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  5. Paeonoside

Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality.

For research use only. We do not sell to patients.

Paeonoside Chemical Structure

Paeonoside Chemical Structure

CAS No. : 20309-70-0

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Description

Paeonoside is a bioactive compound identified in P. suffruticosa that promotes wound healing and migration in osteoblast differentiation. Paeonoside has also been reported to have some antidiabetic activity and may prevent sepsis-induced lethality[1].

In Vitro

Paeonoside (PASI) (0.1-100 μM, 24 h) has no cytotoxic effect on pro-osteoblasts of MC3T3-E1 cells[1].
Paeonoside (PASI) (1-30 μM, 24 h) can significantly restore wound areas and promote cell migration in a dose-dependent manner during the induction of preosteoblast of MC3T3-E1 cells differentiation using osteogenic supplement (OS) medium. In parallel, PASI promotes alkaline phosphatase (ALP) staining and its activity in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Pro-osteoblasts of MC3T3-E1 cells
Concentration: 1-10 μM
Incubation Time: 24 h
Result: Increased the expression of BMP2 and Wnt3a, stimulated Smad1/5/8 phosphorylation, GSK3β phosphorylation and β-linked protein expression as well as upregulated RUNX2 expression.
Molecular Weight

328.31

Formula

C15H20O8

CAS No.
SMILES

CC(C(C=CC(OC)=C1)=C1O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)=O

Initial Source
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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Paeonoside
Cat. No.:
HY-N2351
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