Prenylterphenyllin
Prenylterphenyllin (Compound 1) is an antibacterial agent. Prenylterphenyllin can be isolated from marine-derived fungus Aspergillus candidus IF10. Prenylterphenyllin has cytotoxic activity against KB3-1 cells with an IC50 of 8.5 mg/mL. Prenylterphenyllin also has antibacterial activities against Xanthomonas oryzae and Erwinia amylovora with MICs of both 20 μg/mL.
For research use only. We do not sell to patients.
- CAS No.: 959124-85-7
- Formula: C25H26O5
- Molecular Weight:406.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.62 μM
Compound: 8
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Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
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[PMID: 21486068] |
| HepG2 | IC50 |
2.74 μM
Compound: 5
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Cytotoxicity against human HepG2 cells by SRB assay
Cytotoxicity against human HepG2 cells by SRB assay
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[PMID: 29407953] |
| HL-60 | IC50 |
2.75 μM
Compound: 8
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Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
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[PMID: 21486068] |
| P388 | IC50 |
1.99 μM
Compound: 8
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Cytotoxicity against mouse P388 cells by MTT assay
Cytotoxicity against mouse P388 cells by MTT assay
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[PMID: 21486068] |
Chemical Information
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CAS No. 959124-85-7
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Molecular Weight 406.47
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Formula C25H26O5
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SMILES
OC1=CC=C(C2=CC(OC)=C(C3=CC=C(C(C/C=C(C)\C)=C3)O)C(O)=C2OC)C=C1
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Structure Classification
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Initial Source
Aspergillus candidus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
[1]. Wei H, Inada H, et al. Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived Fungus Aspergillus candidus IF10. J Antibiot (Tokyo). 2007 Sep;60(9):586-90. [Content Brief]
[2]. El-Hawary SS, et al. Natural product diversity from the endophytic fungi of the genus Aspergillus. RSC Adv. 2020 Jun 9;10(37):22058-22079. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Prenylterphenyllin Related Classifications
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