Ceftriaxone-d3 disodium
Based on 1 Customer Validation
Ceftriaxone-d3 (disodium) is the deuterium labeled Ceftriaxone. Ceftriaxone is a third-generation cephalosporin antibiotic with excellent activity against many gram-negative, and reasonable activity against most gram-positive microorganisms. Anti-inflammatory and antioxidant characteristics.
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- Pureté: 99.58%
- CAS No.: 1132650-38-4
- Formule: C18H14D3N8Na2O7S3
- Masse moléculaire:602.57
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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β-lactam |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1132650-38-4
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Unlabeled Cas 73384-59-5
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Appearance Solid
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Masse moléculaire 602.57
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Formule C18H14D3N8Na2O7S3
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Color White to off-white
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SMILES
O=C(C1=C(CSC(N(NC2=O)C)=NC2=O)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC([2H])([2H])[2H])=O)([H])N1C3=O)O[Na].[Na]
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Synonyms
Ro 13-9904-d3 disodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 31.25 mg/mL (51.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (560 KB)
- English - EN (560 KB)
- Français - FR (560 KB)
- Deutsch - DE (560 KB)
- Norwegian - NO (560 KB)
- Español - ES (560 KB)
- Swedish - SV (560 KB)
- Italian - IT (560 KB)
- Korean - KR (560 KB)
- Portuguese - PT (560 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Nahata MC, et al. Ceftriaxone: a third-generation cephalosporin. Drug Intell Clin Pharm. 1985;19(12):900-906. [Content Brief]
[3]. Hakimizadeh E, et al. Ceftriaxone improves hepatorenal damages in mice subjected to D-galactose-induced aging. Life Sci. 2020;258:118119. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6596 mL | 8.2978 mL | 16.5956 mL | 41.4890 mL |
| 5 mM | 0.3319 mL | 1.6596 mL | 3.3191 mL | 8.2978 mL | |
| 10 mM | 0.1660 mL | 0.8298 mL | 1.6596 mL | 4.1489 mL | |
| 15 mM | 0.1106 mL | 0.5532 mL | 1.1064 mL | 2.7659 mL | |
| 20 mM | 0.0830 mL | 0.4149 mL | 0.8298 mL | 2.0744 mL | |
| 25 mM | 0.0664 mL | 0.3319 mL | 0.6638 mL | 1.6596 mL | |
| 30 mM | 0.0553 mL | 0.2766 mL | 0.5532 mL | 1.3830 mL | |
| 40 mM | 0.0415 mL | 0.2074 mL | 0.4149 mL | 1.0372 mL | |
| 50 mM | 0.0332 mL | 0.1660 mL | 0.3319 mL | 0.8298 mL |
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