DM4-SMCC
Based on 1 Customer Validation
DM4-SMCC is a agent-linker conjugate for ADC with antitumor activity by using DM4 (an antitubulin agent), linked via the non-cleavable SMCC linker.
For research use only. We do not sell to patients.
- Purity: 96.86%
- CAS No.: 1228105-52-9
- Formula: C54H72ClN5O16S
- Molecular Weight:1114.69
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
More
Biological Activity
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Maytansinoids |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1228105-52-9
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Appearance Solid
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Molecular Weight 1114.69
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Formula C54H72ClN5O16S
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Color White to off-white
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SMILES
C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(C)(C)SC(C5)C(N(CC6CCC(C(ON7C(CCC7=O)=O)=O)CC6)C5=O)=O)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (112.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.8971 mL | 4.4856 mL | 8.9711 mL | 22.4278 mL |
| 5 mM | 0.1794 mL | 0.8971 mL | 1.7942 mL | 4.4856 mL | |
| 10 mM | 0.0897 mL | 0.4486 mL | 0.8971 mL | 2.2428 mL | |
| 15 mM | 0.0598 mL | 0.2990 mL | 0.5981 mL | 1.4952 mL | |
| 20 mM | 0.0449 mL | 0.2243 mL | 0.4486 mL | 1.1214 mL | |
| 25 mM | 0.0359 mL | 0.1794 mL | 0.3588 mL | 0.8971 mL | |
| 30 mM | 0.0299 mL | 0.1495 mL | 0.2990 mL | 0.7476 mL | |
| 40 mM | 0.0224 mL | 0.1121 mL | 0.2243 mL | 0.5607 mL | |
| 50 mM | 0.0179 mL | 0.0897 mL | 0.1794 mL | 0.4486 mL | |
| 60 mM | 0.0150 mL | 0.0748 mL | 0.1495 mL | 0.3738 mL | |
| 80 mM | 0.0112 mL | 0.0561 mL | 0.1121 mL | 0.2803 mL | |
| 100 mM | 0.0090 mL | 0.0449 mL | 0.0897 mL | 0.2243 mL |
DM4-SMCC Related Classifications
HY-126494 Related Classifications
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