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UVRAG - UV radiation resistance associated Gene

Also Known as p63; DHTX; VPS38

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7405

About UVRAG

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:75,815,210-76,144,232 (from NCBI)

This gene has 9 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in fat (RPKM 5.6), lymph node (RPKM 3.6) and 24 other tissues.

Summary

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting Autophagy and suppressing the proliferation and tumorigenicity of human colon Cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon Cancer. [provided by RefSeq, Jul 2008]

UVRAG Products (5)

mRNA	Protein	Name
NM_001386671.1	NP_001373600.1	UV radiation resistance-associated gene protein isoform 1
NM_001386672.1	NP_001373601.1	UV radiation resistance-associated gene protein isoform 3
NM_001386673.1	NP_001373602.1	UV radiation resistance-associated gene protein isoform 4
NM_001386674.1	NP_001373603.1	UV radiation resistance-associated gene protein isoform 5
NM_003369.4	NP_003360.2	UV radiation resistance-associated gene protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17891140	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA repair	IMP IMP: Inferred from mutant phenotype	22542840	GOA
involved in autophagosome maturation	IDA IDA: Inferred from direct assay	28306502	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	24056303	GOA
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	22542840	GOA
involved in double-strand break repair via classical nonhomologous end joining	IDA IDA: Inferred from direct assay	22542840	GOA
involved in maintenance of Golgi location	IMP IMP: Inferred from mutant phenotype	24056303	GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process	IDA IDA: Inferred from direct assay	8999962	GOA
involved in receptor catabolic process	IMP IMP: Inferred from mutant phenotype	20643123	GOA
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	16799551	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	20643123	GOA
involved in regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	22542840	GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	24056303	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of DNA-dependent protein kinase complex	IDA IDA: Inferred from direct assay	22542840	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	28306502	GOA
located in centrosome	IDA IDA: Inferred from direct assay	22542840	GOA
located in early endosome	IDA IDA: Inferred from direct assay	19270696	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24056303	GOA
located in late endosome	IDA IDA: Inferred from direct assay	19270696	GOA
located in lysosome	IDA IDA: Inferred from direct assay	19270696	GOA
located in midbody	IDA IDA: Inferred from direct assay	20643123	GOA
part of phosphatidylinositol 3-kinase complex, class III	IPI IPI: Inferred from physical interaction	25490155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UVRAG Protein Structure

Atg14

0
200
400
600
699 a.a.

Protein Preferred Names	Protein Names
UV radiation resistance-associated gene protein	beclin 1 binding protein

UVRAG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UVRAG	Q9P2Y5	PIK3C3	Homo sapiens	Q8NEB9	Anti Bait CoIP	22493499
Intra	UVRAG	Q9P2Y5	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	24056303
Intra	UVRAG	Q9P2Y5	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	20562859
Intra	UVRAG	Q9P2Y5	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	34386498
Intra	UVRAG	Q9P2Y5	PIK3C3	Homo sapiens	Q8NEB9	Anti Bait CoIP	24056303
Intra	UVRAG	Q9P2Y5	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	22493499
Intra	UVRAG	Q9P2Y5	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	24785657
Intra	UVRAG	Q9P2Y5	PIK3C3	Homo sapiens	Q8NEB9	Pull Down	25490155
Intra	UVRAG	Q9P2Y5	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	24849286
Intra	UVRAG	Q9P2Y5	VPS33A	Homo sapiens	Q96AX1	Anti Tag CoIP	20562859
Cross	UVRAG	Q9P2Y5	ap3a_sars2	SARS-CoV-2	P0DTC3	Anti Bait CoIP	34386498
Cross	UVRAG	Q9P2Y5	ap3a_sars2	SARS-CoV-2	P0DTC3	Confocal	34386498
Cross	UVRAG	Q9P2Y5	ap3a_sars2	SARS-CoV-2	P0DTC3	Anti Tag CoIP	34386498
Intra	UVRAG	Q9P2Y5	SH3GLB1	Homo sapiens	Q9Y371	Anti Tag CoIP	24056303
Intra	UVRAG	Q9P2Y5	SH3GLB1	Homo sapiens	Q9Y371	Anti Bait CoIP	24056303
Intra	UVRAG	Q9P2Y5	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	35271311
Intra	UVRAG	Q9P2Y5	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	34386498
Intra	UVRAG	Q9P2Y5	RUBCN	Homo sapiens	Q92622	Pull Down	21062745
Intra	UVRAG	Q9P2Y5	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	20562859
Intra	UVRAG	Q9P2Y5	BAX	Homo sapiens	Q07812	Anti Bait CoIP	21597469
Intra	UVRAG	Q9P2Y5	BAX	Homo sapiens	Q07812	Anti Tag CoIP	21597469
Intra	UVRAG	Q9P2Y5	RINT1	Homo sapiens	Q6NUQ1	Anti Tag CoIP	24056303
Intra	UVRAG	Q9P2Y5	RINT1	Homo sapiens	Q6NUQ1	Anti Bait CoIP	24056303
Cross	UVRAG	Q9P2Y5	Slamf1	Mus musculus	Q9QUM4	Anti Bait CoIP	22493499
Cross	UVRAG	Q9P2Y5	Slamf1	Mus musculus	Q9QUM4	Anti Tag CoIP	22493499
Intra	UVRAG	Q9P2Y5	BECN1	Homo sapiens	Q14457	Anti Tag CoIP	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cholecystolithiasis
Cornea Cancer	Malignant Neoplasm Of Cornea Neoplasm Of Cornea Corneal Tumor Malignant Corneal Tumor Malignant Tumor Of Cornea Primary Malignant Neoplasm Of Cornea
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156237	Beclin1-ATG14L interaction inhibitor 1	Inhibitor	99.88%	Unkown
HY-152100	CUR5g	Inhibitor	98.69%	Unkown
HY-183987	ZINC000002107582		/	Unkown
HY-RS15588	UVRAG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UVRAG	VGNC	VGNC:78751
Felis catus	UVRAG	VGNC	VGNC:66909
Rattus norvegicus	UVRAG	RGD	RGD:1589754
Mus musculus	UVRAG	MGD	MGI:1925860
Bos taurus	UVRAG	VGNC	VGNC:36751
Canis familiaris	UVRAG	VGNC	VGNC:48218
Others	UVRAG	NCBI