY-N0003) through hydrogenation reduction. Tetrahydrohonokiol possesses potential antitumor activity. Tetrahydrohonokiol can be used for cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 35406-31-6
Formel: C₁₈H₂₂O₂
Molecular Weight:270.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tetrahydrohonokiol Chemical Structure

CAS. Nr.: 35406-31-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Tetrahydrohonokiol (10 μM; 72 h) exhibits no significant cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma, or HCT-116 colon cancer cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Proliferation Assay^[2]

View Protocol

Cell Line:

CCRF-CEM leukemia cells, U251 glioblastoma cells, HCT-116 colon cancer cells
Concentration:

10 μM
Incubation Time:

72 h
Result:

Did not show a significant cytotoxic effect against CCRF-CEM leukemia cells, U251 glioblastoma cells, or HCT-116 colon cancer cells at 10 μM.

Chemical Information

CAS. Nr. 35406-31-6
Molecular Weight 270.37
Formel C₁₈H₂₂O₂
SMILES

OC1=CC=C(C=C1C=2C=CC(O)=C(C2)CCC)CCC
Structure Classification
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Animals and Diseases

Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Fujita, et al. Honokiol, a New Phenolic Compound isolated from the Bark of Magnolia obovata THUNB. Chemical & Pharmaceutical Bulletin, vol. 20, no. 1, 1972, pp. 212–213.

[2]. Bernaskova M, et al. Synthesis of tetrahydrohonokiol derivates and their evaluation for cytotoxic activity against CCRF-CEM leukemia, U251 glioblastoma and HCT-116 colon cancer cells. Molecules (Basel, Switzerland). 2014 Jan 20;19(1):1223-37.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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