URAT1 inhibitor 7
Based on 1 Customer Validation
URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor, with an IC50 of 12 nM. URAT1 inhibitor 7 exhibits microsomal stability (HLM <13 µL/min/mg). URAT1 inhibitor 7 also inhibits CYP2C9, with an IC50 of 4.2 μM. URAT1 inhibitor 7 can be used for gout research.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 1632002-28-8
- Formula: C19H10ClFN4O3S
- Molecular Weight:428.82
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
12 nM
Compound: 10f
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Inhibition of human C-terminal eGFP-tagged URAT1 long isoform expressed in CHO cells assessed as decrease in [14C]-uric acid uptake preincubated for 15 mins followed by [14C]-uric acid addition and incubated in dark for 3 hrs by scintillation counting met
Inhibition of human C-terminal eGFP-tagged URAT1 long isoform expressed in CHO cells assessed as decrease in [14C]-uric acid uptake preincubated for 15 mins followed by [14C]-uric acid addition and incubated in dark for 3 hrs by scintillation counting met
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10.1039/C6MD00190D |
| HEK293 | IC50 |
>30 μM
Compound: 10f
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Inhibition of human NaV1.5 expressed in HEK293 cells by patch clamp method
Inhibition of human NaV1.5 expressed in HEK293 cells by patch clamp method
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10.1039/C6MD00190D |
Chemical Information
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CAS No. 1632002-28-8
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Appearance Solid
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Molecular Weight 428.82
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Formula C19H10ClFN4O3S
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Color White to off-white
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SMILES
N#CC1=CC=C(C=C1Cl)OC2=CC=C(S(=O)(NC3=NC=C(C=C3)F)=O)C=C2C#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (58.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3320 mL | 11.6599 mL | 23.3198 mL | 58.2995 mL |
| 5 mM | 0.4664 mL | 2.3320 mL | 4.6640 mL | 11.6599 mL | |
| 10 mM | 0.2332 mL | 1.1660 mL | 2.3320 mL | 5.8300 mL | |
| 15 mM | 0.1555 mL | 0.7773 mL | 1.5547 mL | 3.8866 mL | |
| 20 mM | 0.1166 mL | 0.5830 mL | 1.1660 mL | 2.9150 mL | |
| 25 mM | 0.0933 mL | 0.4664 mL | 0.9328 mL | 2.3320 mL | |
| 30 mM | 0.0777 mL | 0.3887 mL | 0.7773 mL | 1.9433 mL | |
| 40 mM | 0.0583 mL | 0.2915 mL | 0.5830 mL | 1.4575 mL | |
| 50 mM | 0.0466 mL | 0.2332 mL | 0.4664 mL | 1.1660 mL |
URAT1 inhibitor 7 Related Classifications
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