ELMO1 - engulfment and cell motility 1 Gene

Also Known as CED12; CED-12; ELMO-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9844

About ELMO1

Cytogenetic location: 7p14.2-p14.1 Genomic coordinates (GRCh38): 7:36,852,906-37,449,326 (from NCBI)

This gene has 19 transcripts (splice variants), 239 orthologues and 5 paralogues. Broad expression in brain (RPKM 17.7), thyroid (RPKM 16.1) and 22 other tissues.

Summary

This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ELMO1 Products (5)

mRNA Protein Name
NM_001039459.3 NP_001034548.1 engulfment and cell motility protein 1 isoform 2
NM_001206480.2 NP_001193409.1 engulfment and cell motility protein 1 isoform 1
NM_001206482.2 NP_001193411.1 engulfment and cell motility protein 1 isoform 1
NM_014800.11 NP_055615.8 engulfment and cell motility protein 1 isoform 1
NM_130442.4 NP_569709.1 engulfment and cell motility protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
12029088 GOA
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
12134158 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12029088 GOA
Biological Process GO Annotation Evidence References Source
involved in Rac protein signal transduction IGI
IGI: Inferred from genetic interaction
11595183 GOA
involved in actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
11595183 GOA
involved in cell motility IGI
IGI: Inferred from genetic interaction
11595183 GOA
involved in phagocytosis, engulfment IGI
IGI: Inferred from genetic interaction
11595183 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11595183 GOA
part of guanyl-nucleotide exchange factor complex IDA
IDA: Inferred from direct assay
12134158 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11595183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELMO1 Protein Structure

DUF3361

DUF3361: Domain of unknown function (DUF3361) (114 - 281)

ELMO_CED12

ELMO_CED12: ELMO/CED-12 family (301 - 482)

  • 0
  • 200
  • 400
  • 600
  • 727 a.a.
Protein Preferred Names Protein Names

engulfment and cell motility protein 1

  • ced-12 homolog 1

ELMO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ELMO1 Q92556 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Intra
ELMO1 Q92556 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra
ELMO1 Q92556 HCK Homo sapiens P08631
Anti Bait CoIP
12029088
Intra
ELMO1 Q92556 HCK Homo sapiens P08631
Pull Down
12029088
Intra
ELMO1 Q92556 ANXA2 Homo sapiens P07355
Confocal
30853625
Intra
ELMO1 Q92556 ANXA2 Homo sapiens P07355
Anti Tag CoIP
30853625
Intra
ELMO1 Q92556 RHOG Homo sapiens P84095
Pull Down
12879077
Intra
ELMO1 Q92556 DOCK1 Homo sapiens Q14185
Anti Tag CoIP
33961781
Intra
ELMO1 Q92556 DOCK1 Homo sapiens Q14185
Anti Tag CoIP
30853625
Intra
ELMO1 Q92556 DOCK1 Homo sapiens Q14185
Anti Bait CoIP
18768751
Intra
ELMO1 Q92556 DOCK1 Homo sapiens Q14185
Anti Tag CoIP
28514442
Intra
ELMO1 Q92556 DOCK1 Homo sapiens Q14185
Pull Down
18768751
Intra
ELMO1 Q92556 ZNF398 Homo sapiens Q8TD17
Y2H Array
31515488
Intra
ELMO1 Q92556 ZNF398 Homo sapiens Q8TD17
Anti Tag CoIP
33961781
Intra
ELMO1 Q92556 ZNF398 Homo sapiens Q8TD17
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

ELMO1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82498 ELMO1 Antibody (YA2243) WB, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Diaphanospondylodysostosis

  • Vertebral Ossification, Defect In, With Nephrogenic Rests

  • DSD

  • Defect In Vertebral Ossification With Nephrogenic Rests
Immunodeficiency 40

  • Dock2 Deficiency

  • IMD40

  • Immunodeficiency, Type 40
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04311 ELMO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22485 Elmo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29008 Elmo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ELMO1 MGD MGI:2153044
Bos taurus ELMO1 VGNC VGNC:28438
Rattus norvegicus ELMO1 RGD RGD:1308182
Canis familiaris ELMO1 VGNC VGNC:40309
Macaca mulatta ELMO1 VGNC VGNC:72051
Felis catus ELMO1 VGNC VGNC:61815
Others ELMO1 NCBI