Cpe - carboxypeptidase E Gene

Also Known as CPH; fat; Cph1; Cph-1; NF-alpha1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12876

Summary

This gene encodes Carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the "fat mouse." Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide Hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. [provided by RefSeq, Jan 2016]

Cpe Products (1)

mRNA Protein Name
NM_013494.4 NP_038522.2 carboxypeptidase E preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables carboxypeptidase activity IMP
IMP: Inferred from mutant phenotype
7663508 MGI
enables metallocarboxypeptidase activity IMP
IMP: Inferred from mutant phenotype
9348219 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16219686 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within insulin processing IMP
IMP: Inferred from mutant phenotype
7663508 MGI
involved in insulin processing IMP
IMP: Inferred from mutant phenotype
9348219 MGI
acts upstream of or within peptide hormone secretion IMP
IMP: Inferred from mutant phenotype
16219686 MGI
acts upstream of or within protein localization to secretory granule IMP
IMP: Inferred from mutant phenotype
16219686 MGI
Cellular Component GO Annotation Evidence References Source
is active in secretory granule IDA
IDA: Inferred from direct assay
9348219 MGI
located in secretory granule membrane IDA
IDA: Inferred from direct assay
16219686 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

carboxypeptidase E

  • carboxypeptidase H

  • enkephalin convertase

  • prohormone-processing carboxypeptidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-121528 Nilestriol 98.93% Unkown
HY-175469 VNT-101 Inhibitor 99.51% Unkown
HY-132169 HCoV-229E-IN-1 Inhibitor 99.16% Unkown
HY-12349 H1PVAT Inhibitor 96.40% Unkown
HY-P11455A Lipopeptide CPE4 TFA 98.69% Unkown
HY-106508 Fendosal Inhibitor 99.82% Unkown
HY-124938 ABC-1 / Unkown
HY-180578 MWAC-3429 Inhibitor / Unkown
HY-182731 Brain CPE / Unkown
HY-N18293 Makisterone A 2-acetate Control / Unkown
HY-P11455 Lipopeptide CPE4 / Unkown
HY-P11785 Cpe30 MT2 Ligand / Unkown
HY-RS03090 CPE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174385 SARS-CoV-2-IN-114 Inhibitor / Unkown
HY-180525 PB2-IN-2 Inhibitor / Unkown
HY-RS17120 Cpe Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23565 Cpe Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cpe NCBI NCBI:1363