TBZ-1
TBZ-1 is a cell-permeable fluorescent probe that monitors immunoproteasome (Proteasome) (iCP) activity in cells. TBZ-1 is useful for lung cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2357123-44-3
- Formula: C68H90N14O15S
- Molecular Weight:1375.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
TBZ-1 reports β5i/iCP activity in IFN-γ-treated A549 cells, and this activity is attenuated by iCP inhibition[1].
TBZ-1 is approximately 35% cell-permeable in the live-cell assay[2].
TBZ-1 (31 μM) produces intracellular Rh110 fluorescence in IFN-γ-treated A549 cells that increases over 0-30 min and is reduced by iCP inhibition[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2357123-44-3
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Molecular Weight 1375.59
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Formula C68H90N14O15S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Muli CS, et al. Immunoproteasome as a Target for Prodrugs. J Med Chem. 2025 Mar 27;68(6):6507-6517. [Content Brief]
[2]. Zerfas BL, et al. Monitoring the Immunoproteasome in Live Cells Using an Activity-Based Peptide-Peptoid Hybrid Probe. Journal of the American Chemical Society. 2019 Apr 03;141(13):5252-5260. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TBZ-1 Related Classifications
HY-P11595 Related Classifications
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