Thozalinone
Based on 1 Customer Validation
Thozalinone is an orally active antidepressant agent. Thozalinone induces the release of Norepinephrine (HY-13715) and dopamine.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 655-05-0
- Formula: C11H12N2O2
- Molecular Weight:204.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Dopamine Receptor Isoforms
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Biological Activity
Thozalinone (30, 60, and 120 mg/kg orally) increases in motor activity in individual mice[1].
Thozalinone (2-64 mg/kg; i.p.) significantly prevents the depression caused by Tetrabenazine hexamate. All mice which are active demonstrated exploratory behavior by walking to theedge of the disk and looking over the side[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 655-05-0
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Appearance Solid
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Molecular Weight 204.23
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Formula C11H12N2O2
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Color White to off-white
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SMILES
O=C1N=C(N(C)C)OC1C2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (122.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Greenblatt EN, et al. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965 Jul;7(4):566-78. [Content Brief]
[2]. Yen-Koo HC, et al. Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice. Drug Chem Toxicol. 1985;8(6):495-502. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8964 mL | 24.4822 mL | 48.9644 mL | 122.4110 mL |
| 5 mM | 0.9793 mL | 4.8964 mL | 9.7929 mL | 24.4822 mL | |
| 10 mM | 0.4896 mL | 2.4482 mL | 4.8964 mL | 12.2411 mL | |
| 15 mM | 0.3264 mL | 1.6321 mL | 3.2643 mL | 8.1607 mL | |
| 20 mM | 0.2448 mL | 1.2241 mL | 2.4482 mL | 6.1206 mL | |
| 25 mM | 0.1959 mL | 0.9793 mL | 1.9586 mL | 4.8964 mL | |
| 30 mM | 0.1632 mL | 0.8161 mL | 1.6321 mL | 4.0804 mL | |
| 40 mM | 0.1224 mL | 0.6121 mL | 1.2241 mL | 3.0603 mL | |
| 50 mM | 0.0979 mL | 0.4896 mL | 0.9793 mL | 2.4482 mL | |
| 60 mM | 0.0816 mL | 0.4080 mL | 0.8161 mL | 2.0402 mL | |
| 80 mM | 0.0612 mL | 0.3060 mL | 0.6121 mL | 1.5301 mL | |
| 100 mM | 0.0490 mL | 0.2448 mL | 0.4896 mL | 1.2241 mL |
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