Microbial Dark Matter: Progress, Challenges, And Opportunities

Microbial dark matter describes the enormous diversity of microorganisms and microbial functions that remain poorly characterized, particularly organisms not obtained in pure culture and biological information that conventional approaches have not resolved. In many environments, only 0.1-1% of microorganisms have been cultivated, while a broader assessment estimates that more than 99% of bacterial and archaeal species have not been obtained in pure culture. Culture-independent metagenomics and single-cell genomics changed this landscape by providing genomic information without requiring cultivation and revealing previously inaccessible metabolic diversity, cooperation, and dependence. Increasing microbiome sampling and sequencing have further expanded the concept beyond uncultivated organisms to encompass large numbers of novel species and genes and unresolved spatiotemporal ecological and evolutionary patterns. International microbial-diversity projects and rapidly accumulating genomic resources have consequently increased knowledge of microbial diversity, although the functional diversity of microbial dark matter remains incompletely understood.

These developments establish microbial dark matter as a major resource for understanding microbial community organization, evolution, environmental biology, and human health rather than simply an experimental cultivation problem. Microbial dark matter does not operate through one universal molecular pathway; instead, genomic studies reveal organism-specific metabolic cooperation, dependence, biosynthetic pathways, and ecological interactions. Metagenomics and single-cell genomics can identify these dependencies and thereby inform cultivation strategies, while in situ cultivation directly addresses unknown growth requirements by exposing microorganisms to naturally occurring combinations of growth factors. The isolation chip, or iChip, places small numbers of environmental cells in diffusion chambers returned to their natural habitat, enabling access to microorganisms inaccessible through standard cultivation and producing reported increases in microbial recovery of 5- to 300-fold depending on the study. This strategy also connects microbial dark matter to drug discovery.

Environmental microorganisms already provide antibiotics, antitumor products, immunosuppressants, and other therapeutic products, yet most historically exploited products came from the cultivable minority. A concrete example is Eleftheria terrae, an initially undescribed soil microorganism cultivated using iChip technology that produces teixobactin. Teixobactin inhibits peptidoglycan biosynthesis, shows activity against Gram-positive organisms and mycobacteria, and reduced bacterial loads in experimental mouse infections involving MRSA and Streptococcus pneumoniae, illustrating how cultivation of previously inaccessible microorganisms can expose therapeutically relevant chemistry. The central research gap is therefore the widening difference between detecting microbial diversity and establishing its biological function. Although sequencing and international surveys have substantially increased knowledge of the extent and distribution of microbial diversity, much of the functional diversity remains mysterious, and genomic observations frequently require experimental validation.

Conventional cultivation also remains restrictive because unknown nutritional requirements, metabolic dependencies, and environmental growth factors can prevent laboratory growth. Drug discovery faces related technical limitations: uncultivated microorganisms constitute a large potential source of bioactive compounds, but accessing, cultivating, characterizing, and translating their products requires multidisciplinary technologies. Future progress can integrate metagenomics, single-cell genomics, improved cultivation, environmental diffusion systems, microbiome data mining, and artificial intelligence. AI-based approaches are increasingly being investigated for high-throughput discovery of previously unknown microbiome knowledge from expanding sequencing datasets. Combining computational prediction with experimental cultivation offers a route to connect genes and candidate organisms with metabolic phenotypes and bioactive products.

The resulting research agenda moves microbial dark matter from taxonomic discovery toward experimentally verified microbial functions, ecological interactions, and therapeutic molecules while preserving functional validation as a central challenge.

Products

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Cat. No.	Product Name	Information	Application	Publication
HY-10219	Rapamycin	Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant. Source: Streptomyces hygroscopicus	mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial Breast Cancer Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Bacterial Infection Fungal Infection Pain Non-Small Cell Lung Cancer Lung Adenocarcinoma SARS-CoV-2 Infection Obesity Lung Fibrosis	1470
HY-100558	Bafilomycin A1	Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis. Source: Streptomyces griseus strains	Proton Pump Autophagy Antibiotic Bacterial Apoptosis Infection	909
HY-15142	Doxorubicin hydrochloride	Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy. Source: Streptomyces peucetius var. Caesius	Topoisomerase ADC Payloads AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye Non-Small Cell Lung Cancer HER-2 Positive Breast Cancer Triple-Negative Breast Cancer Metastatic Breast Cancer	711
HY-14648	Dexamethasone	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research.	Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payloads Metabolic or Endocrine Disease Prostate Cancer Pancreatic Cancer Viral Infection Bacterial Infection Fungal Infection Pain Autoimmune Disease Digestive System Inflammation Cardiovascular Disease Non-Small Cell Lung Cancer Lung Squamous Cell Carcinoma Metastatic Breast Cancer SARS-CoV-2 Infection Lung Fibrosis	402
HY-Y0320	Dimethyl sulfoxide, meets analytical specification of Ch.P.	Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties. MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.	Environmental Pollutants Cholinesterase (ChE) Bacterial Cancer Inflammation or Immune System Disease Bacterial Infection	387
HY-15141	Staurosporine	Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer. Source: Streptomyces staurosporeus	PKC PKA Apoptosis Bacterial Fungal Antibiotic Digestive System Disease Prostate Cancer Bacterial Infection Fungal Infection Neurodegenerative Disease Pain Digestive System Inflammation	235
HY-13629	Etoposide	Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic Lung Cancer Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Viral Infection Bacterial Infection Digestive System Inflammation	191
HY-B2176	ATP	ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice. Source: widespread	Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial Infection Inflammation or Immune System Disease Metabolic or Endocrine Disease	178
HY-B0345A	ATP disodium salt	ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation. Source: Widespread	Endogenous Metabolite Cancer Inflammation or Immune System Disease Metabolic or Endocrine Disease	175
HY-16592	Brefeldin A	Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A inhibits HSV-1 and has anti-cancer activity. Source: Penicillium	Autophagy Mitophagy HSV Antibiotic Bacterial Digestive System Disease Breast Cancer Viral Infection Bacterial Infection Digestive System Inflammation	171
HY-B2176I	ATP disodium salt, 100 mM Solution, PCR Grade	ATP (Adenosine 5'-triphosphate) disodium salt, 100 mM Solution, PCR Grade is a central component of energy storage and metabolism in vivo. ATP disodium salt, 100 mM Solution, PCR Grade provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt, 100 mM Solution, PCR Grade is an important endogenous signaling molecule in immunity and inflammation. ATP disodium salt, 100 mM Solution, PCR Grade can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP disodium salt, 100 mM Solution, PCR Grade has anti-bacterial infection effects and can protect mice against bacterial infection in mice.	Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial Infection Inflammation or Immune System Disease Metabolic or Endocrine Disease	168
HY-L001	Bioactive Compound Library	Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. MCE owns a unique collection of 27,212 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. These can also be used for signal pathway research, drug discovery and drug repurposing, etc.	General Bioactive Screening Libraries	131
HY-L001P	Bioactive Compound Library Plus	Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. MCE owns a unique collection of 32,925 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. This library is a useful tool for signal pathway research, drug discovery and drug repurposing, etc. Bioactive Compound Library Plus, with more powerful screening capability, further complements Bioactive Compound Library (HY-L001) by adding some compounds with low solubility or solution stability (Part B) and some novel, rare or exclusive compounds (Part C) to this library. Overall, bioactive compound library plus (HY-L001P) includes tree parts: Part A, Part B and Part C. Compounds in Part A are equal to the products in HY-L001, which can be supplied in solution or solid form. Compounds in Part B and C are only supplied in solid form.	General Bioactive Screening Libraries	131
HY-L005	Epigenetics Compound Library	Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases. MCE provide a unique collection of 2,031 epigenetics-related compounds that can be used in the research of the related diseases.	Signaling Pathway Targeting Libraries	102
HY-L066	FDA Approved & Pharmacopeial Drug Library	New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or retasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs and pharmacopoeia collected compounds have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing. MCE owns a unique collection of 3,750 compounds from approved institutions such as FDA, EMA, NMPA, PMDA, etc. or pharmacopoeia such as USP, BP, JP, etc. These compounds have well-characterized bioactivities, safety and bioavailability properties. MCE FDA Approved & Pharmacopeial Drug Library is a good tool for drug repurposing which could dramatically accelerate drug development.	Drug Repurposing Series	98
HY-L004	Cell Cycle/DNA Damage Compound Library	DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair. MCE owns a unique collection of 3,522 cell cycle/DNA damage-related compounds which can be used in the research of the same.	Signaling Pathway Targeting Libraries	93
HY-L002	Anti-Infection Compound Library	An infection occurs when another organism enters a person’s body and causes disease. The organisms that cause infections are very diverse and can include things like viruses, bacteria, fungi, and parasites. The immune system is an effective barrier against infectious agents. MCE provides a unique collection of 4,884 anti-infective compounds with anti-bacterial, anti-viral, anti-fungal and anti-parasite activities that can be used for drug screening and other research in anti-microbial area.	Disease Focused Libraries	91
HY-D0985A	TMRE	Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.	Fluorescent Dye	87
HY-L084	Microbial Metabolite Library	Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine. MCE provides a unique collection of 939 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.	Metabolism Focused Libraries Natural Product Screening Libraries	87
HY-L205	High-Throughput Bioactive Compound Library	Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. MCE high-throughput bioactive compound library integrates 29,893 spot and futures bioactive compounds with confirmed biological activities and clear targets. These compounds can also be used for signal pathway research, drug discovery and drug repurposing, etc.		87
HY-L042	Glycoside Compound Library	Glycosides are compounds in which a sugar group is bonded through its anomeric carbon to another group via a glycosidic bond. Many biologically active compounds are glycosides. Glycosides comprise several important classes of compounds such as hormones, sweeteners, alkaloids, flavonoids, antibiotics, etc. The glycosidic residue can be crucial for their activity or can only improve pharmacokinetic parameters. Glycosides, which exhibit anti-inflammatory, anti-infection, anti-cancer and anti-oxidative properties, play numerous important roles in living organisms, such as streptomycin, as an aminoglycoside antibiotic, has anti-infection activity. Anthracyclines possess good antibacterial and anti-cancer activities. MCE Glycoside Compound Library contains a unique collection of 921 glycoside compounds and is a useful tool to discovery glycoside drugs.	Structure Classified Libraries	85
HY-L067	Antibiotics Library	Antibiotics are types of antimicrobial products used for the treatment and prevention of bacterial infections. Antibiotics can kill or inhibit bacterial growth. Although the target of an antibiotic is bacteria, some antibiotics also attack fungi and protozoans. However, antibiotics rarely have an effect on viruses. The major mechanism underlying antibiotics is the inhibition or regulation of enzymes involved in cell wall biosynthesis, nucleic acid metabolism and repair, protein synthesis, or disruption of membrane structure. Many of these cellular functions targeted by antibiotics are most active in multiplying cells. Since there is often overlap in these functions between prokaryotic bacterial cells and eukaryotic mammalian cells, it is not surprising that some antibiotics have also been found to be useful as anticancer agents. MCE supplies a unique collection of 748 antibiotics, including penicillins, cephalosporins, tetracyclines, macrolides, etc. MCE Antibiotics Library is a useful tool for anti-bacterial or anti-cancer drugs discovery.	Compound Characteristic Classified Libraries	85
HY-L078	Gut Microbial Metabolite Library	Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods. In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 475 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.	Metabolism Focused Libraries	85
HY-L099	Targeted Diversity Library	MCE Targeted Diversity Library contains 2,294 compounds, covering more than 1000 targets and isoforms, such as GPCRs, Ion channel, variety of kinases, etc. 1-3 compounds with high potency and selectivity were carefully selected for each target and isoform. The bioactivity information of each compound has been clearly reported in the literatures. This library is a concise collection of small molecule compounds with comprehensive target coverage, which can be used for phenotypic screening at low cost.	General Bioactive Screening Libraries	85
HY-L107	Anti-Cancer Natural Product Library	With features of enormous scaffold diversity and structural complexity, natural products (NPs) are the main sources of lead compounds and new drugs and play a highly significant role in the drug discovery and development process, especially for cancer and infectious diseases. A large number of natural products have been proven to have potential anti-tumor effects, mainly from plants, animals, Marine organisms and microorganisms. At present, derived than 60% of anti-tumor drugs come from natural sources, and they are widely used in breast, prostate and colon cancers. MCE offers a unique collection of 2,020 natural products with validated anti-cancer activity. MCE anti-cancer natural product library is a useful tool for anti-tumor drugs screening and other related research.	Disease Focused Libraries Natural Product Screening Libraries	85
HY-L181	Bioactive Compound Library Max	Bioactive small molecules are important sources of lead compounds and effective tools for drug screening. Because the target of active small molecules is clear, it is conducive to the study of mechanism. In addition, due to the large structural differences between the individual active molecules, it is easier to obtain a greater variety of lead compounds. MCE integrates the Bioactive Compound Library (HY-L001) and Novel Bioactive Compound Library (HY-L111) to form the Bioactive Compound Library Max. Bioactive Compound Library Max contains novel active small molecules, molecules that have entered the clinical stage and the market, and small molecules that have been verified by cell experiments or biochemical experiments, which fundamentally expands the number of compound libraries in the library and improves the structural diversity, and is an effective tool to start drug screening and mechanism research. MCE can provide a library of 30,147 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.	General Bioactive Screening Libraries	85
HY-L034	Anti-Aging Compound Library	Aging is a complex biological process characterized by functional decline of tissues and organs, structural degeneration, and reduced adaptability and resistance, all of which contribute to an increase in morbidity and mortality caused by multiple chronic diseases, such as Alzheimer's disease, cancer, and diabetes. Many theories, which fall into two main categories: programmed and error theories, have been proposed to explain the process of aging, but neither of them appears to be fully satisfactory. The programmed theories imply that aging relies on specific gene regulation, and the error theories emphasize the internal and environmental damages accumulated to living organisms. The damage theories proposed the nine hallmarks that were generally considered to contribute to the aging process: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. MCE Anti-Aging Compound Library contains 7,771 compounds, mainly targeting Sirtuin, mTOR, IGF-1R, AMPK, p53, Telomerase, Mitophagy, Mitochondrial Metabolism, COX, Cytochrome P450, Oxidase, etc. This library is a useful tool for anti-aging research.	Disease Focused Libraries	84
HY-L043	Lipid Compound Library	Lipids are a diverse and ubiquitous group of compounds which have many key biological functions, such as acting as structural components of cell membranes, serving as energy storage sources and participating in signaling pathways. Several studies suggest that bioactive lipids have effects on the treatment of some mental illnesses and metabolic syndrome. For example, DHA and EPA are important for monoaminergic neurotransmission, brain development and synaptic functioning, and are also correlated with a reduced risk of cancer and cardiovascular disease in clinical and animal studies. MCE supplies a unique collection of 2,028 lipid and lipid derivative related compounds including triglycerides, phospholipids, sphingolipids, steroids and their structural analogues or derivatives. MCE lipid compound library can be used for research in bioactive lipids, and high throughput screening (HTS) and high content screening (HCS).	Structure Classified Libraries	84
HY-L046	Anti-Cardiovascular Disease Compound Library	Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk. MCE supplies a unique collection of 2,468 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.	Disease Focused Libraries	84
HY-L059	Pyroptosis Compound Library	Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 2,034 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.	Signaling Pathway Targeting Libraries	84
HY-L075	Anti-Lung Cancer Compound Library	Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers. As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy. MCE offers a unique collection of 3,061 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.	Disease Focused Libraries	84
HY-L111	Novel Bioactive Compound Library	MCE Novel Bioactive Compound Library consists of 2,881 bioactive compounds with validated bioactivities tested by cell-based assays or biochemical assays. All compounds in this library are structurally novel and bioactivity diverse which makes it easier to discover new lead compounds. MCE Novel Bioactive Compound Library, as a supplement of MCE bioactive compound library (HY-L001), is a useful tool to screen new lead compounds.	General Bioactive Screening Libraries	84
HY-L146	Metabolic Enzyme Compound Library	Metabolism is the set of life-sustaining chemical reactions in organisms that maintain cell homeostasis. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of molecules including glucose metabolism, lipid metabolism and amino acid or protein metabolism within a cell or tissue. As catalysts, enzymes are crucial to metabolism as they allow a reaction to proceed more rapidly and tregulate the rate of a metabolic reaction. Due to the importance of metabolic balance in the organism, the abnormal function of metabolic enzymes often leads to the occurrence of a variety of metabolic diseases, such as diabetes, obesity, cardiovascular disease, etc. MCE designs a unique collection of 4,407 metabolic enzymes related small molecules, which is an important tool for studying the metabolic activities of organisms and developing drugs for metabolic diseases.	Signaling Pathway Targeting Libraries	84
HY-L001V	MCE Bioactive Compound Library	A unique collection of 34,325 bioactive compounds including natural products, enzyme inhibitors, receptor ligands, and drugs for high throughput screening (HTS) and high content screening (HCS).		83
HY-L005M	Epigenetics Compound Library Mini	Epigenetics involves heritable phenotypic changes that occur without alterations to the underlying DNA sequence. Key mechanisms include DNA methylation, histone modifications, and regulation by small non-coding RNAs such as microRNAs. By modifying DNA, histones, or RNA—while leaving their primary sequences intact—these processes influence molecular function and regulation, thereby playing critical roles in cellular differentiation, embryonic development, gene expression control, aging, and diseases such as cancer. MCE provide a unique collection of 295 epigenetics-related compounds. For each regulatory target and its subtype, 3 to 5 highly specific representative compounds have been retained, which can be used in epigenetic and related disease research.	Signaling Pathway Targeting Libraries	83
HY-L0117V	Asinex Macrocycles for Glycomimetics Library	Glycomimetics are designed to mimic the structure of natural carbohydrates and modulate their disease-related functions. Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites.		83
HY-L0130V	MCE Virtual Screening Compound Library2	A collection of over 10 million screening compounds from 18+ manufacturers. The data has been cleaned, suitable for virtual screening and AI screening.		83
HY-L021M	Natural Product and Natural Product-Like Compound Library	From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research. MCE provides a unique collection of 20,566 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).		83
HY-L032	Fragment Library	Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function; it can cover broad swaths of chemical space and allows the use of creative chemistry. Fragment-based drug discovery is well-established in industry and has resulted in a variety of drugs entering clinical trials, with two, vemurafenib and venetoclax, already approved. FBDD also has key attractions for academia. Notably, it is able to tackle difficult or novel targets for which no chemical matter may be found in existing HTS collections. MCE designs a unique collection of 41,368 fragment compounds, all of which obey a heuristic rule called the “Rule of Three (RO3) ”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This library is an important source of lead-like drugs.	Featured Fragment Libraries	83
HY-L100	Tumorigenesis-Related Compound Library	Cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. The administration of chemical carcinogens is one of the most commonly used methods to induce tumors in several organs in laboratory animals in order to study oncologic diseases of humans. MCE offers a unique collection of 147 chemical carcinogens which have been identified with carcinogenic activity either in humans or in animal models. MCE Tumorigenesis-Related Compound Library is a powerful tool for studying oncologic diseases of humans. Standard opration based on safety data sheet will not cause harm to the body.	Compound Characteristic Classified Libraries	83
HY-L105S	Peptide Compound Library	Peptides, composed of amino acids, serve as crucial building blocks for proteins and have gained significant attention in drug development over the past decade. The advancements in production, modification, and analytical technologies have led to a surge in the potential applications of peptides in medicine. Peptides offer a number of advantages over small molecule drugs, including: greater target specificity and efficacy, more predictable metabolic profiles, easier delivery to where they are needed in the body, and fewer side effects. Peptides are increasingly appearing in all branches of medicine as components of innovative drugs, imaging agents, diagnostic agents, and other complex drugs such as peptide-drug conjugates. To date, more than 80 peptide drugs have been approved to treat a variety of diseases, including microbial infections, obesity, anti-diabetes, and cancer, as well as to develop cell targeting platforms and improve cell penetration properties. MCE designs a unique collection of 867 peptide compounds. HY-L105S is a peptide compound library that can be provided with solution form based on HY-L105, and can be applied to peptides-based drug development.	Structure Classified Libraries	83
HY-L157	Animal-Sourced Natural Product Library	Natural product have great diversity and structural complexity of scaffolds. And the number of their drugs represents a large number of sources of new pharmacological entities, so natural products are of great significance in drug discovery. The Dictionary of Natural Products (DNP) shows that natural products mainly come from plants, animals and microorganisms, and animal sources are the second important source of natural products. Animal derived natural products exist to varying degrees in almost all forms of animals, generally secondary metabolite extracted from organisms. MCE provides a unique collection of 988 animal-sourced natural products. MCE Animal-Sourced Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).	Natural Product Screening Libraries	83
HY-L172	Immunopotentiator Compound Library	Immunity refers to the ability of the body to resist the invasion of pathogenic microorganisms and resist a variety of diseases. Immunocompromised will inevitably lead to a series of diseases. Immunopotentiator are a class of compounds that enhance immune function and induce immune response. Immunopotentiator can activate the proliferation and differentiation of one or more kinds of immune active cells in the body, promote the secretion of lymphocytes, and then enhance the immune function of the body. Immunopotentiator are mainly used in the treatment of tumors, infectious diseases and immunodeficiency diseases. In addition, immunopotentiator are often used as adjuvants in combination with vaccine antigens to enhance the immunogenicity of vaccines. MCE designs a unique collection of 150 compounds with definite or potential Immunopotentiating effect, mainly targeting the NOD-like Receptor (NLR), Toll-like Receptor (TLR), NF-κB, etc. It is an effective tool for development and research of anti-cancer, anti-infectious diseases and anti-immunodeficiency diseases compounds.	Compound Characteristic Classified Libraries	83
HY-L175	Inflammasomes related Compound Library	Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response. MCE designs a unique collection of 178 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.	Compound Characteristic Classified Libraries	83
HY-L189	Amino Acid Metabolism Compound Library	Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases. MCE designs a unique collection of 352 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.		83
HY-L203	Methylation Compound Library	Methylation is an epigenetic modification mechanism that involves adding methyl groups to molecules such as DNA and histones, which can alter gene expression without changing the DNA sequence. This process is catalyzed by enzymes such as DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs), and can be reversed by demethylases. The balance of methylation and demethylation is crucial for maintaining cellular function and genomic stability. Abnormal regulation of methylation may lead to a variety of diseases, including cancer, neurological disorders, and developmental abnormalities. A deep understanding of the molecular mechanisms of methylation metabolism is essential for developing therapeutic strategies for diseases associated with methylation dysregulation. MCE contains 351 compounds targeting methylation/demethylation enzymes, which is of significant value for studying the pathways of methylation metabolism and exploring their mechanisms of action in diseases.		83
HY-L204	Lactic Acid Metabolic Compound Library	Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism. MCE contains 582 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.		83
HY-L207	Mass Spectrometry Human Endogenous Metabolite Library	Metabolomics is the large-scale study of cellular metabolic complement, with proven utility in both basic and applied studies of plants, microorganisms, and mammals. As an important tool for the study of complex biological systems, metabolomics monitors the complex molecular networks that exist in the natural flow of information from genes to mRNA and proteins to organisms. The metabolome is composed of biomolecules that most closely resemble the phenotype of an organism, and changes in its composition can easily lead to the production of diseases. Therefore, metabolomics has received much attention in drug target discovery, drug response and translational research of disease mechanisms. Mass spectrometry-based metabolomics methods can simultaneously detect and quantify thousands of metabolite signatures, thereby characterizing the pathophysiological mechanisms of various biomedical symptoms. MCE can provide 661 mass spectrometry human endogenous metabolites that can be used for metabolite identification and quantification, functional cell detection and phenotypic screening of mass spectrometry.	Metabolism Focused Libraries	83
HY-L211	Human Hormone Compound Library	Hormones are a class of biologically active substances secreted by endocrine gland cells, which are transported through the circulatory system to various parts of the body, and precisely act on specific target organs or cells, playing a crucial role in regulating the growth, development, metabolism, and reproduction of organisms. The mechanisms of hormone action are diverse and complex. Some hormones (such as corticosteroids, vitamin D, and thyroid hormones) can enter the cell interior and interact with receptors in the nucleus, thereby regulating gene expression and affecting cell function. Other hormones (such as growth hormone and thyrotropin-releasing hormone) bind directly to receptors on the cell surface, exerting their effects by regulating enzyme activity or influencing the state of ion channels. Additionally, hormones play a key role in the study of endocrine and metabolic diseases, and are closely related to the development of diseases such as diabetes and thyroid diseases. MCE has included 86 human hormone compounds, which is of great significance for the study of human metabolic pathways, and can also be used to build a metabonomics database.		83
HY-L215	Mass Spectrometry Human Metabolite Library	Metabolomics, positioned as the systemic characterization of small-molecule metabolites within biological systems, has emerged as an indispensable analytical platform in both fundamental research and translational applications across plant sciences, microbial biotechnology, and biomedical investigations. Functioning as a critical component in multi-omics integration, this discipline deciphers the intricate molecular networks operating downstream of genomic, transcriptomic, and proteomic regulation, thereby capturing the dynamic biochemical phenotype closest to organismal functionality. The metabolome, comprising endogenous compounds with molecular weights typically below 1500 Da, serves as the functional readout of cellular processes and environmental interactions, where perturbations in metabolic networks are frequently implicated in disease pathogenesis. Such unique attributes have propelled metabolomics into a pivotal role in pharmacological research, particularly in target deconvolution, pharmacodynamic assessment, and mechanistic elucidation of pathological processes. MCE can provide 6,077 mass spectrometry human metabolites that can be used for metabolite identification and quantification, functional cell detection and phenotypic screening of mass spectrometry.	Metabolism Focused Libraries	83
HY-L216	Polysaccharides Compound Library	Polysaccharides are long chains of carbohydrate molecules, consisting of multiple smaller monosaccharides. Polysaccharides are found mainly in natural sources such as plants, microorganisms, algae and animals. Polysaccharides have a large number of active functional groups, different chemical compositions and different molecular weight ranges, which determines their diversity in nature and structure. Also in the field of medical research, polysaccharides act as a class of functional compounds and thus play a role. For example, nanocarrier construction, immunomodulation and vaccine development, new strategies for antitumor therapy, tissue regeneration engineering applications and disease diagnosis. With the advancement of glycomics and synthetic biotechnology, human beings are moving from “knowing polysaccharides” to “designing polysaccharides”, which will provide innovative solutions for materials science, precision medicine and sustainable development. MCE offers 70 polysaccharides that can be used in biomedical studies.		83
HY-L235	20 Amino Acids Library	Amino acids are indispensable building blocks for life activities and are widely involved in key biological processes such as cell signal transduction, energy metabolism, gene expression regulation, and neurotransmitter synthesis. As components of proteins, 20 kinds of amino acids make up over one million kinds of proteins in the human body. These amino acids can be classified into nine types of "essential amino acids" that the human body cannot synthesize on its own and must obtain from food, as well as eleven types of "non-essential amino acids" that the human body can synthesize on its own. MCE offers 18 kinds of amino acids provided which can be applied in research fields such as the study of amino acid metabolic processes, metabolite identification, food/cosmetic ingredient research, and the development of nutritional supplements.		83
HY-L243	Quinones Library	Quinone compounds are a significant class of natural products featuring a conjugated quinone structure, widely distributed in plants, fungi, and microorganisms. Based on their core structures, they can be primarily categorized into benzoquinones, naphthoquinones, phenanthrenequinones, and anthraquinones, among others. This structural diversity endows quinone compounds with a broad spectrum of pharmacological activities, making them key components in traditional Chinese medicine (such as rhubarb, Lithospermum erythrorhizon, and Salvia miltiorrhiza). Modern research has confirmed that their activities encompass anti-tumor, anti-inflammatory, antibacterial, antiviral, antiplatelet aggregation, and neuroprotective effects, among others, establishing them as an important source for drug development. MCE designs a unique collection of 95 quinones that all come from natural products. MCE Quinones Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).	Structure Classified Natural Product Libraries	83
HY-L245	Natural Product Diversity Scaffold Library	At the forefront of innovative drug discovery, every medicinal chemist faces the challenge of rapidly identifying high-quality hit compounds from vast repositories of chemical resources. The MCE Natural Product Diversity Scaffold Library is the result of a streamlined optimization process built upon our existing natural product collection. Adhering to the rigorous selection principle of "retaining only one representative compound per BMS scaffold", we have concentrated the diversity of thousands of compounds into a high-value, low-redundancy core set containing 2,256 compounds. All compounds are derived from natural sources, inheriting their inherent advantages of structural complexity and drug-likeness. By eliminating redundancy, the library size is significantly reduced without any compromise to chemical diversity. This approach effectively lowers the cost and time required for primary screening while simplifying downstream data analysis and structure-activity relationship (SAR) studies.	Natural Product Screening Libraries	83
HY-L250	Lactic Acid Metabolite Compound Library	In the progression of various diseases, metabolic reprogramming has emerged as a key hallmark. Lactate, as an important metabolic signaling molecule, is widely involved in tumorigenesis, immune regulation, and inflammatory responses. Particularly within the tumor microenvironment, the abnormal accumulation of lactate not only affects cellular energy metabolism but also promotes disease progression by modulating immune cell functions and mediating protein lactylation, thereby participating in epigenetic regulation and signaling networks. Therefore, systematic investigation of lactate metabolic pathways and their associated metabolites is of great significance for understanding disease mechanisms and developing novel therapeutic strategies. The MCE lactic acid metabolite compound library contains 61 compounds and is constructed around key metabolic pathways involving lactate production, transport, and utilization. This library systematically includes core intermediates from glycolysis, the tricarboxylic acid (TCA) cycle, and the lactate cycle. Focusing on disease-associated metabolic reprogramming, it is suitable for research in oncology, inflammation, and metabolic disorders. The library can be used to elucidate the roles of lactate in tumor microenvironment regulation, immune evasion, and epigenetic modifications (such as protein lactylation). In addition, it provides high-quality small-molecule resources for drug screening, facilitating the discovery of potential modulators targeting key enzymes (such as LDH) or transporters (such as MCTs) involved in lactate metabolism.	Signaling Pathway Targeting Libraries	83
HY-L252	Carbohydrate Metabolite Compound Library	Carbohydrate metabolism serves as a central hub for energy supply and biosynthesis in living organisms and plays a critical role in the onset and progression of various diseases. In recent years, studies have shown that tumor cells reprogram their energy metabolism through aerobic glycolysis (the Warburg effect) to support rapid proliferation. Immune cells also rely on specific carbohydrate metabolic pathways to regulate their activation and differentiation states, while disorders such as diabetes and metabolic syndrome arise directly from dysregulation of carbohydrate metabolism. In addition, enzymes and key metabolic nodes involved in carbohydrate metabolism have become important targets for drug discovery, and therapeutic strategies targeting glycolysis, the pentose phosphate pathway, and energy metabolism are continuously advancing the treatment of cancer and metabolic diseases. Therefore, systematic analysis of carbohydrate metabolic networks and their associated metabolites is of great significance for elucidating disease mechanisms and developing novel therapeutic approaches. The MCE Carbohydrate Metabolism Metabolite Library is constructed based on classical carbohydrate metabolic pathways and contains 76 metabolites. It systematically integrates key metabolic networks, including glycolysis, the pentose phosphate pathway, the tricarboxylic acid (TCA) cycle, monosaccharide metabolism, and sugar acid interconversions. The library comprehensively covers core metabolic nodes from glucose uptake and utilization to energy production and biosynthesis, while also incorporating important upstream and downstream intermediates. It enables accurate representation of intracellular metabolic flux dynamics and is well suited for applications such as metabolic flux analysis, target validation, and mechanistic studies. Furthermore, it provides robust support for multi-omics integration and the development of precision intervention strategies.		83
HY-L253	Fungal-Sourced Compound Library	For thousands of years, natural products have always been an important source for drug discovery. Fungi, due to their unique and diverse secondary metabolic capabilities, have become a valuable resource for natural active molecules. Since the discovery of penicillin, natural products derived from fungi have demonstrated significant application value in areas such as anti-infection, anti-tumor, immune regulation, and metabolic disease research. A large number of clinical drugs, such as antibiotics, immunosuppressants, and lipid-lowering drugs, are derived from fungal metabolites or their structurally optimized derivatives. MCE fungal-derived compound library contains 91 structurally diverse and bioactive fungal natural products and their derivatives. It can be widely applied in various research fields such as antibacterial, anti-tumor, anti-inflammatory, immune regulation, epigenetics, and cell signaling pathways, providing high-quality tools for natural product drug development and high-throughput screening.	Natural Product Screening Libraries	83
HY-L254	Bacteria-Sourced Compound Library	Bacteria-derived natural products have long been recognized as an important resource for innovative drug discovery due to their remarkable structural diversity and broad spectrum of biological activities. Microorganisms such as actinomycetes, Bacillus species, and marine bacteria can produce a wide range of small molecules with unique chemical scaffolds, showing extensive application potential in anti-infective, anticancer, immunomodulatory, and metabolic disease research. Many classic drugs, including Streptomycin, Tetracycline, and Doxorubicin, are derived from bacteria-related natural products.	Natural Product Screening Libraries	83
HY-L261	Classic FDA-Approved Drug Library	MCE Classic FDA-Approved Drug Library features a curated selection of marketed drugs that have achieved the highest prescription volumes and greatest clinical impact in global practice since 2006. The collection covers eight major therapeutic areas, including cardiovascular diseases, oncology, metabolic disorders, infectious diseases, central nervous system disorders, respiratory diseases, digestive system diseases, and immunological conditions. All compounds have been validated through long‑term clinical use and possess well‑defined molecular targets, well‑established pharmacokinetic properties, quantifiable efficacy endpoints, and comprehensive toxicological safety profiles. The library currently contains 167 representative drugs and is designed to serve as an efficient tool for drug repurposing, phenotypic screening, mechanism‑of‑action studies, and combination therapy strategy development.	Drug Repurposing Series	83
HY-L264	DNA Damage Repair Inhibitor Library	DNA damage response (DDR) is a fundamental mechanism for maintaining genomic stability. When DNA damage occurs, such as single- or double-strand breaks or replication fork stalling, cells rely on key proteins including ATM, ATR, PARP, and DNA-PK to sense the damage and transmit signals, thereby regulating DNA repair, cell-cycle arrest, and cell death. Inhibition of specific DNA repair or checkpoint pathways can prevent tumor cells from effectively repairing accumulated DNA damage, ultimately leading to tumor cell death. MCE DNA Damage Repair Inhibitor Library contains 1,544 compounds, focusing on key nodes involved in DNA damage response and DNA repair. The library covers multiple DNA repair and cell-cycle checkpoint pathways, providing a systematic compound screening tool for research on precision oncology, synthetic lethality, drug resistance mechanisms, and chemo- or radiosensitization.		83
HY-L914	Serine/Threonine Focused Covalent Fragment Library	In the research of covalent inhibitors targeting serine and threonine, scientists have found that the nucleophilicity of these hydroxyl groups is significantly enhanced due to the influence of their surrounding environment. This results in higher activity during catalytic reactions. Aspirin, which targets the non-catalytic domain serine (Ser529 in human COX1) of cyclooxygenase, exerts its anti-inflammatory effect through covalent binding. β-lactam antibiotics, which targets the catalytic domain serine of penicillin-binding proteins, interferes with bacterial cell wall synthesis. Through careful selection, we constructed a structural filter containing over 110 electrophilic groups. By analyzing the electrophilic fragments selected by the structural filter, we removed any molecules with trivial or undesirable structural features. Ultimately, we obtained 3,300 fragment molecules which can target serine and threonine residues and can be used for fragment-based covalent drug discovery.	Functional Fragment Libraries	83
HY-L917	RNA Binding Library	RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs. MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.	Focused and target libraries	83
HY-L918	Molecular Glue-like Compound Library	Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms. Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases. Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 317 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.	Focused and target libraries	83
HY-L919	MCE CNS BBB Lead-like Library	With the aging population and increasing competitive pressures, neurodegenerative diseases of the central nervous system (CNS) have become a serious medical challenge in modern society, including Parkinson's disease, Alzheimer's disease, brain tumors, and multiple sclerosis. However, the success rate of CNS drug development remains remarkably low, primarily due to the blood-brain barrier (BBB). The blood-brain barrier (BBB) is a semipermeable barrier structure that surrounds the microvasculature of the CNS. In capillaries, the wedged endothelial cells are tightly packed and wedge-shaped, lining the interior of the vessels to form extensive tight junctions. Along with a range of receptors, transporters, efflux pumps, and other cellular components, this barrier regulates the entry and exit of molecules between the bloodstream and the brain. The intact BBB blocks the passage of most blood-borne substances into the brain, preventing nearly 100% of large-molecule drugs and over 98% of small-molecule drugs from entering. Compared to non-CNS drugs, physicochemical properties such as hydrogen bonds, lipophilicity, and molecular weight significantly influence a compound's ability to cross the BBB. Using artificial intelligence (AI) algorithms to predict BBB permeability, a predicted value greater than 0.75 indicates that the compound has strong potential to cross the BBB, providing a promising starting point for CNS drug discovery.	Focused and target libraries	83
HY-L936V0	Molecular Glue Virtual Library	Molecular Glue Virtual Library is constructed using generative AI technology, integrating the structural features, activity data of known molecular glues, and interaction information of ternary complexes (target protein-E3-molecular glue). Endowed with structural novelty, drug-likeness, diversity and synthesizability, it is applicable to molecular glue-based AI drug screening and large-scale virtual screening. MCE builds this library based on high-quality molecular building blocks by virtue of robust computing power, coupled with rigorous reaction rules and optimized compound generation strategies. To ensure library quality, molecules with high synthetic difficulty, poor drug-likeness, PAINS and other undesirable molecules are excluded first. Subsequently, scaffold-based compound analysis is performed to screen drug-like diverse molecules for synthesizability evaluation; those with excessively high synthetic difficulty are removed, ultimately forming a large-scale molecular glue virtual library with structural diversity, synthesizability and drug-likeness. Compounds in the library can be synthesized in only 1-2 chemical reaction steps. With MCE’s experienced chemical synthesis team, custom synthesis of different scales from milligram to kilogram can be easily achieved to meet diverse customer needs.	AI-enabled Libraries	83
HY-L943	MCE‑18 Novelty drug‑like Library	MCE-18 stands for Medicinal Chemistry Evolution 2018, which was first published in Journal of Medicinal Chemistry in 2019 for assessing molecular novelty and three-dimensional complexity. Developed based on Clarivate global pharmaceutical patent database, this descriptor was constructed via big-data analysis covering 28,161 patented lead compounds, 1,370 approved drugs and nearly 30,000 preclinical-to-phase III drug candidates from 23 top pharmaceutical companies worldwide between 1950 and 2018, followed by structural clustering and removal of redundant outdated scaffolds for data denoising. Its scoring system integrates five core structural features including aromatic ring (AR), aliphatic heterocycle (NAR), chiral center (CHIRAL), spiro atom (SPIRO), cyclic and acyclic sp³ carbon ratio together with a quadratic topological correction factor. Breaking the limitations of the single Fsp³ parameter, MCE-18 effectively distinguishes conventional flat aromatic scaffolds from modern 3D-enriched novel chemotypes, overcoming typical drawbacks of traditional compound libraries such as scaffold redundancy, low screening hit rates and poor compatibility with allosteric and PPI-related difficult targets. This library contains over 37,000 structurally diverse compounds with favorable overall drug-likeness, suitable for high-throughput screening against canonical targets including kinases, GPCRs and proteases as well as challenging allosteric and PPI targets. Compounds comply with the developmental trend of modern novel drug discovery, supporting routine primary screening as well as early hit identification of allosteric modulators and PPI inhibitors, serving as an efficient screening resource for early-stage innovative drug discovery.	Distinctive Diversity Libraries	83
HY-L944	MCE‑18 Novelty Focused Drug‑Like Library	MCE 18 stands for Medicinal Chemistry Evolution 2018. This metric was established based on structural data of 28,161 patented lead molecules, 1,370 marketed innovative drugs, and nearly 30,000 investigational candidates from preclinical to Phase III stages across 23 major global pharmaceutical companies from 1950 to 2018. After scaffold clustering analysis, a scoring model was constructed by integrating five three dimensional scaffold characteristics, including aromatic rings (AR), non aromatic heterocycles (NAR), chiral centers (CHIRAL), spirocycles (SPIRO), and the sp³ carbon ratio in cyclic and acyclic moieties, enabling quantitative assessment of molecular scaffold novelty and three dimensional complexity. According to the score distribution of patented molecules, the top 25% of the original patent dataset was defined as the high novelty region. MCE 18 high scoring compounds selected based on this criterion can effectively avoid scaffold patent conflicts and intellectual property risks from the source. Molecules in this range typically feature a high sp³ carbon ratio, abundant chiral centers, spirocycles, and fused heterocycles with prominent three dimensional conformations. Their spatial properties allow precise matching to complex non traditional undruggable target pockets such as PPI interfaces and allosteric sites, making them ideal structural types for early stage screening of First in class drugs. MCE‑18 Novelty Focused drug‑Like library strictly selects molecules from the aforementioned high scoring range, containing more than 10,000 premium drug like molecules with highly diverse scaffolds and rich 3D diversity. It can be used for high throughput screening of well established targets such as kinases, GPCRs, and proteases, and is especially suitable for hit identification in allosteric modulation, protein–protein interactions, and various undruggable orphan targets, fully supporting early stage drug discovery for cutting edge innovat	Distinctive Diversity Libraries	83
HY-L950	7-Membered Ring Privileged Scaffold Lead-like Library	Seven-membered rings are privileged medium-sized scaffolds with distinct twist-chair conformations and greater 3D diversity than five- and six-membered rings. Their flexible conformations allow induced-fit protein binding and precise pharmacophore positioning. They also modulate Fsp³, pKa and logP to enhance solubility and permeability. Azepanes, oxepanes and benzodiazepines serve as bioisosteres for hit discovery against GPCRs, ion channels and kinases. Widely found in plant and microbial alkaloids, seven-membered heterocycles show excellent biocompatibility and target affinity. They underpin many approved drugs for CNS, cancer and infectious diseases, including diazepam, imipramine and carbamazepine. Clinical candidates further highlight their unique value. However, high transannular strain and synthetic difficulty limit their availability, leaving them rare in standard screening libraries. MCE 7 Membered Scaffold Library contains 2,792 structurally diverse, lead-like molecules covering azepanes, oxepanes, benzodiazepines and dibenzazepines. With varied substitutions, chiral centers and synthetic accessibility, it fills the shortage of medium-ring scaffolds. Ideal for HTS, virtual screening and SAR studies, these novel, patent-clear compounds offer a distinctive starting point for drug discovery in CNS disorders, oncology, antivirals and challenging targets such as PPIs.	According to Lead-like Structures	83
HY-LD002	DEL B Kit Regular Library	The discovery of hit molecule is a cornerstone of drug development. Among the diverse tools available, DNA-encoded libraries have emerged a revolutionary platform for high-throughput screening. Compared with traditional HTS, DEL features shorter screening processes, lower costs, simpler assays, and larger library capacities. DEL Construction utilizes split-and-pool synthesis, a combinatorial chemistry approach that involves iterative splitting, reaction, and pooling. This strategy enables rapid, exponential assembly of fragments in minimal steps without the need for individual compound synthesis andassoicicated isolation or purification steps, thus greatly reducing overall costs. The technology enables simultaneous affinity screeningof massive compound collections to target proteins in a single step. By coupling chemical structures with unique DNA barcodes, each compound is tagged with a distinct DNA sequence for convenient tracking and decoding.DELs readily enable the construction and efficient screening of libraries containing millions to billions of compounds. As a result, DEL screening combines the dual advantages of high efficiency and low cost, making DEL a transformative technology in modern drug discovery. The DEL kit consists of 50 independent libraries with a total scale of 100 billion compounds. It is constructed through stepwise combinatorial chemistry strategies involving 2-, 3-, and 4-round synthesis. By employing diverse scaffolds and flexible linking strategies, it encompasses various ring systems, linear frameworks, and heterocyclic structures. Screening can be achieved solely through affinity, independent of target-specific activity detection methods. This library is suitable for DEL screening against a wide range of targets.	DNA Encoded Libraries	83
HY-Y0320C	Dimethyl sulfoxide	Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Low endotoxin, can be used in various biochemical experiments such as drug dissolution.	Environmental Pollutants Cholinesterase (ChE) Bacterial Inflammation or Immune System Disease Breast Cancer	61
HY-W250163	NAD+ lithium	NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function.	Biochemical Assay Reagents Metabolic or Endocrine Disease	52
HY-D0984	TMRM	Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.	Fluorescent Dye Inflammation or Immune System Disease	44
HY-D0984A	TMRM Perchlorate	Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.	Fluorescent Dye	44
HY-D0816	Rhodamine 123	Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.	Fluorescent Dye Blood or Cardio-cerebrovascular Disease	29
HY-B0425A	Novobiocin sodium	Novobiocin (Albamycin; Cathomycin) sodium is an orally active antibiotic and Hsp-90 antagonist that also inhibits the Polθ helicase/ATPase domain with IC₅₀ values of 24 μM and 15-17 μM, respectively. Novobiocin sodium binds to Hsp90, GyrB, and POLθ, inhibiting their ATPase activity and ssDNA binding. Novobiocin sodium inhibits molecular chaperone function and DNA repair, and induces apoptosis and genomic instability. Novobiocin sodium exhibits bactericidal and antiparasitic activities. Novobiocin sodium inhibits tumor growth in vivo. Novobiocin sodium is used for research on equine piroplasmosis, ovarian cancer, breast cancer, anthrax, and melioidosis. Source: Streptomyces niveus	Antibiotic DNA/RNA Synthesis HSP Apoptosis Bacterial Parasite Breast Cancer Prostate Cancer Ovarian Cancer Bacterial Infection Parasitic Infection	14
HY-D1168	Oil Red O	Oil Red O is a fat-soluble diazol dye, with a maximum absorption at 518 nm. Oil Red O stains neutral lipids and cholesteryl esters but not biological membranes. Oil Red O can be used for detecting and quantifying hepatic steatosis in mouse liver biopsies. Oil Red O staining efficiently helps to visualize the radical changes that occur in tissues as metabolic disease occurs and progresses.	Environmental Pollutants Fluorescent Dye Metabolic or Endocrine Disease Escherichia Coli Infection	12
HY-W074143	Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride	Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3]²⁺) is an electrochemiluminescent (ECL) probe and oxygen-sensitive sensor. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to modify electrode surfaces for the detection of sulfates (S₂O₈^2-) and oxalates, based on electrochemical reactions that generate excited-state species, releasing photons through irreversible redox reactions. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride utilizes the oxygen quenching of fluorescence mechanism, where fluorescence intensity reflects the metabolic rate of living microorganisms or oxygen levels within cells/tumors, allowing for real-time detection. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride's main applications include microbial detection, antibacterial activity studies, and tumor microenvironment research.	Fluorescent Dye Cancer	11
HY-N0010	Geniposidic acid	Geniposidic acid is an orally active FXR modulator and SIRT6 activator. Geniposidic acid binds to the Ser332 and His447 sites on the FXR ligand-binding domain, thereby driving nuclear translocation, coactivator recruitment, and transcription of downstream bile acid and cholesterol metabolism-related genes. Geniposidic acid improves metabolic dysfunction-related fatty liver disease by activating the SIRT6 signaling pathway. Geniposidic acid inhibits inflammation and modulates gut microbiota to alleviate colitis. Geniposidic acid can be used in research on drug-induced liver injury, inflammatory bowel disease, metabolic dysfunction-related fatty liver disease, and metabolic dysfunction-related steatohepatitis.	FXR Sirtuin TNF Receptor Interleukin Related Metabolic or Endocrine Disease	7
HY-N9965	2'-Fucosyllactose	2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines. Source: Human milk	TNF Receptor Interleukin Related Infection Digestive System Disease Prostate Cancer Depression Pain Digestive System Inflammation Lung Fibrosis Rheumatoid Arthritis	5
HY-W040821	DL-Homocysteine	DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity.	Endogenous Metabolite Neurological, Eye or Ear Disease	4
HY-128868C	FITC-Dextran (MW 20000)	FITC-Dextran (MW 20000) is a compound belonging to the class of fluorescent dyes. It is commonly used in biomedical research as a tracer molecule to label and track cells or other biological matter. FITC-Dextran consists of fluorescein isothiocyanate (FITC) and dextran, a complex carbohydrate derived from starch. The combination of the two creates a stable fluorescent tracer that can be viewed under a microscope or quantified using specialized detection instruments.	Biochemical Assay Reagents	4
HY-D0309	Rhodamine 6G	Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.	Environmental Pollutants Fluorescent Dye Cancer	4
HY-W015346	Desaminotyrosine	Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling. Source: Saccharomyces cerevisiae	Influenza Virus Endogenous Metabolite Viral Infection	3
HY-N0658	L-Threonine	L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.	Endogenous Metabolite	3
HY-W050026	Phenylacetylglutamine	Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.	Endogenous Metabolite	3
HY-D0256A	Direct Black 38 free acid	Direct Black 38 (Chlorazol Black E; Ferristatin II disodium) free acid is a benzidine-based azo dye, a substrate of Enterococcus gallinarum, and is mainly used for textile dyeing. Direct Black 38 free acid is biodegradable after being reduced by microbial enzymes (such as Enterococcus gallinarum azoreductase), breaking the azo bonds and releasing benzidine and 4-aminobiphenyl. Direct Black 38 free acid can be used in environmental toxicology, wastewater treatment and carcinogenicity studies, but its metabolite benzidine is listed as a human carcinogen.	Biochemical Assay Reagents	2
HY-D0016	5-Cyano-2,3-di-(p-tolyl)tetrazolium chloride	5-Cyano-2,3-di-(p-tolyl)tetrazolium chloride (CTC) is a redox-sensitive red fluorescent dye. 5-Cyano-2,3-di-(p-tolyl)tetrazolium chloride can be used for detecting metabolic activity in microorganisms. The emission maximum of 5-Cyano-2,3-di-(p-tolyl)tetrazolium chloride is 602 nm.	Fluorescent Dye Lung Cancer Breast Cancer	2
HY-N9388	Andrograpanin	Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties.	p38 MAPK Infection Lung Cancer Prostate Cancer Gastric Cancer Ovarian Cancer Neurodegenerative Disease Depression Pain Obesity Lung Fibrosis Rheumatoid Arthritis	2
HY-D0944	Giemsa stain	Giemsa stain is a composite dye composed of methylene azure, methylene blue, eosin and other components. Giemsa stain stains chromatin, nuclear membranes, specific cytoplasmic components and microorganisms. Giemsa stain is used in research on cytological and parasitological staining.	Fluorescent Dye	2
HY-D0256	Direct Black 38	Direct Black 38 (Chlorazol Black E) is a benzidine-based azo dye, a substrate of Enterococcus gallinarum, and is mainly used for textile dyeing. Direct Black 38 is biodegradable after being reduced by microbial enzymes (such as Enterococcus gallinarum azoreductase), breaking the azo bonds and releasing benzidine and 4-aminobiphenyl. Direct Black 38 can be used in environmental toxicology, wastewater treatment and carcinogenicity studies, but its metabolite benzidine is listed as a human carcinogen.	Biochemical Assay Reagents	2
HY-W050026S	Phenylacetylglutamine-d5	Phenylacetylglutamine-d₅ (NSC 203800-d₅) is the deuterium labeled Phenylacetylglutamine (HY-W050026). Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.	Endogenous Metabolite Isotope-Labeled Compounds	2
HY-P990222	Anti-Mouse/Rat IL-17A Antibody (17F3)	Anti-Mouse/Rat IL-17A Antibody (17F3) is a mouse-derived IgG1κ type antibody inhibitor, targeting to mouse and rat IL-17A. Anti-Mouse IL-17A Antibody (17F3) can neutralize IL-17. Anti-Mouse/Rat IL-17A Antibody (17F3) can be used for the researches of infection, immunology and metabolic disease, such as M.intracellulare infection and diabetes. Species: Mouse	Interleukin Related Inflammation or Immune System Disease Metabolic or Endocrine Disease	2
HY-P71340	STUB1 Protein, Human	STUB1 protein is an E3 ubiquitin protein ligase that cooperates with ATXN3 to regulate ubiquitin chain length on substrates and prevent chain extension. It ubiquitinates NOS1 through Hsp70/Hsp40 and regulates chaperone complexes (Hsp70, Hsc70, Hsp90). STUB1 Protein, Human is the recombinant human-derived STUB1 protein, expressed by E. coli , with tag free. Species: Human; Source: E. coli		2
HY-112253	D-Fructose 1-phosphate	D-Fructose 1-phosphate is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level. Source: Escherichia coli	Endogenous Metabolite Metabolic or Endocrine Disease	1
HY-NP181	Testosterone/BSA	Testosterone/BSA, a conjugate of Testosterone (HY-113415) and bovine serum albumin (BSA), acts as a nuclear transporter and cytoplasmic accumulator. Testosterone/BSA can enter the nuclei of rat testicular spermatocytes, spermatids and rat liver endothelial cells, while the antigenicity of BSA remains intact. Testosterone/BSA accumulates in the cytoplasm of rat hepatocytes in granular form. Testosterone/BSA can be used to investigate the membrane-initiated or non-genomic activities of steroid hormones.	Biochemical Assay Reagents	1
HY-122515	Fulvic Acid	Fulvic Acid is a natural product, which comes from humic substances produced by microorganisms in soil. Fulvic Acid can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function. Fulvic Acid has the potential for researching chronic inflammatory diseases, including diabetes. Source: microorganisms in soil	Others Inflammation or Immune System Disease Metabolic or Endocrine Disease	1
HY-N13022	Humic acid	Humic acid is an important component of organic matter in soil and water, and serves as a plant regulator. Humic acid has multiple reactive activities such as surface adsorption, ion exchange, and complexation. Humic acid can enhance pyrene degradation by Mycobacterium NJS-1. Humic acid can inhibit the activity of superoxide dismutase and scavenge hydroxyl radicals. Humic acid is also toxic to CEM cells.	Environmental Pollutants SOD Bacterial Cancer Inflammation or Immune System Disease	1
HY-W010382S	Oxaloacetic acid-13C4	Oxaloacetic acid-¹³C₄ is the ¹³C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis.	Endogenous Metabolite Isotope-Labeled Compounds Metabolic or Endocrine Disease	1
HY-112253A	D-Fructose 1-phosphate disodium	D-Fructose 1-phosphate disodium is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate disodium acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level.	Endogenous Metabolite Metabolic or Endocrine Disease	1
HY-W013570	Acenaphthylene	Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter.	Environmental Pollutants Drug Intermediate	1
HY-N0791	Tectoridin	Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway.	Estrogen Receptor/ERR Cancer	1
HY-W011927S	4,4'-Sulfonyldiphenol-d8	4,4'-Sulfonyldiphenol-d₈ (Bisphenol S (4,4'-Sulfonyldiphenol)-d₈) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.	Isotope-Labeled Compounds Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor Cancer Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	1
HY-113362	Petroselinic acid	Petroselinic acid, a positional isomer of oleic acid, is isolated from the vegetable oil of Coriandrum sativum fruits. Petroselinic acid is used as substrate for sophorolipid fermentation. Petroselinic acid inhibits the biofilm formation in microorganisms, exhibits antibacterial and antifungal activities. Petroselinic acid is orally active.	Antibiotic Bacterial Fungal Bacterial Infection Fungal Infection	1
HY-157355	Brain Heart Infusion Broth	Brain Heart Infusion Broth (BHI) is a bacterial culture medium that can be used for microbial culture.	Biochemical Assay Reagents Bacterial Infection	1
HY-W012479	H-D-Trp-OH	H-D-Trp-OH (D-Tryptophan) is the D-isomer of tryptophan, which is occasionally found in natural peptides, such as marine toxin peptides. H-D-Trp-OH can increase intestinal microbial diversity and counteract the inhibitory effect of allergic airway inflammation on intestinal microbial diversity.	Endogenous Metabolite Ligands for E3 Ligase Metabolic or Endocrine Disease	1
HY-N0658S6	L-Threonine-13C4	L-Threonine-¹³C₄ is the ¹³C labeled L-Threonine. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.	Isotope-Labeled Compounds Endogenous Metabolite	1
HY-N0321	Caftaric acid	Caftaric acid (trans-Caftaric acid) is a polyphenolic antidiuretic, antioxidant and anti-apoptotic agent that can be hydrolyzed by intestinal microbial esterases. Caftaric acid exerts its antioxidant and potential anti-inflammatory effects mainly through intestinal microbial metabolism. Caftaric acid can reduce renal damage, restore electrolyte balance, renal function indicators and antioxidant enzyme activities in a rat albinism model, and further exert anti-oxidative stress and anti-inflammatory activities.	Others Inflammation or Immune System Disease Cardiovascular Disease Parkinson's Disease	1
HY-P990806	Anti-Mouse CD20 Antibody (MB20-11)	Anti-Mouse CD20 Antibody (MB20-11) is a kind of mouse IgG2c antibody inhibitor, targeting to CD20. Anti-Mouse CD20 Antibody (MB20-11) can deplete mature B cells in lymphoid tissues. Anti-Mouse CD20 Antibody (MB20-11) can be used for the researches of cancer, immunology and metabolic Disease, such as lymphoma and diabetes. Species: Mouse	CD20 Cancer Metabolic or Endocrine Disease Blood Disease	1
HY-W014787	Decanedioic acid	Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.	Endogenous Metabolite PROTAC Linkers Type 2 Diabetes Obesity Hepatic Fibrosis	1
HY-134433	GDP-L-fucose	GDP-L-fucose is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides, providing the fucose moiety for the oligosaccharides.The formation of GDP-L-fucose occurs through two pathways, the major ab initio metabolic pathway and the minor remedial metabolic pathway. GDP-L-fucose is associated with diabetes in rats.	Endogenous Metabolite Metabolic or Endocrine Disease	1
HY-128730	Acetyl phosphate lithium potassium	Acetyl phosphate lithium potassium is an endogenous metabolic product. Acetyl phosphate lithium potassium is a key substance in bacterial metabolic regulation, particularly in Lysine acetylation, and plays an important role in bacterial responses to environmental stress and adaptive reactions.	Endogenous Metabolite Bacterial Metabolic or Endocrine Disease Bacterial Infection	1
HY-W015061	Phenylacetylglycine	Phenylacetylglycine is a gut microbial metabolite that can activate β2AR. Phenylacetylglycine protects against cardiac injury caused by ischemia/reperfusion.	Adrenergic Receptor Apoptosis Endogenous Metabolite Cardiovascular Disease	1
HY-B0172B	Isolithocholic acid	Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.	Endogenous Metabolite Metabolic or Endocrine Disease	1
HY-K0350	Mouse Neutrophil Negative Selection Kit	MCE Mouse Neutrophil Negative Selection Kit can isolate neutrophils from single-cell suspensions of mouse bone marrow or other tissue samples.	Cell Biology Cell Isolation	1
HY-14957AS	Ozenoxacin-d3 hydrochloride	Ozenoxacin-d₃ (hydrochloride) is the deuterium labeled Ozenoxacin hydrochloride. Ozenoxacin hydrochloride is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.	Antibiotic Bacterial Inflammation or Immune System Disease	/
HY-P0230	Teixobactin	Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III.	Antibiotic Bacterial	/
HY-136436S	Ternidazole-d6 hydrochloride	Ternidazole-d₆ hydrochloride is the deuterium labeled Ternidazole hydrochloride (HY-136436). Ternidazole hydrochloride is a nitroimidazole Antibiotic with anti-pathogenic microbial activity. Ternidazole hydrochloride kills and inhibits the visible growth of Clostridium perfringens type A in vitro. Ternidazole hydrochloride helps improve the therapeutic efficacy against bacterial vaginosis, candidal vaginitis and mixed vaginitis. Ternidazole hydrochloride effectively alleviates chronic alcoholism. Ternidazole hydrochloride can be used in research related to vaginitis, pathogenic microbial infections and chronic alcoholism.	Isotope-Labeled Compounds Drug Metabolite Bacterial Antibiotic Fungal Digestive System Disease Bacterial Infection Fungal Infection Vaginitis	/
HY-P11674	Zantrutide	Zantrutide is a glucagon, gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Zantrutide can be used for the study of metabolic diseases.	GLP Receptor Metabolic or Endocrine Disease	/
HY-W017758S2	1,3-Propanediol-d2	1,3-Propanediol-d₂ is the deuterium labeled 1,3-Propanediol. 1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism.	Isotope-Labeled Compounds	/
HY-Y0882S	Hydroxylamine-15N hydrochloride	Hydroxylamine-¹⁵N hydrochloride is the ¹⁵N-labeled Hydroxylamine hydrochloride (HY-Y0882). Hydroxylamine hydrochloride is a selective Monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxylamine hydrochloride is an intermediate of nitrogen cycle in aerobic ammonium oxidizers microorganisms, such as ammonium oxidizing bacteria (AOB), ammonium oxidizing archaea (AOA) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine hydrochloride impacts NO and N2O emissions by aerobic ammonium oxidizers microorganisms and inhibits nitrite oxidizing bacteria (NOB) activity.	Isotope-Labeled Compounds Monoamine Oxidase	/
HY-157373	Bromcresol Purple Broth Base	Bromcresol Purple Broth Base can be used for microbial culture.	Biochemical Assay Reagents	/
HY-172439S	Simedeutirom	Simedeutirom is the agonist for thyroid hormone beta receptor (THRβ) and can be used for researchs of metabolic diseases, such as obesity and diabetes mellitus.	Isotope-Labeled Compounds Thyroid Hormone Receptor Metabolic or Endocrine Disease	/
HY-P991552	AFM15	AFM15 is a humanized monoclonal antibody inhibitor targeting CD3E. AFM15 can be used to study metabolic and immune system diseases, such as type 1 diabetes and inflammatory bowel disease (IBD). Species: Human	CD3 Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-E70187	Arylsulfatase G	Arylsulfatase G is a lysosomal sulfatase. Arylsulfatase G has a high degree of sequence similarity with all sulphatases and in particular with arylsulphatases. Arylsulfatase G can be used for the research of metabolic.	Others Metabolic or Endocrine Disease	/
HY-179192	10% Egg-Yolk Solution	10% Egg-Yolk Solution can be added to Egg-Yolk Salt Agar Medium (HY-179191) or egg yolk sodium chloride agar medium for 10% NaCl egg yolk emulsion microbial susceptibility testing.	Biochemical Assay Reagents	/
HY-157352	Eosin-Methylene Blue Agar	Eosin-Methylene Blue Agar (EMB Agar) is a biochemical reagent that can be used for microbial culture.	Biochemical Assay Reagents	/
HY-124033	Aspinonene	Aspinonene is a bioactive compound that has the function of regulating plant growth and defense mechanisms. It can participate in biochemical signaling pathways in plants and affect various physiological responses such as growth, defense and adaptation to environmental stress.	Biochemical Assay Reagents	/
HY-P10536	Temporin SHF	Temporin SHF is a broad-spectrum antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria and yeasts, but does not have hemolytic activity. Temporin SHF disrupts the acyl chain stacking of anionic lipid bilayers, leading to cracks and disintegration of microbial membranes. Temporin SHF can be used in the development of antimicrobial drugs.	Bacterial Infection	/
HY-14957S	Ozenoxacin-d3	Ozenoxacin-d₃ is the deuterium-labeled Ozenoxacin (HY-14957). Ozenoxacin-d₃ is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.	Isotope-Labeled Compounds	/
HY-100584S	Davercin-13C,d3	Davercin-¹³C,d₃ (Erythromycin Cyclocarbonate-¹³C,d₃) is the ¹³C-labeled Davercin (HY-100584). Davercin (Erythromycin Cyclocarbonate), derivative of Erythromycin, which is active against Gram-positive and some Gram-negative microorganisms.	Isotope-Labeled Compounds Antibiotic Bacterial Infection	/
HY-N16775	Gylongiposide I	Gylongiposide I is a selective inhibitor against the enterovirus EV71 with an EC₅₀ of 1.53 μM. Gylongiposide I exerts antiviral activity by reducing viral protein VP1 expression and viral genomic RNA levels. Gylongiposide I can be used in the development of anti-EV71 drugs related to hand, foot and mouth disease.	Enterovirus Viral Infection	/
HY-157379	YM Agar	YM Agar is a low pH growth medium for the cultivation of yeasts, molds and other acid-resistant microorganisms.	Biochemical Assay Reagents	/
HY-114346A	BODIPY FL EDA free base	ODIPY FL EDA free base is an amine-based, green fluorescent probe. The R-NH2 of ODIPY FL EDA free base can be coupled with aldehydes or ketones to form reversible Schiff base products. Convert to stable amine derivatives using reducing agents such as sodium borohydride or sodium cyanoborohydride. ODIPY FL EDA free base can be used to detect modified or normal deoxynucleotides and demonstrate DNA damage and genomic DNA methylation.	Fluorescent Dye	/
HY-W777496	Saccharin-13C6	Saccharin-¹³C₆ is the ¹³C-labeled Saccharin (HY-Y0272). Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties.	Isotope-Labeled Compounds Bacterial Inflammation or Immune System Disease	/
HY-W750458	Acid Violet 7	Acid Violet 7 is an azo dye that can be used to determine the degradation of dyes by various microorganisms.	Fluorescent Dye	/
HY-136972A	GB-1a	GB-1a (Biflavanone GB-1a) is a biflavanone HIV-1 reverse transcriptase inhibitor (IC₅₀=236 μM), with an EC₅₀ of 38.0 μM for HIV-1 replication. GB-1a can block the conversion of HIV-1 genomic RNA to DNA and can be used in research related to AIDS (HIV-1 infection). GB-1a can be naturally extracted from the heartwood of Garcinia multiflora Champ.	HIV Reverse Transcriptase HIV Infection	/
HY-W134423A	Agar, microbiology tested, for cell culture (granular)	Agar, microbiology tested, for cell culture (granular) is a hydrocolloid with gelling ability. Agar, microbiology tested, for cell culture (granular) can be used to prepare microbial culture media (for bacteria, yeasts and molds).	Biochemical Assay Reagents Bacterial Fungal Bacterial Infection Fungal Infection	/
HY-W038786S	2,4,6-Trimethylphenol-d11	2,4,6-Trimethylphenol-d₁₁ is the deuterium labeled 2,4,6-Trimethylphenol. 2,4,6-Trimethylphenol is a probe compound shown to react mainly with organic matter (3DOM*). 2,4,6-Trimethylphenol is rapidly oxidized by singlet oxygen in aqueous solution.	Isotope-Labeled Compounds	/
HY-D3406	Dusquench3 azide	Dusquench3 azide is a non-fluorescent dark quencher that absorbs emission from a nearby fluorophore without generating a fluorescent signal of its own. It contains an azide group, making it suitable for click chemistry reactions (CuAAC). Dusquench3 azide is primarily used in FRET-based nucleic acid probes, molecular beacons, and multiplex qPCR assays.	Fluorescent Dye	/
HY-D3322	Sulfo DBCO-UBQ-1	Sulfo DBCO-UBQ-1 is a click chemistry reagent uniting UBQ-1, which is a dark quencher with a polyaromatic-azo backbone that exhibits no native emission, with a sulfo group for improved hydrophilicity and DBCO for undergoing copper-free click chemistry.	Biochemical Assay Reagents	/
HY-P2274R	Argifin (Standard)	Argifin (Standard) is the analytical standard of Argifin. This product is intended for research and analytical applications. Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].	Reference Standards Parasite Infection	/
HY-122984S	Diquat-d4 dibromide	Diquat-d₄ (dibromide) is the deuterium labeled Diquat dibromide (HY-122984). Diquat dibromide is a comprehensive herbicide commonly used in the cultivation of cotton, soybeans, and other crops to combat unwanted weeds. Diquat dibromide has an IC₅₀ of 60 mg/L in the Allium root growth inhibition test.	Isotope-Labeled Compounds Herbicide	/
HY-P11338	Microcyclamide	Microcyclamide (Compound 1), a cytotoxic cyclic hexapeptide, is a microbial secondary metabolite. Microcyclamide can be isolated from the cyanobacterium Microcystis aeruginosa. Microcyclamide has moderate cytotoxicity against P388 murine leukemia cells with an IC₅₀ of 1.2 μg/mL. Microcyclamide can be used for cancers research.	Endogenous Metabolite Cancer	/
HY-10585AG	Valproic acid sodium (GMP)	Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches.	Organoid HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	/
HY-W795740	(R)-Mono-ethyl 3-acetoxyglutarate	(R)-Mono-ethyl 3-acetoxyglutarate is an important metabolic intermediate that promotes the activity of tricarboxylic acid (TCA) cycle enzymes. (R)-Mono-ethyl 3-acetoxyglutarate can help study key processes in metabolic pathways. (R)-Mono-ethyl 3-acetoxyglutarate has important application value in cell metabolism research.	Biochemical Assay Reagents	/
HY-W286059	2-Aminohexadecanoic acid	2-Aminohexadecanoic acid is a bioactive compound that has the activity of inhibiting tumor growth. 2-Aminohexadecanoic acid has been shown in studies to act on basic proteins and interfere with the proliferation of tumor cells. The uses of 2-Aminohexadecanoic acid include as a potential anti-tumor inhibitor.	Biochemical Assay Reagents	/
HY-P990262	Anti-Mouse CD8 Antibody (HB-129)	Anti-Mouse CD8 Antibody (HB-129) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD8. Anti-Mouse CD8 Antibody (HB-129) can deplete CD8⁺ T cells. Anti-Mouse CD8 Antibody (HB-129) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as P815 tumor, experimental autoimmune thyroiditis (EAT) and graft versus host disease (GVHD). Species: Mouse	Transmembrane Glycoprotein Cancer Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-P11830	UDA-6	UDA-6 is a potent calcitonin and amylin receptor agonist (DACRA). UDA-6 induces weight loss, improves metabolic and hepatic parameters, and stabilizes active receptor states in obesity rats. UDA-6 can be used for the research of obesity.	Amylin Receptor Obesity	/
HY-D3407	Dusquench2 dT phosphoramidite	Dusquench2 dT phosphoramidite is a non-fluorescent dark quencher that absorbs emission from nearby fluorophores without generating its own fluorescent signal. Featuring a dT phosphoramidite moiety, it is designed for incorporation during oligonucleotide synthesis. Dusquench2 dT phosphoramidite is primarily used in FRET-based nucleic acid probes, molecular beacons, and multiplex qPCR assays.	Fluorescent Dye	/
HY-P5020	Crotalicidin	Crotalicidin is an antimicrobial peptide and anti-tumor peptide that can effectively inhibit the activity of Gram-negative bacteria and tumor cells. Crotalicidin can be obtained from rattlesnake venom. Crotalicidin can be used in the study of microbial infections and cancer.	Bacterial Infection	/
HY-124547S	2,4-D methyl ester-d3	2,4-D methyl ester-d₃ is the deuterium labeled 2,4-D methyl ester (HY-124547). 2,4-D methyl ester is a bioactive compound with the activity of promoting the accumulation of nutritional and medicinal components. 2,4-D methyl ester can be used to enhance the production of bioactive components in Cordyceps militaris. 2,4-D methyl ester showed an inductive effect on bioactive components at specific concentrations. The application of 2,4-D methyl ester provides an effective strategy to improve the fruit quality of Cordyceps militaris. 2,4-D methyl ester, as a biostimulant, can induce dose-dependent responses in different components.	Isotope-Labeled Compounds	/
HY-W698686	β-Galactosyl-C18-ceramide	β-Galactosyl-C18-ceramide is a bioactive molecule that promotes the regulation of nerve cells, regulates protein kinase C activity, and affects hormone receptors. β-Galactosyl-C18-ceramide is widely used in neuroscience research to explore its effects on nerve cell growth and function. The regulatory function of β-Galactosyl-C18-ceramide makes it a potential application prospect in compound development and disease inhibition.	Biochemical Assay Reagents	/
HY-N6703S	ar-Turmerone-d3	ar-Turmerone-d₃ is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study.	Isotope-Labeled Compounds Apoptosis Cancer Neurological, Eye or Ear Disease Inflammation or Immune System Disease	/
HY-P10910	Vensemaglutide	Vensemaglutide is the agonist for glucagon-like peptide 1 (GLP-1) receptor. Vensemaglutide can be used in research of diabetes or other metabolic disorders.	GLP Receptor Metabolic or Endocrine Disease	/
HY-167814	Trimethylsilyl-D-(+)-mannitol	Trimethylsilyl-D-(+)-mannitol is a compound with osmoprotective activity that can effectively scavenge reactive oxygen species (ROS) and provide protection for plants and microorganisms.	Biochemical Assay Reagents	/
HY-W771025	1,4-Diiodobutane-13C4	1,4-Diiodobutane-¹³C₄ (Tetramethylene Iodide (stabilized with Copper chip)-¹³C₄) is the ¹³C-labeled 1,4-Diiodobutane (HY-W004871).	Isotope-Labeled Compounds	/
HY-P3829	Beacon (47-73)	Beacon (47-73) is a C-terminal peptide fragment 47-73 of Beacon, and Beacon is a protein of 73 amino acid. Beacon (47-73) can be used for metabolic syndrome research.	Others Metabolic or Endocrine Disease	/
HY-P11334	Cyanostatin B	Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC₅₀ = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC₅₀ value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability..	Aminopeptidase Phosphatase Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis Cancer	/
HY-P5288	BMAP-28	BMAP-28 is an antibiotic peptide and an inducer of the mitochondrial permeability transition pore. BMAP-28 induces cell death through opening of the mitochondrial permeability transition pore. BMAP-28 can be used in study of microbial infections and cancer.	Antibiotic Cancer Infection	/
HY-P2098	Alamethicin F 50	Alamethicin F 50 is an antibiotic. Alamethicin F 50 is composed of membrane-active peptide, containing 75% Alamethicin F 50/5 and 10% Alamethicin F 50/7. Alamethicin F 50 is exhibits antifungal and antibacterial activity by disrupting the integrity of microbial cell membranes, resulting in leakage of cell contents and death of the microorganisms. Alamethicin F 50 is able to reduce the surface tension of water, which can be used as a surfactant or detergent.	Antibiotic Bacterial Fungal	/
HY-P11149	Human Defensin-5 (1-9)	Human Defensin-5 (1-9) is an orally active antimicrobial peptide. Human Defensin-5 (1-9) can inhibit metabolic disorders induced by Western-style diet (WSD) or Western-style diet with fructose (WSDF). Human Defensin-5 (1-9) enhances intestinal barrier function by upregulating the gene expression of ileal tight junction protein and mucins. Human Defensin-5 (1-9) can be used for the study of obesity and related metabolic diseases.	Bacterial Infection Metabolic or Endocrine Disease	/
HY-P990873	Anti-BRCA1 Antibody (BR64)	Anti-BRCA1 Antibody (BR64) is a kind of mouse IgG1 κ chimeric antibody, targeting to human BRCA1. Anti-BRCA1 Antibody (BR64) reacts with BRCA1 (Breast cancer susceptibility gene 1) involved in tumor suppression, transcription, genomic stability, DNA repair and recombination. Anti-BRCA1 Antibody (BR64) can be used for the detections of immunofluorescence, western blot, and immunoprecipitation in cancer, such as breast and ovarian cancer. Species: Human	DNA/RNA Synthesis Cancer	/
HY-P10707A	Tpp-CAQK TFA	Tpp-CAQK TAF can bind to mitochondria, enabling the construction of an engineered mitochondrial compound, Mito-Tpp-CAQK TFA, with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury.	Endogenous Metabolite Inflammation or Immune System Disease	/
HY-113861	Propioxatin A	Propioxatin A, a secondly metabolite produced in microorganism, and is an enkephalinase B inhibitor. Source: Kitasatospora	Others Neurological, Eye or Ear Disease	/
HY-P3836	[His7] Corazonin	[His7] Corazonin, a neurohormone, induces dark color in the cuticle and epidermis of Locusta migratoria.	Endogenous Metabolite Neurological, Eye or Ear Disease	/
HY-N0658S4	L-Threonine-15N,d5	L-Threonine-¹⁵N,d₅ is the deuterium and ¹⁵N-labeled L-Threonine. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.	Isotope-Labeled Compounds Endogenous Metabolite	/
HY-121716	Pelagiomicin A	Pelagiomicin A is a novel phenazine antibiotic produced by the marine bacterium Pelagiobacter variabilis. The compound is unstable in water and small alcohols. The absolute structure of its major component, Pelagiomicin A, as well as the properties of minor amounts of other structures, were determined by spectroscopic data and synthesis. Pelagiomicin A is active against both Gram-positive and Gram-negative bacteria and exhibits antitumor activity in vitro and in vivo. Source: marine environment	Bacterial Cancer	/
HY-D3431	CFSE-Tz	CFSE-Tz is a fluorescent bioorthogonal probe constructed based on the IEDDA reaction, which is mainly used for visual tracing of amino acid uptake in living cells. The tetrazine group within the CFSE-Tz molecule quenches CFSE fluorescence via photoinduced electron transfer; after the probe specifically undergoes a bioorthogonal reaction with trans-cyclooctene-modified amino acids, the quenching effect is eliminated, and a green fluorescent signal is released, thereby dynamically monitoring the intracellular amino acid uptake process. CFSE-Tz can be applied to in vitro single-cell fluorescence imaging and studies related to amino acid metabolism in tumor cells (Ex = 495 nm, Em = 519 nm)[1][2].	Fluorescent Dye Cancer	/
HY-157375	Brain Heart Infusion Agar	Brain Heart Infusion Agar is growth medium for the cultivation of a wide variety of microorganisms.	Biochemical Assay Reagents Infection Inflammation or Immune System Disease	/
HY-N2024B	Maltose solution, 20% in H2O	Maltose solution, 20% in H₂O is a 20% aqueous maltose solution. Maltose is a disaccharide composed of two glucose molecules linked together. Maltose is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.	Endogenous Metabolite Glycosidase Metabolic or Endocrine Disease	/
HY-157347	Yeast Nitrogen Base Medium	Yeast Nitrogen Base Medium (YNB Medium) is a yeast-specific medium. Yeast Nitrogen Base Medium can be used for microbial culture. The composition of 100 mL of the medium is as follows: 6.7 g Yeast Nitrogen Base Medium and 5 g D-Glucose (HY-B0389) or other carbohydrates.	Biochemical Assay Reagents	/
HY-N12524	Cyclo(prolyltyrosyl)	Cyclo(prolyltyrosyl) is a natural compound that can be found in various microorganisms and marine sponges. Cyclo(prolyltyrosyl) has antibacterial, phytotoxic and cytotoxic properties.	Bacterial Cancer Infection	/
HY-P3116	Thiocoraline	Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC₅₀s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms.	Bacterial Cancer	/
HY-P2540	Leptin (93-105), human	Leptin (93-105), human, is the amino acids 93 to 105 fragment of human leptin. Leptin is a 167-residue peptide hormone mainly produced by adipocytes and acts in the central nervous system to primarily coordinate the metabolic adaptations to fasting.	Others Metabolic or Endocrine Disease	/
HY-P10707	Tpp-CAQK	Tpp-CAQK can bind to mitochondria, enabling the construction of an engineered mitochondrial compound, Mito-Tpp-CAQK, with excellent bioactivity. Mito-Tpp-CAQK can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury.	Endogenous Metabolite Inflammation or Immune System Disease	/
HY-P10455	Cys-Pexiganan TFA	Cys-Pexiganan TFA is an amphiphilic antimicrobial peptide. Cys-Pexiganan TFA exhibits antibacterial activities against Staphylococcus aureus and Pseudomonas aeruginosa, with MIC of 16 μg/mL and 64.0 μg/mL. Cys-Pexiganan TFA interacts with anionic phospholipids and DNA of microbial cell membranes, disintegrates the cells and leads to cell death.	Bacterial	/
HY-P10936	AQP4 (201-220)	AQP4 (201-220) is an encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica.	Aquaporin Neurological, Eye or Ear Disease Inflammation or Immune System Disease	/
HY-W250182	Methyl 6-O-(N-heptylcarbamoyl)-α-d-glucopyranoside	Hecameg is a natural product commonly used as a raw material for plant growth regulators and agricultural fertilizers. It can be used to improve the absorption and utilization efficiency of nutrients by plants, and to promote the growth and development of plants. In addition, this natural product is used as a growth factor for some microorganisms and animals	Biochemical Assay Reagents	/
HY-131557	O-Deacetylravidomycin	O-Deacetylravidomycin, a microbial metabolite discovered in Streptomyces, is an antibiotic. O-Deacetylravidomycin exhibits light-dependent antibacterial and anticancer activities.	Antibiotic Bacterial	/
HY-113218S	Acetyl-L-carnitine-d9	Acetyl-L-carnitine-d₉ (O-Acetyl-L-carnitine-d₉) is deuterium labeled Acetyl-L-carnitine. Acetyl-L-carnitine (O-Acetyl-L-carnitine) is a compound involved in human metabolic research. It has relevant applications in predicting metabolite biomarker changes using the Recon 2 metabolic reconstruction model and integrating and analyzing multiple data types, but its specific activity mechanism is not described in detail based on the existing information.	Isotope-Labeled Compounds	/
HY-W011425A	NTPO trisodium	NTPO trisodium is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO trisodium are abrogated by base excision repair (BER) but not nucleotide excision repair (NER).	Others Cancer	/
HY-D2579	Sulfo DBCO-UBQ-2	Sulfo DBCO-UBQ-2 is a click chemistry reagent combining a dark quencher, UBQ-2, with a polyaromatic-azo backbone, offering no native emission. UBQ-2 effectively quenches fluorescence in the 560-670 nm range, ideal for qPCR probes and FRET applications with orange to far-red dyes.	Biochemical Assay Reagents	/
HY-100679S	Pirlindole-d4	Pirlindole-d₄ is the d₄-labeled Pirlindole (HY-100679). Pirlindole is an orally active, selective and reversible MAO-A inhibitor with an IC₅₀ value of 250 nM. Pirlindole inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole can be used in research related to depression and enterovirus infections.	Isotope-Labeled Compounds Monoamine Oxidase Enterovirus Cancer Viral Infection Depression Epilepsy Pain Platelet Disease Muscle Relaxation and Spasm	/
HY-Y0272R	Saccharin (Standard)	Saccharin (Standard) is the analytical standard of Saccharin. This product is intended for research and analytical applications. Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties.	Reference Standards Bacterial Inflammation or Immune System Disease	/
HY-N2351	Paeonoside	Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality.	Wnt Infection Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-105047	Cholyl-Lys-fluorescein	Cholyl-Lys-fluorescein is a fluorescent-labelled bile salt and a marker of hepatic biliary transporter function. Cholyl-Lys-fluorescein can be used for metabolic research.	Biochemical Assay Reagents Metabolic or Endocrine Disease	/
HY-W017758S	1,3-Propanediol-d6	1,3-Propanediol-d₆ is the deuterium labeled 1,3-Propanediol. 1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism.	Isotope-Labeled Compounds	/
HY-P990846	Anti-Fy3 Antibody (MIMA-29)	Anti-Fy3 Antibody (MIMA-29) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Fy3. Anti-Fy3 Antibody (MIMA-29) binds to erythrocytes and induces RBC (red blood cells) clearance. Anti-Fy3 Antibody (MIMA-29) can be used for the research of metabolic disease . Species: Human	Transmembrane Glycoprotein Metabolic or Endocrine Disease	/
HY-113945	Abbeymycin	Abbeymycin is an antibiotic derived from the actinobacterium Streptomyces sp. AB-999F-52. Abbeymycin is a specifically acting antibiotic with antimicrobial activity, primarily targeting anaerobic bacteria. Abbeymycin is employed in research concerning antibiotic discovery and screening. Source: Streptomyces sp.	Antibiotic Bacterial Infection	/
HY-B2176BR	ATP dimagnesium (Standard)	ATP (dimagnesium) (Standard) is the analytical standard of ATP (dimagnesium). This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation.	Endogenous Metabolite Reference Standards Inflammation or Immune System Disease	/
HY-N12964	4-Hydroxycanthin-6-one	4-Hydroxycanthin-6-one is a novel quinoline alkaloid isolated from the stem bark of the tree Ailanthus altissima. Five other known compounds were also found in the study. The structures of the new compounds were determined by interpretation of physical and spectroscopic data, and their absolute configurations were determined by electronic circular dichroism spectroscopy and quantum chemical calculations. These compounds showed significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells, showing potential anti-inflammatory properties.	Others	/
HY-P991517	BI-836858	BI-836858 is a fully human anti-CD33 monoclonal antibody. BI-836858 reduces CD33+ cells via antibody-dependent cellular cytotoxicity (ADCC), blocks downstream signaling of S100A9/CD33, decreases the secretion of immunosuppressive cytokines and reactive oxygen species-induced genomic instability, and restores bone marrow hematopoietic function. BI-836858 is applicable to the research of myelodysplastic syndrome (MDS) and AML. Species: Human	Transmembrane Glycoprotein Reactive Oxygen Species (ROS) Leukemia/Lymphoma/Myeloma Myelodysplastic Syndrome	/
HY-W017758S1	1,3-Propanediol-d8	1,3-Propanediol-d₈ is the deuterium labeled 1,3-Propanediol. 1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism.	Isotope-Labeled Compounds	/
HY-N2024AS2	Maltose monohydrate-13C	Maltose monohydrate-¹³C is the ¹³C labeled isotope of Maltose monohydrate. Maltose monohydrate is a disaccharide composed of two glucose molecules linked together. Maltose monohydrate is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose monohydrate is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose monohydrate can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.	Isotope-Labeled Compounds Glycosidase Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-P990138	Anti-Monkey/Human CD20 Antibody (2H7)	Anti-Monkey/Human CD20 Antibody (2H7) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to monkey/human CD20. Anti-Monkey/Human CD20 Antibody (2H7) specifically depletes B cells. Anti-Monkey/Human CD20 Antibody (2H7) can be used for the researches of inflammation and metabolic disease, such as diabetes and experimental autoimmune encephalomyelitis. Species: Monkey/Human	CD20 Metabolic or Endocrine Disease Experimental Autoimmune Encephalomyelitis Experimental Autoimmune Encephalomyelitis	/
HY-W151206	Hydroxy naphthol blue disodium	Hydroxy naphthol blue disodium is an azo dye compound commonly used as an acid-base indicator (λmax = 650 nm). Within the pH range of 12 to 13, the indicator solution of Hydroxy naphthol blue disodium appears pale red in the presence of calcium ions and dark blue in the presence of disodium EDTA.	Fluorescent Dye	/
HY-N8154	Tortoside A	Tortoside A is a bioactive compound that could be found in the roots of Ilex pubescens.	Others	/
HY-D2911	Pantetheine probe PP-3	Pantetheine probe PP-3 (Compound PP-3) is an alkynyl group connector probe. Pantetheine probe PP-3 selectively enriches and maps modification sites (e.g., Ser231 on DHRS2). Pantetheine probe PP-3 is promising for research of metabolic disorders (e.g., fatty acid synthesis dysregulation).	Biochemical Assay Reagents Metabolic or Endocrine Disease	/
HY-W777859	5-Methyl cytosine-13C,15N2 hydrochloride	5-Methyl cytosine-¹³C,¹⁵N₂ hydrochloride (5-Methylcytosine hydrochloride-¹³C,¹⁵N₂) is the ¹³C- and ¹⁵N-labeled 5-Methylcytosine hydrochloride (HY-W008091A). 5-Methylcytosine hydrochloride plays a crucial role in regulating gene expression, facilitating genomic imprinting, and suppressing transposable elements, while also being intricately linked to translational fidelity and tRNA recognition.	Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis	/
HY-B1145S	Chlorhexidine-d8 dihydrochloride	Chlorhexidine-d₈ (dihydrochloride) is the deuterium labeled Chlorhexidine dihydrochloride (HY-B1145). Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis).	Isotope-Labeled Compounds Antibiotic Bacterial Necroptosis Apoptosis Infection	/
HY-B1779S5	Sucrose-13C6	Sucrose-¹³C₆ is the ¹³C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al.	Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-B1849S	Hexazinone-d6	Hexazinone-d₆ is the deuterium labeled Hexazinone. Hexazinone is a triazinone herbicide with high mobility and persistence in soil. Hexazinone is mainly degraded by soil microorganisms, and its degradation and mineralization processes are significantly affected by soil texture (faster in clay loam) and application method (mixed application can improve its bioavailability and mineralization rate). Hexazinone exhibits mild to moderate acute oral toxicity and has significant eye irritation.	Isotope-Labeled Compounds Herbicide Environmental Pollutants	/
HY-N0791R	Tectoridin (Standard)	Tectoridin (Standard) is the analytical standard of Tectoridin. This product is intended for research and analytical applications. Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway.	Reference Standards Estrogen Receptor/ERR Cancer	/
HY-N8785	Arvenin II	Arvenin II is a bioactive compound, used to be isolated from Anagallis arvesnsis.	Others	/
HY-170473	Wheat germ oil	Wheat germ oil is an oil with nutritional value, especially its high Vitamin E content. Wheat germ oil is rich in health- beneficial bioactive compounds, such as phytosterols, tocopherols, carotenoids, and omega-3 fatty acids.	Biochemical Assay Reagents	/
HY-P1513	LL-37 scrambled peptide	LL-37 scrambled peptide is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide can be used as a negative control of LL-37 peptide studies.	Bacterial Infection	/
HY-D1195	Vat Blue 2	Vat Blue 2, a indigo (HY-N0335) derivative, is a dark blue 5,5'-dibromo-4,4'-dichloroindigo dye.	Fluorescent Dye	/
HY-W540972	Primulin	Primulin is a versatile fluorescent dye and bioactive compound widely used in analytical, biological, botanical and virological studies. Primulin acts as a versatile stain that labels plant cell walls and differentiates live and dead spermatozoa via distinct fluorescence patterns. Primulin exhibits strong albumin‑binding capacity. Primulin acts as a retrograde axonal tracer in neurobiological investigations. Primulin and its derivatives inhibit HCV NS3, block dengue virus NS3-mediated ATP hydrolysis, and disrupt HCV replicase assembly.	Fluorescent Dye HCV Dengue Virus Viral Infection	/
HY-D1682	NFQ1	NFQ1 is a non-fluorescent quencher (absorption wavelength: 474 nm), and is used for a new type of One Sample Fluorescence Resonance Energy Transfer (OS-FRET) method. OS-FRET enable measurement of unquenched donor emission in the same sample. NFQ1 shows broad absorption spectrum ensuring its utility as a dark acceptor for many donors.	Fluorescent Dye	/
HY-W141788	N-Butyryl-DL-homocysteine thiolactone	N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity.	Bacterial Infection	/
HY-P10836	DN59	DN59 is a 33 amino acid peptide that mimics the dengue virus type 2 E stem region. DN59 inhibits all four serotypes of dengue virus (IC₅₀: 2-5 μM) as well as other flaviviruses. N59 causes the release of genomic RNA by interacting directly with viral particles. DN59 has antiviral activity.	Dengue Virus Infection	/
HY-D2836A	FITC-HA (MW 500000)	FITC-HA (MW 500000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).	Fluorescent Dye	/
HY-W141825	N-Acetyl-DL-phenylalanine β-naphthyl ester	N-Acetyl-DL-phenylalanine β-naphthyl ester is an aromatic amino acid ester, which functions as a chromogenic substrate for chymotrypsin and microbial serine proteases such as subtilisin.	Fluorescent Dye Infection Metabolic or Endocrine Disease	/
HY-W127808	Mesobiliverdin (microbial source)	Mesobiliverdin (microbial source) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.	Biochemical Assay Reagents	/
HY-W012846R	D-Threitol (Standard)	D-Threitol (Standard) is the analytical standard of D-Threitol (HY-W012846). This product is intended for research and analytical applications. D-Threitol is a naturally occurring four-carbon sugar alcohol and an α-glucosidase (α‑glucosidase) inhibitor with an IC₅₀ of 49 mM against yeast α-glucosidase, and it is orally active. D-Threitol modulates gut microbiota composition, increases microbial diversity, enriches beneficial bacterial genera, and restores fecal short-chain fatty acid levels. D-Threitol reduces body weight gain and fat accumulation, improves glucose tolerance and insulin sensitivity, and alleviates liver, kidney, and pancreatic tissue damage. D-Threitol inhibits hepatic accumulation of ceramides and diacylglycerols. D-Threitol preserves glomerular morphology and islet structure in diabetes models. D-Threitol is also a low-calorie sweetener. D-Threitol serves as a cryoprotective polyol that stabilizes protein structure at low temperatures. D-Threitol is used in research on type 2 diabetes and as an antifreeze agent for the Alaskan beetle.	Reference Standards Endogenous Metabolite Glycosidase Type 2 Diabetes	/
HY-W585926	Disperse polyester dark blue	Disperse Polyester Dark Blue is a chemical compound extensively employed in scientific research. It serves as a redox-active agent and functions as a probe for identifying reactive oxygen species (ROS) in cells and tissues. By accepting electrons from ROS and undergoing oxidation, Disperse Polyester Dark Blue demonstrates its redox activity. Consequently, a chemiluminescent signal is generated, which can be measured using a luminometer. The intensity of the signal directly correlates with the quantity of ROS detected within the sample.	Reactive Oxygen Species (ROS)	/
HY-W013570S	Acenaphthylene-d8	Acenaphthylene-d₈ is the deuterium labeled Acenaphthylene. Acenaphthylene is a polycyclic aromatic hydrocarbon (PAH). PAHs are derived naturally from coal and tar deposits, and produced by incomplete combustion of organic matter.	Isotope-Labeled Compounds Drug Intermediate Environmental Pollutants	/
HY-B0345AS	ATP-18O4 sodium	ATP-¹⁸O₄ (disodium salt) is the ¹⁸O labeled ATP disodium salt. ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation.	Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-W002168	1,3-Dimethylpyrazole	1,3-Dimethylpyrazole is a bioactive compound isolated from Moso Bamboo Root.	Drug Intermediate	/
HY-P990805	Anti-Human/Mouse GRP78 Antibody (C38)	Anti-Human/Mouse GRP78 Antibody (C38) is a kind of mouse IgG2b antibody inhibitor, targeting to GRP78. Anti-Human/Mouse GRP78 Antibody (C38) inhibits RhoA, ROCK and AKT activation. Anti-Human/Mouse GRP78 Antibody (C38) can be used for the researches of cancer and metabolic disease, such as melanoma and diabetes. Species: Human/Mouse	HSP Cancer Metabolic or Endocrine Disease	/
HY-W017758R	1,3-Propanediol (Standard)	1,3-Propanediol (Standard) is the analytical standard of 1,3-Propanediol. This product is intended for research and analytical applications. 1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism, which has orally active.	Reference Standards Others	/
HY-W587784	Norbixin	Norbixin is an orally active natural product with multiple activities such as retinal protection and oxidative stress regulation. Norbixin scavenges ROS, chelates metal ions, regulates plasmid and genomic DNA breakage, inhibits H₂O₂-induced mutagenesis, activates PPAR-α, modulates lipid levels, restores or regulates antioxidant enzyme activity, and alters NO levels. Norbixin prevents A2E accumulation and protects photoreceptor cells and retinal pigment epithelial cells. Norbixin is a derivative of Bixin (HY-N6884). Norbixin can be used in research related to diseases such as macular degeneration and diabetes, and also serves as a natural textile dye.	PPAR Reactive Oxygen Species (ROS) NO Synthase DNA/RNA Synthesis Retinopathy Type 1 Diabetes Type 2 Diabetes	/
HY-W014787S	Decanedioic acid-d4	Decanedioic acid-d₄ is the deuterium labeled Decanedioic acid (HY-W014787). Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.	Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-P990295	Anti-Mouse CD103 Antibody (M290)	Anti-Mouse CD103 Antibody (M290) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD103. Anti-Mouse CD103 Antibody (M290) can neutralize CD103. Anti-Mouse CD103 Antibody (M290) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as B16.gp33 tumor, colitis and diabetes. Species: Mouse	Integrin Cancer Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-W836186	Cyclo(Leu-Ala)	Cyclo(Leu-Ala) (Cyclo(alanine-leucine)) is an antimicrobial compound isolated from microorganisms and has antimicrobial activity against some plant pathogens together with other compounds.	Bacterial	/
HY-P4928A	Biotinyl-Amylin (mouse, rat) TFA	Biotinyl-Amylin (mouse, rat) TFA is a biotinylated Amylin (mouse, rat). Amylin (mouse, rat) is a 37-aminoacid pancreatic protein that exerts control over several metabolic events such as glycemia and lacticemia.	Amylin Receptor Metabolic or Endocrine Disease	/
HY-DY1054	Rhodamine 123 (solution)	Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms. Solvent and concentration: DMSO: 5 mM	Fluorescent Dye	/
HY-122496	Malvidin chloride	Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G₂/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer.	Apoptosis Cancer	/
HY-B0389F1	FITC-D-Glucose	FITC-D-Glucose is a fluorescently labeled glucose derivative and an orally effective bacterial metabolic activity detection probe. FITC-D-Glucose is applicable to the research of cholera.	Fluorescent Dye Bacterial Vibrio Cholerae Infection	/
HY-N2024AS	Maltose monohydrate-d14	Maltose monohydrate-d₁₄ is the deuterium labeled Maltose monohydrate. Maltose monohydrate is a disaccharide composed of two glucose molecules linked together. Maltose monohydrate is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose monohydrate is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose monohydrate can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.	Isotope-Labeled Compounds Glycosidase Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-W018004S	L-Homocitrulline-d3	L-Homocitrulline-d₃ is the deuterium labeled L-Homocitrulline. L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).	Isotope-Labeled Compounds Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-P2255	H3K4(Me) (1-20)	H3K4(Me) (1-20), a histone peptide. H3K4me is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci.	Histone Demethylase	/
HY-Y0882S1	Hydroxylamine-d3 hydrochloride	Hydroxylamine-d₃ (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride. Hydroxylamine hydrochloride is a selective Monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxylamine hydrochloride is an intermediate of nitrogen cycle in aerobic ammonium oxidizers microorganisms, such as ammonium oxidizing bacteria (AOB), ammonium oxidizing archaea (AOA) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine hydrochloride impacts NO and N₂O emissions by aerobic ammonium oxidizers microorganisms and inhibits nitrite oxidizing bacteria (NOB) activity.	Monoamine Oxidase Blood or Cardio-cerebrovascular Disease	/
HY-P10887	Pegevongitide	Pegevongitide (AV-001) is a Tie2 agonist. Pegevongitide resists the increased endothelial cell permeability induced by SARS-CoV-2 infection. Pegevongitide activates the angiogenin (angiogenin)/Tie2 signaling pathway. Pegevongitide reduces perivascular space dilation and upregulates perivascular Aquaporin-4 expression. Pegevongitide decreases the expression of TNF-α, PAI-1, CXCL9 and P-selectin, improves white matter integrity, enhances cognitive function and exerts neuroprotective effects. Pegevongitide improves white matter integrity in middle-aged rats with vascular dementia induced by multiple microinfarctions. Pegevongitide can be used in related research on diseases such as COVID-19 and vascular dementia.	Tie ANGPTL SARS-CoV Aquaporin TNF Receptor PAI-1 CXCR P-selectin Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease SARS-CoV-2 Infection	/
HY-59320	4-Thiazolecarboxylic acid	4-Thiazolecarboxylic acid (Compound 1e) is an intermediate. 4-Thiazolecarboxylic acid can be used in the synthesis of MGL-IN-2 (HY-177534). MGL-IN-2 inhibits wild-type MGL enzyme activity with an IC₅₀ of 0.0121 μM. 4-Thiazolecarboxylic acid can be used in the research of metabolic diseases.	Biochemical Assay Reagents Drug Intermediate Metabolic or Endocrine Disease	/
HY-157363	Tryptone Soya Agar	Tryptone Soya Agar is a general-purpose culture medium for the isolation and cultivation of fastidious and non-fastidious microorganisms or the maintenance of stock culture.	Biochemical Assay Reagents	/
HY-P2323	Lactoferricin B (4-14), bovine TFA	Lactoferricin B (4-14), bovine (TFA), a peptide corresponding to residues 4-14 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms.	Bacterial Cancer Inflammation or Immune System Disease	/
HY-N0658S	L-Threonine-15N	L-Threonine-¹⁵N is the ¹⁵N-labeled L-Threonine. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.	Isotope-Labeled Compounds Endogenous Metabolite	/
HY-P1791	Lactoferrin (17-41)	Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities.	Bacterial Fungal Apoptosis Cancer Infection	/
HY-157344	Nutrient Broth	Nutrient Broth is an important formula Broth medium and it can be used to culture microorganisms, bacteria and other organisms.	Biochemical Assay Reagents	/
HY-W011927R	4,4'-Sulfonyldiphenol (Standard)	4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.	Reference Standards Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor Drug Derivative Cancer Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	/
HY-P4928	Biotinyl-Amylin (mouse, rat)	Biotinyl-Amylin (mouse, rat) is a biotinylated Amylin (mouse, rat). Amylin (mouse, rat) is a 37-aminoacid pancreatic protein that exerts control over several metabolic events such as glycemia and lacticemia.	Amylin Receptor Metabolic or Endocrine Disease	/
HY-Y0272S	Saccharin-d4	Saccharin-d₄ is the deuterium labeled Saccharin. Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties.	Isotope-Labeled Compounds Bacterial Inflammation or Immune System Disease	/
HY-P3512	Iseganan	Iseganan is an anti-microbial peptide that is active against both Gram-positive and Gram-negative bacteria and fungi. Iseganan kills a broad-spectrum of bacteria and fungi by attaching to and destroying the integrity of the lipid cell membranes. Iseganan can be used for oral mucositis research.	Bacterial Fungal Parasite Cancer Infection	/
HY-P2258	Histone H3 (1-34)	Histone H3 (1-34) is a peptide derived from human histone isotype 3.1. Histones are the main protein components of eukaryotic chromatin. Histone variants and histone modifications modulate chromatin structure, ensuring the precise operation of cellular processes associated with genomic DNA.	Histone Methyltransferase	/
HY-W019358	2-Hydroxymethyl benzoic acid	2-Hydroxymethyl benzoic acid serves as an effective water substitute in the Passerini reaction. 2-Hydroxymethyl benzoic acid can be used for the synthesis of α-hydroxyamides, which are molecular building blocks for the synthesis of bioactive compounds.	Biochemical Assay Reagents Drug Intermediate	/
HY-W011916	Muramic acid	Muramic acid (3-O-Carboxyethyl-D-glucosamine) is a component found only in the cell walls of bacteria and blue-green algae. Muramic acid can be used to measure the biomass of microorganisms in environments such as estuaries, oceans, and soils. Source: Gram-positive bacteria	Bacterial Endogenous Metabolite Bacterial Infection	/
HY-N0658S5	L-Threonine-d2	L-Threonine-d₂ is the deuterium labeled L-Threonine. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.	Isotope-Labeled Compounds Endogenous Metabolite	/
HY-W012499S	N-Acetyl-L-methionine-d3	N-Acetyl-L-methionine-d₃ is the deuterium labeled N-Acetyl-L-methionine. N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development.	Isotope-Labeled Compounds Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-B0712S	Ceftriaxone-d3 disodium	Ceftriaxone-d₃ (disodium) is the deuterium labeled Ceftriaxone. Ceftriaxone is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.	Bacterial Antibiotic Infection	/
HY-P2148	P-113	P-113 is an antimicrobial peptide (AMP) derived from the human salivary protein histatin 5. P-113 is active against clinically important microorganisms such as Pseudomonas spp., Staphylococcus spp., and C. albicans.	Bacterial Antibiotic Infection Inflammation or Immune System Disease	/
HY-W035051	TSPP tetrasodium	TSPP tetrasodium is a photosensitizer that has shown impressive effects in in vivo regression of cancer and microorganism infections (Ex: 413 nm, Em: 640 nm).	MOFs Fluorescent Dye Cancer Infection	/
HY-N2584	(2S)-Isoxanthohumol	(2S)-Isoxanthohumol is a microbial biotransformed metabolite of the hop prenylflavanone Isoxanthohumol.	Others Cancer	/
HY-P1791B	Lactoferrin (17-41) acetate	Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities.	Bacterial Fungal Apoptosis Cancer Digestive System Disease Bacterial Infection Fungal Infection Digestive System Inflammation	/
HY-128454	Dimethyl trisulfide	Dimethyl trisulfide is a cyanide scavenger. Dimethyl trisulfide can be isolated from garlic, onions, broccoli and similar plants. Dimethyl trisulfide converts cyanide into thiocyanate. Dimethyl trisulfide is used by saprophagous insects to locate breeding sites (decaying organic matter), and is also used by deceptive flowers in brood sites to attract such insects. Dimethyl trisulfide induces electrophysiological responses in houseflies. Source: marine Rhodobacteraceae species	Environmental Pollutants Biochemical Assay Reagents Infection Neurological, Eye or Ear Disease	/
HY-D1603	BODIPY FL-EDA	BODIPY FL-EDA is a widely used fluorescent dye for quantitative analysis of nucleotides. BODIPY FL-EDA is an aliphatic amine analog that can react with aldehydes and ketones. BODIPY FL-EDA can be used to detect both modified and unmodified deoxynucleotides and to determine DNA damage and genomic DNA methylation through capillary electrophoresis with laser-induced fluorescence (CE-LIF). Additionally, it can be used for quantifying intracellular ATP levels. The excitation wavelength is 500 nm, and the emission wavelength is 510 nm.	Fluorescent Dye	/
HY-157347A	Yeast Nitrogen Base Medium without Amino Acids	Yeast Nitrogen Base Medium without Amino Acids (YNB Medium without Amino Acids) is a growth medium that lacks amino acids. Yeast Nitrogen Base Medium without Amino Acids can be used for the cultivation of yeast.	Biochemical Assay Reagents	/
HY-N7195	12-Deoxywithastramonolide	12-Deoxywithastramonolide is a principle bioactive compound found in ashwagandha (W. somnifera). 12-Deoxywithastramonolide possesses antioxidant and enzyme inhibitory effects.	Others	/
HY-157374	Beef Heart Infusion	Beef Heart Infusion is a non-selective microbial culture medium formulation. Beef Heart Infusion provides nutrients for microbial growth. Beef Heart Infusion can be used for the culture, transplantation and rejuvenation of microorganisms.	Biochemical Assay Reagents	/
HY-N0658S1	L-Threonine-d5	L-Threonine-d₅ is the deuterium labeled L-Threonine. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.	Isotope-Labeled Compounds Endogenous Metabolite	/
HY-N0658S3	L-Threonine-13C4,15N	L-Threonine-¹³C₄,¹⁵N is the ¹³C- and ¹⁵N-labeled L-Threonine. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed.	Isotope-Labeled Compounds Endogenous Metabolite	/
HY-P2124	Cyclo(L-Trp-L-Trp)	Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research.	Antibiotic Bacterial Bacterial Infection	/
HY-N0181A	Lumisterol	Lumisterol (9β,10α-Ergosterol) is a photoproduct of 7-dehydrocholesterol, present in the skin, and acts as an orally active VDR non-genomic modulator and ROR inverse agonist. Lumisterol binds to the SARS-CoV-2 Mpro substrate-binding pocket and the RdRP active site, inhibiting enzyme activity. Lumisterol induces NRF2-regulated antioxidant responses, p53 phosphorylation and nuclear translocation, and intracellular free radical scavenging. Lumisterol inhibits the proliferation of epidermal keratinocytes and melanoma cells, modulates cell cycle progression, and suppresses basal and TNFα-induced NFκB transcriptional activity. Lumisterol inhibits RORγ transcriptional activity and IL-17 production. Lumisterol is used in research on UVB-induced skin damage, melanoma, psoriasis, vitamin D deficiency, and COVID-19.	Endogenous Metabolite VD/VDR ROR Keap1-Nrf2 MDM-2/p53 Free Radical Scavengers NF-κB TNF Receptor Interleukin Related Metabolic or Endocrine Disease Melanoma Coronavirus Infection Skin Disease Psoriasis	/
HY-P2274	Argifin	Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively. Source: Gliocladium sp	Parasite Parasitic Infection	/
HY-B1713A	DL-Ornithine hydrochloride	DL-Ornithine (DL-(±)-Ornithine) hydrochloride is an amino acid and also a urea cycle promoter. DL-Ornithine hydrochloride has the characteristics of low metabolic rate and rapid excretion, and only the L-enantiomer undergoes decarboxylation. In mice inoculated with L-1210 leukemia cells, DL-Ornithine hydrochloride is excreted in urine in its original form, and its conversion to carbon dioxide within 24 h is negligible. DL-Ornithine hydrochloride is mainly used in the urea cycle to eliminate excess nitrogen in the body and protect the kidneys.	Endogenous Metabolite Amino Acid/Protein Metabolism	/
HY-P1513A	LL-37 scrambled peptide acetate	LL-37 scrambled peptide acetate is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide acetate can be used as a negative control of LL-37 peptide studies.	Bacterial Infection	/
HY-157346A	LB Agar	LB Agar is a nutrient-rich bacterial medium prepared by adding Agar to lysogeny broth (LB). LB Agar supports the growth of Enterobacteriaceae, Escherichia coli, related intestinal species, and various facultative microorganisms. LB Agar is used for Escherichia coli plaque assays.	Biochemical Assay Reagents Bacterial Bacterial Infection	/
HY-W251393	S-(2-Carboxypropyl)-L-cysteine	S-(2-Carboxypropyl)-L-cysteine (β-Isobuteine) is a urine metabolite, a metabolic marker of leigh-like syndrome.	Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-101876	Rhodamine 800	Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms.	Fluorescent Dye	/
HY-W023331	(R)-b-Aminoisobutyric acid	(R)-β-Aminoisobutyric acid is a β-amino acid. (R)-β-Aminoisobutyric acid boosts myeloperoxidase microbicidal activity against susceptible microorganisms. (R)-β-Aminoisobutyric acid can be used for the research of bacterial infections.	Glutathione Peroxidase Bacterial Bacterial Infection	/
HY-W012846	D-Threitol	D-Threitol is a naturally occurring four-carbon sugar alcohol and an α-glucosidase (α‑glucosidase) inhibitor with an IC₅₀ of 49 mM against yeast α-glucosidase, and it is orally active. D-Threitol modulates gut microbiota composition, increases microbial diversity, enriches beneficial bacterial genera, and restores fecal short-chain fatty acid levels. D-Threitol reduces body weight gain and fat accumulation, improves glucose tolerance and insulin sensitivity, and alleviates liver, kidney, and pancreatic tissue damage. D-Threitol inhibits hepatic accumulation of ceramides and diacylglycerols. D-Threitol preserves glomerular morphology and islet structure in diabetes models. D-Threitol is also a low-calorie sweetener. D-Threitol serves as a cryoprotective polyol that stabilizes protein structure at low temperatures. D-Threitol is used in research on type 2 diabetes and as an antifreeze agent for the Alaskan beetle.	Endogenous Metabolite Glycosidase Type 2 Diabetes	/
HY-113382	N-Methylhydantoin	N-Methylhydantoin is a creatinine degradation metabolite and non-substrate for microbial degradation.N-Methylhydantoin resists breakdown by most tested cytosine deaminase-forming microorganisms, which lack N-methylhydantoin amidohydrolase and N-carbamoylsarcosine amidohydrolase activity.N-Methylhydantoin forms as a product of creatinine hydrolysis by cytosine deaminase/creatinine deiminase in various microorganisms.	Endogenous Metabolite Bacterial Infection	/
HY-DY1042	TMRM Perchlorate (solution)	Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms. Solvent and concentration: DMSO: 10 mM	Fluorescent Dye	/
HY-W009544	3-Hydroxytetradecanoic acid	3-Hydroxytetradecanoic acidis a saturated fatty acid. 3-Hydroxytetradecanoic acidOccurs naturally in various animal and plant sources such as butter and milk fat. 3-Hydroxytetradecanoic acidIt has various uses in industry, especially in the production of soaps, detergents and other surfactants. 3-Hydroxytetradecanoic acidIt is also used as a precursor for the synthesis of other bioactive compounds such as antibiotics and anticancer drugs.	Biochemical Assay Reagents	/
HY-42984	BHQ-2 NHS	BHQ-2 NHS is a fluorescence dark quencher with an absorption spectrum spanning 550-650 nm that overlaps with tetramethylrhodamine (TMR) emission. BHQ-2 NHS quenches TMR fluorescence when conjugated to mesoporous silica nanoparticles. BHQ-2 NHS can be used for the research of cancer.	Biochemical Assay Reagents Fluorescent Dye Cancer	/
HY-DY1023	TMRE (solution)	Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms. Solvent and concentration: DMSO: 10 mM	Fluorescent Dye	/
HY-P11666	Brenipatide	Brenipatide (LY-3537031) is a dual glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) receptor agonist. Brenipatide can be used for the study of metabolic disorders, obesity and diabetes.	GLP Receptor Glucose Metabolism Obesity	/
HY-W015969	1-Aminopropan-2-ol	1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas. Source: Pseudomonas sp. N.C.I.B. 8858	Environmental Pollutants Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-P1629	Temporin A	Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans).	Bacterial Fungal Antibiotic Infection	/
HY-N0357	3,29-Dibenzoyl rarounitriol	3,29-Dibenzoyl rarounitriol is one major bioactive compound of multiflorane triterpene esters Trichosanthes kirilowii, can be chosen as the marker for quantitation of Trichosanthes kirilowii.	Others	/
HY-D2919	DMN-Tre	DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling. DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis.	Fluorescent Dye Bacterial Infection	/
HY-W020005	2-Carboxyphenol-d4	2-Carboxyphenol-d4 is the deuterium labeled 2-Carboxyphenol. 2-Carboxyphenol is a plant hormone and mediates host responses against microbial pathogens.	Isotope-Labeled Compounds	/
HY-119809	Violacein	Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer. Source: Chromobacterium violaceum	Apoptosis Endogenous Metabolite Cancer	/
HY-N0881	Desacetylcinobufagin	Desacetylcinobufagin is a natural compound used for microbial transformation. Source: toad	Others	/
HY-113462	α-Carotene	α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer agents. α-Carotene is isolated from yellow-orange and dark-green vegetables.	Others	/
HY-P990225	Anti-Mouse IL-12 p40 Antibody (C17.8)	Anti-Mouse IL-12 p40 Antibody (C17.8) is a rat-derived anti-mouse IL-12 p40 IgG2a κ type antibody inhibitor. Anti-Mouse IL-12 p40 Antibody (C17.8) binds p40 subunit of IL-12. Anti-Mouse IL-12 p40 Antibody (C17.8) can be used for the researches of inflammation, immunology and metabolic disease, such as diabetes and arthritis. Species: Mouse	Interleukin Related Metabolic or Endocrine Disease Experimental Autoimmune Encephalomyelitis Experimental Autoimmune Encephalomyelitis	/
HY-N2024AS1	Maltose-13C12 monohydrate	Maltose monohydrate-¹³C₁₂ is the ¹³C labeled isotope of Maltose monohydrate. Maltose monohydrate is a disaccharide composed of two glucose molecules linked together. Maltose monohydrate is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose monohydrate is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose monohydrate can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.	Isotope-Labeled Compounds Glycosidase Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-W003601	2-Bromo-4-fluoropyridine	2-Bromo-4-fluoropyridine is a synthetic halogenated heterocyclic organic compound and a key intermediate in the pharmaceutical and agrochemical industries. 2-Bromo-4-fluoropyridine can be used to synthesize bioactive molecules through cross-coupling reactions, such as Suzuki coupling or Buchwald-Hartwig amination.	Biochemical Assay Reagents	/
HY-D2836	FITC-HA (MW 1000000)	FITC-HA (MW 1000000) is hyaluronic acid (HA) (HY-B0633A) labeled with FITC (HY-66019). FITC-HA retains the ability of HA to bind to receptors (such as CD44) and form extracellular matrices, while it can be detected by fluorescence microscopy or flow cytometry for tracing the localization, binding, internalization and metabolic pathways of HA in cells, tissues or living organisms (Ex/Em ≈ 490/520 nM).	Fluorescent Dye	/
HY-P990964	Efimosfermin alfa	Efimosfermin alfa is a genetically engineered FGF21 variant. Efimosfermin alfa exerts its function by activating the FGFR1c/β-Klotho complex. Efimosfermin alfa is applicable to researches on metabolic dysfunction-associated steatohepatitis, obesity and mild hypertriglyceridemia. Species: Human	FGFR Inflammation or Immune System Disease Obesity Hypertriglyceridemia	/
HY-77817	Pyrrole-2-carboxaldehyde	Pyrrole-2-carboxaldehyde (2-Formylpyrrole) is a heterocyclic organic compound that serves as a scaffold for the synthesis of various bioactive compounds.	Drug Intermediate	/
HY-134424	Propionyl coenzyme A lithium	Propionyl coenzyme A lithium, a coenzyme A derivative of propionic acid, is an important metabolic intermediate formed by the thioester bond between coenzyme A and propionic acid. The breakdown and production of Propionyl coenzyme A lithim is important for the metabolism of organisms.	Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-W099580	Hexadecane	Hexadecane (n-Hexadecane; Cetane) is a long-chain n-alkane, oil component, and model hydrophobic compound. Hexadecane acts as a substrate for microbial degradation.Hexadecane induces microbial biosurfactant and bioemulsifier synthesis.	Environmental Pollutants	/
HY-P10936A	AQP4 (201-220) TFA	AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. AQP4 (201-220) TFA can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica.	Aquaporin Neurological, Eye or Ear Disease Inflammation or Immune System Disease	/
HY-113114	Tetrahydrocortisone	Tetrahydrocortisone is a corticosteroid catalyzed from endogenous glucocorticoids by AKR1D1 (5_β-reductase). Its formation is mediated by AKR1D1 and regulated by the glucocorticoid receptor (GR). As one of the final products of glucocorticoid inactivation metabolism, Tetrahydrocortisone participates in the maintenance of glucocorticoid metabolic homeostasis in vivo. Tetrahydrocortisone can be used for mechanistic studies of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and also serves as a biomarker for in vivo AKR1D1 activity and glucocorticoid metabolic status.	Endogenous Metabolite Glucocorticoid Receptor Digestive System Disease Digestive System Inflammation Type 2 Diabetes	/
HY-D0168	Orcinol	Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases. Source: Aspergillus niger	Fluorescent Dye Free Radical Scavengers Tyrosinase p38 MAPK ERK Cancer Metabolic or Endocrine Disease	/
HY-125809	4-(1-Phenylethyl)resorcinol	4-(1-Phenylethyl)resorcinol is a skin lightening agent used in cosmetics. It works by inhibiting the production of melanin, the pigment that gives skin its color. This helps reduce the appearance of dark spots, hyperpigmentation and uneven skin tone. 4-(1-Phenylethyl)resorcinol is considered safe for cosmetic use and is approved for use in several countries.	Biochemical Assay Reagents	/
HY-P3267A	Apo-Bovine Transferrin	Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe²⁺ to Fe³⁺. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research.	Ferroportin Transferrin Receptor Neurological, Eye or Ear Disease	/
HY-128746	2,6-Diaminoheptanedioic acid	2,6-Diaminopimelic acid is a endogenous metabolite produced in bacteria and is a component of cell wall. 2,6-Diaminopimelic acid is essential for microbial metabolism and is a potential marker for quantification of microbial proteins .	Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-D1872	800CW NHS ester	800CW NHS ester is a near-infrared fluorescent dye active ester that can conjugate with amine-containing small molecules, antibodies, peptides, and other substances to form fluorescent conjugates. 800CW NHS ester exhibits high fluorescence quantum yield and low non-specific binding properties. 800CW NHS ester can be used in biomedical research such as microbial infection imaging, tumor imaging, and biochemical detection.	Fluorescent Dye	/
HY-125863	Glucose-6-phosphate dehydrogenase, Microorganism	Glucose-6-phosphate dehydrogenase, Microorganism (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase, Microorganism is a primary source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 systems, and others. Glucose-6-phosphate dehydrogenase, Microorganism is applicable in research related to diabetes, endothelial dysfunction, cancer, and cardiomyopathy.	Biochemical Assay Reagents Cancer Glucose Metabolism	/
HY-W011927	4,4'-Sulfonyldiphenol	4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an oally ative estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC₅₀ values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.	Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor Drug Derivative Metabolic or Endocrine Disease Breast Cancer Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Depression Pain Digestive System Inflammation Cardiovascular Disease	/
HY-P2542	GIP (3-42), human	GIP (3-42), human acts as a glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist, moderating the insulin secreting and metabolic actions of GIP in vivo.	Insulin Receptor Metabolic or Endocrine Disease	/
HY-113491	3-Phosphoglyceric acid	3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.	Endogenous Metabolite Glycolysis	/
HY-P705928	STUB1 Protein, Human (His)	STUB1 protein is an E3 ubiquitin protein ligase that cooperates with ATXN3 to regulate ubiquitin chain length on substrates and prevent chain extension. It ubiquitinates NOS1 through Hsp70/Hsp40 and regulates chaperone complexes (Hsp70, Hsc70, Hsp90). STUB1 Protein, Human (His) is the recombinant human-derived STUB1 protein, expressed by E. coli , with His tag. Species: Human; Source: E. coli		/
HY-P72086	AQP1 Protein, Human (GST)	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (GST) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-GST labeled tag. Species: Human; Source: E. coli		/
HY-P72085	AQP1 Protein, Human (His-SUMO)	The AQP1 protein forms water-specific channels that allow water to cross red blood cells and renal proximal tubule membranes. AQP1 Protein, Human (His-SUMO) is the recombinant human-derived AQP1 protein, expressed by E. coli , with N-6His, N-SUMO labeled tag. Species: Human; Source: E. coli*		/
HY-P75691	CSEN Protein, Human (His)	CSEN is a calcium-dependent transcriptional repressor that binds to the DRE elements of genes such as PDYN and FOS. Its affinity to DNA is affected by calcium. The binding force is reduced in the presence of calcium and enhanced when combined with magnesium. CSEN Protein, Human (His) is the recombinant human-derived CSEN protein, expressed by E. coli , with N-His labeled tag. Species: Human; Source: E. coli		/
HY-P82351	STUB1 Antibody (YA2096)	STUB1 Antibody (YA2096) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STUB1. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P81404	Aquaporin 1 Antibody (YA1149)	Aquaporin 1 Antibody (YA1149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 1. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P811615	KCNIP2 Antibody	KCNIP2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to KCNIP2. Host: Rabbit; Reactivity: Human, Mouse, Rat	Polyclonal Antibodies Primary Antibodies	/
HY-P811794	KCNIP1 Antibody (YA10265)	KCNIP1 Antibody (YA10265) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to KCNIP1. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P811794A	KCNIP1 Antibody (YA10265) (PBS only)	KCNIP1 Antibody (YA10265) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to KCNIP1. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P81404A	Aquaporin 1 Antibody (YA1149)(PBS only)	Aquaporin 1 Antibody (YA1149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 1. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P86699	Aquaporin 1 Antibody (YA6391)	Aquaporin 1 Antibody (YA6391) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 1. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P88844	SCHIP1 Antibody (YA8528)	SCHIP1 Antibody (YA8528) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SCHIP1. Host: Mouse; Reactivity: Human, Dog, Rat, Monkey, Mouse	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P88844A	SCHIP1 Antibody (YA8528)(PBS only)	SCHIP1 Antibody (YA8528) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SCHIP1. Host: Mouse; Reactivity: Human, Dog, Rat, Monkey, Mouse	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-K0355	Mouse CD3 Cell Depletion Magnetic Beads (Positive Selection)	MCE Mouse CD3 Cell Depletion Magnetic Beads (Positive Selection) are magnetic beads covalently coupled with anti-mouse CD3 antibodies, enabling the specific binding and magnetic removal of CD3+ cells from single-cell suspensions derived from mouse spleen and other tissues. This allows efficient enrichment of the non-CD3⁺ cell population.	Cell Biology Cell Isolation	/
HY-K0356	Human CD3 Cell Depletion Magnetic Beads (Positive Selection)	MCE Human CD3 Cell Depletion Magnetic Beads (Positive Selection) are magnetic beads covalently coupled with anti-human CD3 antibodies, enabling the specific binding and magnetic removal of CD3⁺ cells from single-cell suspensions derived from human peripheral blood mononuclear cells (PBMCs) or human peripheral blood leukocytes (WBCs). This allows efficient enrichment of the non-CD3⁺ cell population.	Cell Biology Cell Isolation	/
HY-K0357	Mouse Mature B Cell Negative Selection Kit	MCE Mouse Mature B Cell Negative Selection Kit enables the efficient isolation of mature B cells from single-cell suspensions prepared from mouse spleen, lymph nodes, or bone marrow. The principle involves using biotin-labeled monoclonal antibodies to label non-target cells (non-B cells), followed by the removal of these non-target cells through streptavidin-labeled magnetic beads, achieving the selective isolation of mouse mature B cells.	Cell Biology Cell Isolation	/
HY-K0358	Human CD66b⁺ Cell Positive Selection Kit	MCE Human CD66b⁺ Cell Positive Selection Kit is designed for the efficient isolation of CD66b⁺ cells from human peripheral blood single-cell suspensions. CD66b⁺ cells are first specifically labeled with the CD66b Capture Antibody and subsequently captured using Releasable Magnetic Beads. Following magnetic separation, the beads are detached from the cell surface using Magnetic Beads Release Buffer, resulting in highly purified CD66b⁺ cells free of residual magnetic bead labeling.	Cell Biology Cell Isolation	/
HY-K0360	Mouse CD4⁺ CD25⁺ Regulatory T Cell Positive Selection Kit	MCE Mouse CD4⁺ CD25⁺ Regulatory T Cell Positive Selection Kit is designed for the isolation of CD4⁺ CD25⁺ regulatory T cells (Tregs) from mouse splenic single-cell suspensions. The kit utilizes a two-step isolation strategy. First, CD4 Enrichment Beads are used to deplete non-target cells and enrich CD4⁺ T cells. Subsequently, CD25 Capture Antibody specifically binds to CD25⁺ cells, which are then captured by Releasable Magnetic Beads. Following isolation, the magnetic beads are gently detached from the cell surface using Magnetic Beads Release Buffer, yielding label-free CD4⁺ CD25⁺ regulatory T cells with no residual magnetic beads.	Cell Biology Cell Isolation	/
HY-K1043A	Polyamine Supplement (1000×)	MCE Polyamine Supplement (1000×) can be used as a component of the CEPT Cocktail in combination with Emricasan, Chroman 1, and trans-ISRIB to enhance the survival of pluripotent stem cells (PSCs) and promote single-cell clonal expansion. In addition, this supplement improves the viability of PSCs and their differentiated derivatives during cryopreservation, organoid culture, single-cell cloning, and genome editing, thereby enhancing the robustness and reproducibility of downstream applications.	Cell Biology Cell Culture CEPT cocktail	/
HY-K3030	Ham's F-12K (Kaighn's)	Ham’s F-12K Medium was originally designed for the culture of primary human hepatocytes and differentiated rat and chicken cells. It is particularly suitable for single-cell cloning of Chinese hamster ovary (CHO) cells under serum-free conditions. When supplemented with serum, it can also be used for the culture of various other mammalian cell types, including chondrocytes and rat prostate epithelial cells.	Cell Biology Cell Culture Basal Cell Culture Media	/
HY-K3038	Sodium Bicarbonate Solution (7.5%)	MCE Sodium Bicarbonate Solution (7.5%) is designed to adjust the bicarbonate buffering system of cell culture media. Under appropriate CO₂ culture conditions, sodium bicarbonate helps maintain physiological pH, neutralizes acidic metabolites produced by cellular metabolism, and provides a stable environment for cell growth. It also supplies bicarbonate ions required for certain cellular metabolic processes.	Cell Biology Cell Culture Cell Culture Supplements	/
HY-K3042	Ham's F-12 Medium (with Phenol Red and L-Alanyl-L-Glutamine)	Ham's F-12 Medium was developed by Ham in 1969 from Ham's F-10 Medium. It was originally designed for serum-free, single-cell plating of Chinese hamster ovary (CHO) cells.	Cell Biology Cell Culture Basal Cell Culture Media	/
HY-K3110	T-Cell Expansion Medium (Serum-Free)	MCE T-Cell Expansion Medium (Serum-Free) is a specialized culture medium formulated for the in vitro cultivation and robust expansion of human T lymphocytes without the need for serum.	Cell Biology Cell Culture Specialized Cell Culture Medium	/
HY-K6023	Cardiomyocyte Dissociation Solution	MCE Cardiomyocyte Dissociation Solution is specifically designed for the dissociation of cardiomyocytes following PSC differentiation and selection. It contains highly active collagenase, dispase, and neutral protease, which work synergistically with a low concentration of recombinant serine protease to efficiently and gently dissociate densely adherent cardiomyocytes into a single-cell suspension.	Cell Biology Cell Culture 3D Cell Culture Dissociation Reagents PSC Induction Product Series	/
HY-K6503	Human PSC Embryoid Body (EB) Induction Medium	MCE Human PSC Embryoid Body (EB) Induction Medium is specifically designed to support the efficient and reproducible formation of uniform embryoid bodies from pluripotent stem cells under suspension culture conditions. This optimized culture system integrates microenvironmental regulation with metabolic adaptation strategies, significantly improving the stability and reproducibility of EB formation.	Cell Biology 3D Cell Culture PSC Induction Product Series	/

Targets/Pathways

Keywords

Microbial Dark Matter: Progress, Challenges, And Opportunities

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