URAT1 inhibitor 7

Cat. No.: HY-153970 Purity: 98.01%: Data Sheet
COA

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Handling Instructions
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URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor, with an IC₅₀ of 12 nM. URAT1 inhibitor 7 exhibits microsomal stability (HLM <13 µL/min/mg). URAT1 inhibitor 7 also inhibits CYP2C9, with an IC₅₀ of 4.2 μM. URAT1 inhibitor 7 can be used for gout research.

For research use only. We do not sell to patients.

URAT1 inhibitor 7 Chemical Structure

CAS No. : 1632002-28-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	12 nM Compound: 10f	Inhibition of human C-terminal eGFP-tagged URAT1 long isoform expressed in CHO cells assessed as decrease in [14C]-uric acid uptake preincubated for 15 mins followed by [14C]-uric acid addition and incubated in dark for 3 hrs by scintillation counting met Inhibition of human C-terminal eGFP-tagged URAT1 long isoform expressed in CHO cells assessed as decrease in [14C]-uric acid uptake preincubated for 15 mins followed by [14C]-uric acid addition and incubated in dark for 3 hrs by scintillation counting met	10.1039/C6MD00190D
HEK293	IC₅₀	>30 μM Compound: 10f	Inhibition of human NaV1.5 expressed in HEK293 cells by patch clamp method Inhibition of human NaV1.5 expressed in HEK293 cells by patch clamp method	10.1039/C6MD00190D

Molecular Weight

428.82

Formula

C₁₉H₁₀ClFN₄O₃S

CAS No.

1632002-28-8

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=C(C=C1Cl)OC2=CC=C(S(=O)(NC3=NC=C(C=C3)F)=O)C=C2C#N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (58.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3320 mL	11.6599 mL	23.3198 mL
5 mM	0.4664 mL	2.3320 mL	4.6640 mL
10 mM	0.2332 mL	1.1660 mL	2.3320 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.01%

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Data Sheet (268 KB) SDS (252 KB)

COA (247 KB) HNMR (135 KB) RP-HPLC (211 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Storer R I, et al. The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. MedChemComm, 2016:10.1039.C6MD00190D.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3320 mL	11.6599 mL	23.3198 mL	58.2995 mL
	5 mM	0.4664 mL	2.3320 mL	4.6640 mL	11.6599 mL
	10 mM	0.2332 mL	1.1660 mL	2.3320 mL	5.8300 mL
	15 mM	0.1555 mL	0.7773 mL	1.5547 mL	3.8866 mL
	20 mM	0.1166 mL	0.5830 mL	1.1660 mL	2.9150 mL
	25 mM	0.0933 mL	0.4664 mL	0.9328 mL	2.3320 mL
	30 mM	0.0777 mL	0.3887 mL	0.7773 mL	1.9433 mL
	40 mM	0.0583 mL	0.2915 mL	0.5830 mL	1.4575 mL
	50 mM	0.0466 mL	0.2332 mL	0.4664 mL	1.1660 mL