TGR5 Receptor Agonist 4
Based on 1 Customer Validation
TGR5 Receptor Agonist 4 is an agonist of Bile Acid Receptor (TGR5), with EC50 for hTGR5 and mTGR5 of 2 nM and 3 nM, respectively. TGR5 Receptor Agonist 4 plays important roles in hypoglycemic and weight loss.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.95%
- No. CAS: 1872436-42-4
- Fòrmula: C25H27ClN2O5
- Peso molecular:470.95
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Almacenamiento:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
Bile Acid Receptor[1]
Chemical Information
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No. CAS 1872436-42-4
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Appearance Oil
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Peso molecular 470.95
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Fòrmula C25H27ClN2O5
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Color White to off-white
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SMILES
COC(C=CC=C1)=C1COC(C([C@H](C2=CN=C(Cl)C=C2)C3)=C(C)N(C[C@H]4CCCO4)C3=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (212.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1234 mL | 10.6168 mL | 21.2337 mL | 53.0842 mL |
| 5 mM | 0.4247 mL | 2.1234 mL | 4.2467 mL | 10.6168 mL | |
| 10 mM | 0.2123 mL | 1.0617 mL | 2.1234 mL | 5.3084 mL | |
| 15 mM | 0.1416 mL | 0.7078 mL | 1.4156 mL | 3.5389 mL | |
| 20 mM | 0.1062 mL | 0.5308 mL | 1.0617 mL | 2.6542 mL | |
| 25 mM | 0.0849 mL | 0.4247 mL | 0.8493 mL | 2.1234 mL | |
| 30 mM | 0.0708 mL | 0.3539 mL | 0.7078 mL | 1.7695 mL | |
| 40 mM | 0.0531 mL | 0.2654 mL | 0.5308 mL | 1.3271 mL | |
| 50 mM | 0.0425 mL | 0.2123 mL | 0.4247 mL | 1.0617 mL | |
| 60 mM | 0.0354 mL | 0.1769 mL | 0.3539 mL | 0.8847 mL | |
| 80 mM | 0.0265 mL | 0.1327 mL | 0.2654 mL | 0.6636 mL | |
| 100 mM | 0.0212 mL | 0.1062 mL | 0.2123 mL | 0.5308 mL |
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