Mitomycin Z
Mitomycin Z (9a-O-Demethylmitomycin G) is a member of the mitomycin family with an antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 74148-47-3
- Formula: C14H15N3O3
- Molecular Weight:273.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF S-180 | ED50 |
82 μg/mL
Compound: 51
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Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed as tumor volume after 7 days
Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed as tumor volume after 7 days
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[PMID: 19540628] |
Chemical Information
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CAS No. 74148-47-3
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Molecular Weight 273.29
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Formula C14H15N3O3
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SMILES
O[C@]12N(C[C@@]3([H])[C@]2([H])N3C)C4=C(C(C(N)=C(C4=O)C)=O)C1=C
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Synonyms
9a-O-Demethylmitomycin G
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Structure Classification
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Initial Source
mitomycins
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mitomycin Z Related Classifications
HY-169500 Related Classifications
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