(Rac)-MTK458
(Rac)-MTK458 (compound 16) is an activator of mitophagy. EP-0035985 is the isomer of EP-0035985.
For research use only. We do not sell to patients.
- CAS No.: 2499962-44-4
- Formula: C17H15F3N4
- Molecular Weight:332.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
440 nM
Compound: Mitokinin-EP-0035985
|
Induction of mitophagy in human HeLa cells
Induction of mitophagy in human HeLa cells
|
[PMID: 34458736] |
Chemical Information
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CAS No. 2499962-44-4
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Molecular Weight 332.32
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Formula C17H15F3N4
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SMILES
FC(F)(C1=CC2=C(NC3C4=C(CCC3)C=CC=C4)N=CN=C2N1)F
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Synonyms
(Rac)-EP-0035985
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mitophagy is a selective form of autophagy that eliminates damaged or dysfunctional mitochondria and thereby preserves mitochondrial quality control, cellular homeostasis, and neuronal survival.
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Mitophagy becomes an innate immune checkpoint when selective autophagic removal of damaged mitochondria regulates the availability of mitochondrial danger signals that activate innate immune pathways.
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)