Thalidomide-NH-C10-COOH

Cat. No.: HY-130716 Pureza: 97.50%: Ficha de datos
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Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology.

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Thalidomide-NH-C10-COOH Estructura química

No. CAS : 2428400-33-1

Tamaño	Stock	Cantidad
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	Obtener un presupuesto
1 g	Obtener un presupuesto

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Based on 1 Customer Validation

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•Related Small Molecules:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Pureza y Documentación
Referencias
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Descripciòn

Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target^[1]

Cereblon

Peso molecular

457.52

Fòrmula

C₂₄H₃₁N₃O₆

No. CAS

2428400-33-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N(C1=O)C(C(N2)=O)CCC2=O)C3=C1C=CC=C3NCCCCCCCCCCC(O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 50 mg/mL (109.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1857 mL	10.9285 mL	21.8570 mL
5 mM	0.4371 mL	2.1857 mL	4.3714 mL
10 mM	0.2186 mL	1.0928 mL	2.1857 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 97.50%

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Ficha de datos (270 KB) SDS (393 KB)

COA (247 KB) HNMR (124 KB) LCMS (335 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9(1):19654. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1857 mL	10.9285 mL	21.8570 mL	54.6424 mL
	5 mM	0.4371 mL	2.1857 mL	4.3714 mL	10.9285 mL
	10 mM	0.2186 mL	1.0928 mL	2.1857 mL	5.4642 mL
	15 mM	0.1457 mL	0.7286 mL	1.4571 mL	3.6428 mL
	20 mM	0.1093 mL	0.5464 mL	1.0928 mL	2.7321 mL
	25 mM	0.0874 mL	0.4371 mL	0.8743 mL	2.1857 mL
	30 mM	0.0729 mL	0.3643 mL	0.7286 mL	1.8214 mL
	40 mM	0.0546 mL	0.2732 mL	0.5464 mL	1.3661 mL
	50 mM	0.0437 mL	0.2186 mL	0.4371 mL	1.0928 mL
	60 mM	0.0364 mL	0.1821 mL	0.3643 mL	0.9107 mL
	80 mM	0.0273 mL	0.1366 mL	0.2732 mL	0.6830 mL
	100 mM	0.0219 mL	0.1093 mL	0.2186 mL	0.5464 mL