POP7 - POP7 homolog, ribonuclease P/MRP subunit Gene

Also Known as RPP2; RPP20; 0610037N12Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10248

About POP7

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,706,121-100,707,486 (from NCBI)

This gene has 2 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in prostate (RPKM 11.3), brain (RPKM 11.1) and 25 other tissues.

Summary

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]

POP7 Products (1)

mRNA	Protein	Name
NM_005837.3	NP_005828.2	ribonuclease P protein subunit p20

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14715275	GOA
enables ribonuclease P RNA binding	IDA IDA: Inferred from direct assay	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: Inferred from direct assay	30454648	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in tRNA 5'-leader removal	IDA IDA: Inferred from direct assay	16723659	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of multimeric ribonuclease P complex	IDA IDA: Inferred from direct assay	16723659	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	20215441	GOA
part of ribonuclease MRP complex	IDA IDA: Inferred from direct assay	16723659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POP7 Protein Structure

Rpp20

0
100
140 a.a.

Protein Preferred Names	Protein Names
ribonuclease P protein subunit p20	POP7 (processing of precursor, S. cerevisiae) homolog

POP7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POP7	O75817	RPP25L	Homo sapiens	Q8N5L8	Y2H Array	31515488
Intra	POP7	O75817	RPP25L	Homo sapiens	Q8N5L8	Validated Y2H	25416956
Intra	POP7	O75817	RPP25L	Homo sapiens	Q8N5L8	Anti Tag CoIP	33961781
Intra	POP7	O75817	RPP25L	Homo sapiens	Q8N5L8	Validated Y2H	32296183
Intra	POP7	O75817	RPP25L	Homo sapiens	Q8N5L8	Y2H Array	25416956
Intra	POP7	O75817	RPP25L	Homo sapiens	Q8N5L8	Y2H Array	32296183
Intra	POP7	O75817	RPP25L	Homo sapiens	Q8N5L8	Y2H Prey Pooling	32296183
Intra	POP7	O75817	LAGE3	Homo sapiens	Q14657	Validated Y2H	32296183
Intra	POP7	O75817	C9orf72	Homo sapiens	Q96LT7	Validated Y2H	32296183
Intra	POP7	O75817	RPP25	Homo sapiens	Q9BUL9	Validated Y2H	32296183
Intra	POP7	O75817	RPP25	Homo sapiens	Q9BUL9	Anti Tag CoIP	33961781
Intra	POP7	O75817	RPP25	Homo sapiens	Q9BUL9	Pull Down	15096576
Intra	POP7	O75817	RPP25	Homo sapiens	Q9BUL9	Y2H Array	32296183
Intra	POP7	O75817	RPP25	Homo sapiens	Q9BUL9	Y2H Prey Pooling	32296183
Intra	POP7	O75817	SMN1	Homo sapiens	Q16637	IF	14715275
Intra	POP7	O75817	SMN1	Homo sapiens	Q16637	Pull Down	14715275

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Anauxetic Dysplasia 2	ANXD2
Loiasis	Loa Loa Filariasis Mansonelliasis African Eye Worm Mansonella Perstans Infections Mansonellosis Eye Worm Disease Of Africa Loa Loa Infestation African Eyeworm Disease Calabar Swelling
Anauxetic Dysplasia 1	Anauxetic Dysplasia Spondylometaepiphyseal Dysplasia, Menger Type Spondylometaepiphyseal Dysplasia, Anauxetic Type Spondyloepimetaphyseal Dysplasia, Anauxetic Type ANXD1 Anxd Spondylometaepiphyseal Dysplasia Anauxetic Type Spondylometaepiphyseal Dysplasia Menger Type Ad Spondyloepimetaphyseal Dysplasia, Menger Type Dysplasia, Anauxetic, Type 1
Peroxisome Biogenesis Disorder 1b	Peroxisome Biogenesis Disorder Infantile Refsum Disease Infantile Phytanic Acid Storage Disease PBD1B Refsum Disease, Infantile Adrenoleukodystrophy, Autosomal Neonatal Ird Mild Pbd-Zsd Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Pbd-Zsd Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Autosomal Neonatal Adrenoleukodystrophy Refsum Disease Infantile Peroxisome Biogenesis Disorders Peroxisome Biogenesis Disorder, Type 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10878	POP7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POP7	VGNC	VGNC:33166
Felis catus	POP7	VGNC	VGNC:64299
Macaca mulatta	POP7	VGNC	VGNC:76079
Rattus norvegicus	POP7	RGD	RGD:1306413
Mus musculus	POP7	MGD	MGI:1921347
Canis familiaris	POP7	VGNC	VGNC:44818
Others	POP7	NCBI