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Cat. No.: HY-143459

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Tyrosinase-IN-5

Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of tyrosinase with an IC₅₀ of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells.

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CAS No.: 2525175-90-8
Formule: C₁₈H₁₃N₃O₆
Masse moléculaire:367.31

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Tyrosinase-IN-5 Chemical Structure

CAS No.: 2525175-90-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	143.2 μM Compound: 16c	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability by MTT assay	[PMID: 32652434]
HFF	IC₅₀	194.1 μM Compound: 16c	Cytotoxicity against human HFF cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human HFF cells assessed as reduction in cell viability by MTT assay	[PMID: 32652434]

Chemical Information

CAS No. 2525175-90-8
Masse moléculaire 367.31
Formule C₁₈H₁₃N₃O₆
SMILES

O=C1C=C(OCC2=CN(CC3=CC(C(O)=CO3)=O)N=N2)C4=CC=CC=C4O1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ashooriha M, et al. Kojic acid-natural product conjugates as mushroom tyrosinase inhibitors. Eur J Med Chem. 2020;201:112480. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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