SOCS2 - suppressor of cytokine signaling 2 Gene

Also Known as CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8835

About SOCS2

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,569,969-93,626,236 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 13.5), prostate (RPKM 10.5) and 22 other tissues.

Summary

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by Cytokine Receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

SOCS2 Products (6)

mRNA Protein Name
NM_001270467.2 NP_001257396.1 suppressor of cytokine signaling 2
NM_001270468.2 NP_001257397.1 suppressor of cytokine signaling 2
NM_001270469.2 NP_001257398.1 suppressor of cytokine signaling 2
NM_001270470.1 NP_001257399.1 suppressor of cytokine signaling 2
NM_001270471.2 NP_001257400.1 suppressor of cytokine signaling 2
NM_003877.5 NP_003868.1 suppressor of cytokine signaling 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables insulin-like growth factor receptor binding IPI
IPI: Inferred from physical interaction
9727029 GOA
enables phosphorylation-dependent protein binding IDA
IDA: Inferred from direct assay
11781573 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11781573 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
11781573 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hormone stimulus IDA
IDA: Inferred from direct assay
12552091 GOA
involved in growth hormone receptor signaling pathway IDA
IDA: Inferred from direct assay
12552091 GOA
involved in negative regulation of growth hormone receptor signaling pathway IDA
IDA: Inferred from direct assay
21980433 GOA
involved in negative regulation of signal transduction IDA
IDA: Inferred from direct assay
11781573 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
11781573 GOA
involved in response to estradiol IDA
IDA: Inferred from direct assay
12552091 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul5-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
21980433 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
9727029 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOCS2 Protein Structure

SH2

SH2: SH2 domain (48 - 129)

SOCS_box

SOCS_box: SOCS box (161 - 195)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

suppressor of cytokine signaling 2

  • CIS-2

SOCS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SOCS2 O14508 CUL5 Homo sapiens Q93034
Lumier
29997244
Intra
SOCS2 O14508 CUL5 Homo sapiens Q93034
Pull Down
30833792
Intra
SOCS2 O14508 CUL5 Homo sapiens Q93034
Anti Tag CoIP
33961781
Intra
SOCS2 O14508 CUL5 Homo sapiens Q93034
BRET
29997244
Intra
SOCS2 O14508 CUL5 Homo sapiens Q93034
Anti Tag CoIP
28514442
Intra
SOCS2 O14508 CUL5 Homo sapiens Q93034
Lumier
32814053
Intra
SOCS2 O14508 KIT Homo sapiens P10721
FPS
24728074
Intra
SOCS2 O14508 ELOC Homo sapiens Q15369
Anti Tag CoIP
19159283
Intra
SOCS2 O14508 YES1 Homo sapiens P07947
Validated Y2H
32296183
Intra
SOCS2 O14508 EPOR Homo sapiens P19235
MAPPIT
11781573
Intra
SOCS2 O14508 STK16 Homo sapiens O75716
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SOCS2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80328 SOCS2 Antibody (YA072) WB, ICC/IF, IP, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Placental Insufficiency

  • Uteroplacental Vascular Insufficiency
Essential Thrombocythemia

  • Essential Thrombocytosis

  • Familial Thrombocytosis

  • Hemorrhagic Thrombocythemia

  • Hereditary Thrombocythemia

  • Primary Thrombocytosis

  • Idiopathic Thrombocythemia

  • Primary Thrombocythemia

  • Thrombocythemia, Essential

  • Essential Thrombocythaemia

  • Et

  • Familial Thrombocythemia

  • Thrombocythemia Essential
Polycythemia Vera

  • PV

  • Polycythemia Rubra Vera

  • Prv

  • Osler-Vaquez Disease

  • Chronic Erythremia

  • Polycythaemia Rubra Vera

  • Primary Polycythemia

  • Vaquez Disease

  • Polycythemia Vera, Somatic

  • Osler-Vaquez Syndrome

  • Proliferative Polycythaemia

  • Polycythemia Ruba Vera

  • Acquired Primary Erythrocytosis

  • Heilmeyer-Schoner Disease

  • Vaquez Osler Disease

  • Primary Polycythaemia
Glycine N-Methyltransferase Deficiency

  • GNMT DEFICIENCY

  • Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency

  • Hypermethioninemia Due To Gnmt Deficiency

  • Hypermethioninemia

  • Hepatic Methionine Adenosyltransferase Deficiency
Leukemia, Chronic Myeloid

  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156395 MN551 Inducer 98.01% Unkown
HY-156373 MN714 Inhibitor 99.12% Unkown
HY-173364 EB-TCIP Inducer 99.58% Unkown
HY-RS13553 SOCS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18546 Socs2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25028 Socs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SOCS2 MGD MGI:1201787
Felis catus SOCS2 VGNC VGNC:97640
Canis familiaris SOCS2 VGNC VGNC:46649
Rattus norvegicus SOCS2 RGD RGD:69273
Bos taurus SOCS2 VGNC VGNC:35120
Others SOCS2 NCBI