Topics

ER Stress: From Cellular Surveillance to Disease Pathogenesis

Proteostasis is the basis of cell survival.

Ferroptosis: A Key Regulator in Cancer Therapy and Beyond

Ferroptosis, a form of regulated cell death characterized by iron dependence and lipid peroxidation, has emerged as a critical player in various physiological and pathological processes.

Drug Repurposing

Nowadays, with the continuous development and progress of science and technology, the research and development of new drugs still have many problems such as high loss, high cost and long research period.

Drug Development Based on Natural Products

Chemical structure of representative natural products approved for clinical use.

Fragment-Based Drug Development

Traditional drug development is mainly through random screening from natural active products or existing compound libraries, which is inefficient and blind.

Drug Discovery Based on Targets and Signaling Pathways

Signal transduction participates in all life activities of cells and has the functions of regulating cell proliferation, metabolism, defense and adaptation.

Drug Screening

Drug screening is the process of testing a large number of compounds to determine whether they produce appropriate biochemical or cellular effects, which is usually an important step in the drug discovery pathway.

Drug Discovery

Figure 1.

Microbial Dark Matter: Progress, Challenges, And Opportunities

Microbial dark matter describes the enormous diversity of microorganisms and microbial functions that remain poorly characterized, particularly organisms not obtained in pure culture and biological information that conventional approaches have not resolved.